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1. Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity

Author: Mark K. Bakker, Jos P. Kanning, Gad Abraham, Amy E. Martinsen, Bendik S. Winsvold, John-Anker Zwart, Romain Bourcier, Tomonobu Sawada, Masaru Koido, Yoichiro Kamatani, Sandrine Morel, Philippe Amouyel, Stéphanie Debette, Philippe Bijlenga, Takiy Berrandou, Santhi K. Ganesh, Nabila Bouatia-Naji, Gregory Jones, Matthew Bown, Gabriel J.E. Rinkel, Jan H. Veldink, Ynte M. Ruigrok, Anne Hege Aamodt, Anne Heidi Skogholt, Ben M Brumpton, Cristen J Willer, Else C Sandset, Espen S Kristoffersen, Hanne Ellekjær, Ingrid Heuch, Jonas B Nielsen, Knut Hagen, Kristian Hveem, Lars G Fritsche, Laurent F Thomas, Linda M Pedersen, Maiken E Gabrielsen, Oddgeir L Holmen, Sigrid Børte, Wei Zhou, Shérine Abboud, Massimo Pandolfo, Vincent Thijs, Didier Leys, Marie Bodenant, Fabien Louillet, Emmanuel Touzé, Jean-Louis Mas, Yves Samson, Sara Leder, Anne Léger, Sandrine Deltour, Sophie Crozier, Isabelle Méresse, Sandrine Canaple, Olivier Godefroy, Maurice Giroud, Yannick Béjot, Pierre Decavel, Elizabeth Medeiros, Paola Montiel, Thierry Moulin, Fabrice Vuillier, Jean Dallongeville, Antti J Metso, Tiina Metso, Turgut Tatlisumak, Caspar Grond-Ginsbach, Christoph Lichy, Manja Kloss, Inge Werner, Marie-Luise Arnold, Michael Dos Santos, Armin Grau, Martin Dichgans, Constanze Thomas-Feles, Ralf Weber, Tobias Brandt, Alessandro Pezzini, Valeria De Giuli, Filomena Caria, Loris Poli, Alessandro Padovani, Anna Bersano, Silvia Lanfranconi, Simone Beretta, Carlo Ferrarese, Giacomo Giacolone, Stefano Paolucci, Philippe Lyrer, Stefan Engelter, Felix Fluri, Florian Hatz, Dominique Gisler, Leo Bonati, Henrik Gensicke, Margareth Amort, Hugh Markus, Jennifer Majersik, Bradford Worrall, Andrew Southerland, John Cole, Steven Kittner, Evangelos Evangelou, Helen R Warren, He Gao, Georgios Ntritsos, Niki Dimou, Tonu Esko, Reedik Mägi, Lili Milani, Peter Almgren, Thibaud Boutin, Jun Ding, Franco Giulianini, Elizabeth G Holliday, Anne U Jackson, Ruifang Li-Gao, Wei-Yu Lin, Jian’an Luan, Massimo Mangino, Christopher Oldmeadow, Bram Peter Prins, Yong Qian, Muralidharan Sargurupremraj, Nabi Shah, Praveen Surendran, Sébastien Thériault, Niek Verweij, Sara M Willems, Jing-Hua Zhao, John Connell, Renée de Mutsert, Alex SF Doney, Martin Farrall, Cristina Menni, Andrew D Morris, Raymond Noordam, Guillaume Paré, Neil R Poulter, Denis C Shields, Alice Stanton, Simon Thom, Gonçalo Abecasis, Najaf Amin, Dan E Arking, Kristin L Ayers, Caterina M Barbieri, Chiara Batini, Joshua C Bis, Tineka Blake, Murielle Bochud, Michael Boehnke, Eric Boerwinkle, Dorret I Boomsma, Erwin P Bottinger, Peter S Braund, Marco Brumat, Archie Campbell, Harry Campbell, Aravinda Chakravarti, John C Chambers, Ganesh Chauhan, Marina Ciullo, Massimiliano Cocca, Francis Collins, Heather J Cordell, Gail Davies, Martin H de Borst, Eco J de Geus, Ian J Deary, Joris Deelen, Fabiola Del Greco M, Cumhur Yusuf Demirkale, Marcus Dörr, Georg B Ehret, Roberto Elosua, Stefan Enroth, A Mesut Erzurumluoglu, Teresa Ferreira, Mattias Frånberg, Oscar H Franco, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Christian Gieger, Giorgia Girotto, Anuj Goel, Alan J Gow, Vilmundur Gudnason, Xiuqing Guo, Ulf Gyllensten, Anders Hamsten, Tamara B Harris, Sarah E Harris, Catharina A Hartman, Aki S Havulinna, Andrew A Hicks, Edith Hofer, Albert Hofman, Jouke-Jan Hottenga, Jennifer E Huffman, Shih-Jen Hwang, Erik Ingelsson, Alan James, Rick Jansen, Marjo-Riitta Jarvelin, Roby Joehanes, Åsa Johansson, Andrew D Johnson, Peter K Joshi, Pekka Jousilahti, J Wouter Jukema, Antti Jula, Mika Kähönen, Sekar Kathiresan, Bernard D Keavney, Kay-Tee Khaw, Paul Knekt, Joanne Knight, Ivana Kolcic, Jaspal S Kooner, Seppo Koskinen, Kati Kristiansson, Zoltan Kutalik, Maris Laan, Marty Larson, Lenore J Launer, Benjamin Lehne, Terho Lehtimäki, David CM Liewald, Li Lin, Lars Lind, Cecilia M Lindgren, YongMei Liu, Ruth JF Loos, Lorna M Lopez, Yingchang Lu, Leo-Pekka Lyytikäinen, Anubha Mahajan, Chrysovalanto Mamasoula, Jaume Marrugat, Jonathan Marten, Yuri Milaneschi, Anna Morgan, Andrew P Morris, Alanna C Morrison, Peter J Munson, Mike A Nalls, Priyanka Nandakumar, Christopher P Nelson, Teemu Niiranen, Ilja M Nolte, Teresa Nutile, Albertine J Oldehinkel, Ben A Oostra, Paul F O’Reilly, Elin Org, Sandosh Padmanabhan, Walter Palmas, Aarno Palotie, Alison Pattie, Brenda WJH Penninx, Markus Perola, Annette Peters, Ozren Polasek, Peter P Pramstaller, Quang Tri Nguyen, Olli T Raitakari, Rainer Rettig, Kenneth Rice, Paul M Ridker, Janina S Ried, Harriëtte Riese, Samuli Ripatti, Antonietta Robino, Lynda M Rose, Jerome I Rotter, Igor Rudan, Daniela Ruggiero, Yasaman Saba, Cinzia F Sala, Veikko Salomaa, Nilesh J Samani, Antti-Pekka Sarin, Reinhold Schmidt, Helena Schmidt, Nick Shrine, David Siscovick, Albert V Smith, Harold Snieder, Siim Sõber, Rossella Sorice, John M Starr, David J Stott, David P Strachan, Rona J Strawbridge, Johan Sundström, Morris A Swertz, Kent D Taylor, Alexander Teumer, Martin D Tobin, Maciej Tomaszewski, Daniela Toniolo, Michela Traglia, Stella Trompet, Jaakko Tuomilehto, Christophe Tzourio, André G Uitterlinden, Ahmad Vaez, Peter J van der Most, Cornelia M van Duijn, Germaine C Verwoert, Veronique Vitart, Uwe Völker, Peter Vollenweider, Dragana Vuckovic, Hugh Watkins, Sarah H Wild, Gonneke Willemsen, James F Wilson, Alan F Wright, Jie Yao, Tatijana Zemunik, Weihua Zhang, John R Attia, Adam S Butterworth, Daniel I Chasman, David Conen, Francesco Cucca, John Danesh, Caroline Hayward, Joanna MM Howson, Markku Laakso, Edward G Lakatta, Claudia Langenberg, Olle Melander, Dennis O Mook-Kanamori, Colin NA Palmer, Lorenz Risch, Robert A Scott, Rodney J Scott, Peter Sever, Tim D Spector, Pim van der Harst, Nicholas J Wareham, Eleftheria Zeggini, Daniel Levy, Patricia B Munroe, Christopher Newton-Cheh, Morris J Brown, Andres Metspalu, Bruce M. Psaty, Louise V Wain, Paul Elliott, Mark J Caulfield, Padhraig Gormley, Verneri Anttila, Priit Palta, Tune H Pers, Kai-How Farh, Ester Cuenca-Leon, Mikko Muona, Nicholas A Furlotte, Tobias Kurth, Andres Ingason, George McMahon, Lannie Ligthart, Gisela M Terwindt, Mikko Kallela, Tobias M Freilinger, Caroline Ran, Scott G Gordon, Anine H Stam, Stacy Steinberg, Guntram Borck, Markku Koiranen, Lydia Quaye, Hieab H H Adams, Juho Wedenoja, David A Hinds, Julie E Buring, Markus Schürks, Maria Gudlaug Hrafnsdottir, Hreinn Stefansson, Susan M Ring, Brenda W J H Penninx, Markus Färkkilä, Ville Artto, Mari Kaunisto, Salli Vepsäläinen, Rainer Malik, Andrew C Heath, Pamela A F Madden, Nicholas G Martin, Grant W Montgomery, Mitja I Kurki, Mart Kals, Kalle Pärn, Eija Hämäläinen, Hailiang Huang, Andrea E Byrnes, Lude Franke, Jie Huang, Evie Stergiakouli, Phil H Lee, Cynthia Sandor, Caleb Webber, Zameel Cader, Bertram Muller-Myhsok, Stefan Schreiber, Thomas Meitinger, Johan G Eriksson, Kauko Heikkilä, Elizabeth Loehrer, Andre G Uitterlinden, Lynn Cherkas, Audun Stubhaug, Christopher S Nielsen, Minna Männikkö, Evelin Mihailov, Hartmut Göbel, Ann-Louise Esserlind, Anne Francke Christensen, Thomas Folkmann Hansen, Thomas Werge, Jaakko Kaprio, Arpo J Aromaa, Olli Raitakari, M Arfan Ikram, Tim Spector, Marjo-Riitta Järvelin, Christian Kubisch, Michel D Ferrari, Andrea C Belin, Maija Wessman, Arn M J M van den Maagdenberg, George Davey Smith, Kari Stefansson, Nicholas Eriksson, Mark J Daly, Benjamin M Neale, Jes Olesen, Dale R Nyholt, Masato Akiyama, Varinder S. Alg, Joseph P. Broderick, Ben M. Brumpton, Jérôme Dauvillier, Hubert Desal, Christian Dina, Christoph M. Friedrich, Emília I. Gaál-Paavola, Jean-Christophe Gentric, Sven Hirsch, Isabel C. Hostettler, Henry Houlden, Juha E. Jääskeläinen, Marianne Bakke Johnsen, Liming Li, Kuang Lin, Antti Lindgren, Olivier Martin, Koichi Matsuda, Iona Y. Millwood, Olivier Naggara, Mika Niemelä, Joanna Pera, Richard Redon, Guy A. Rouleau, Marie Søfteland Sandvei, Sabine Schilling, Eimad Shotar, Agnieszka Slowik, Chikashi Terao, W. M. Monique Verschuren, Robin G. Walters, David J. Werring, Cristen J. Willer, Daniel Woo, Bradford B. Worrall, Sirui Zhou, Biological Psychology, Amsterdam Reproduction & Development, APH - Mental Health, APH - Methodology, AMS - Sports, AMS - Ageing & Vitality, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Systems Ecology, Sociology and Social Gerontology, Bakker, Mark K., Kanning, Jos P., Abraham, Gad, Martinsen, Amy E., Winsvold, Bendik S., Zwart, John-Anker, Bourcier, Romain, Sawada, Tomonobu, Koido, Masaru, Kamatani, Yoichiro, Morel, Sandrine, Amouyel, Philippe, Debette, Stéphanie, Bijlenga, Philippe, Berrandou, Takiy, Ganesh, Santhi K., Bouatia-Naji, Nabila, Jones, Gregory, Bown, Matthew, Rinkel, Gabriel J. E., Veldink, Jan H., Ruigrok, Ynte M., Girotto, G., All-In Stroke, Hunt, Group, Cadisp, Consortium for Blood Pressure, International, Headache Genetics Consortium, International, Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group, International, Utrecht University [Utrecht], Baker Heart and Diabetes Institute (AUSTRALIA), University of Melbourne, University of Oslo (UiO), Norwegian University of Science and Technology (NTNU), Oslo University Hospital [Oslo], Centre hospitalier universitaire de Nantes (CHU Nantes), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), The University of Tokyo (UTokyo), RIKEN Center for Integrative Medical Sciences [Yokohama] (RIKEN IMS), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Hôpital Universitaire de Genève = University Hospitals of Geneva (HUG), Université de Genève = University of Geneva (UNIGE), Excellence Laboratory LabEx DISTALZ, Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), University of Michigan Medical School [Ann Arbor], University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, University of Otago [Dunedin, Nouvelle-Zélande], University of Leicester, Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 (LNFP), Université de Picardie Jules Verne (UPJV), CHU Amiens-Picardie, HUNT All-In Stroke, CADISP group, International Consortium for Blood Pressure, International Headache Genetics Consortium, International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group: Anne Hege Aamodt, Anne Heidi Skogholt, Ben M Brumpton, Cristen J Willer, Else C Sandset, Espen S Kristoffersen, Hanne Ellekjær, Ingrid Heuch, Jonas B Nielsen, Knut Hagen, Kristian Hveem, Lars G Fritsche, Laurent F Thomas, Linda M Pedersen, Maiken E Gabrielsen, Oddgeir L Holmen, Sigrid Børte, Wei Zhou, Shérine Abboud, Massimo Pandolfo, Vincent Thijs, Didier Leys, Marie Bodenant, Fabien Louillet, Emmanuel Touzé, Jean-Louis Mas, Yves Samson, Sara Leder, Anne Léger, Sandrine Deltour, Sophie Crozier, Isabelle Méresse, Sandrine Canaple, Olivier Godefroy, Maurice Giroud, Yannick Béjot, Pierre Decavel, Elizabeth Medeiros, Paola Montiel, Thierry Moulin, Fabrice Vuillier, Jean Dallongeville, Antti J Metso, Tiina Metso, Turgut Tatlisumak, Caspar Grond-Ginsbach, Christoph Lichy, Manja Kloss, Inge Werner, Marie-Luise Arnold, Michael Dos Santos, Armin Grau, Martin Dichgans, Constanze Thomas-Feles, Ralf Weber, Tobias Brandt, Alessandro Pezzini, Valeria De Giuli, Filomena Caria, Loris Poli, Alessandro Padovani, Anna Bersano, Silvia Lanfranconi, Simone Beretta, Carlo Ferrarese, Giacomo Giacolone, Stefano Paolucci, Philippe Lyrer, Stefan Engelter, Felix Fluri, Florian Hatz, Dominique Gisler, Leo Bonati, Henrik Gensicke, Margareth Amort, Hugh Markus, Jennifer Majersik, Bradford Worrall, Andrew Southerland, John Cole, Steven Kittner, Evangelos Evangelou, Helen R Warren, He Gao, Georgios Ntritsos, Niki Dimou, Tonu Esko, Reedik Mägi, Lili Milani, Peter Almgren, Thibaud Boutin, Jun Ding, Franco Giulianini, Elizabeth G Holliday, Anne U Jackson, Ruifang Li-Gao, Wei-Yu Lin, Jian'an Luan, Massimo Mangino, Christopher Oldmeadow, Bram Peter Prins, Yong Qian, Muralidharan Sargurupremraj, Nabi Shah, Praveen Surendran, Sébastien Thériault, Niek Verweij, Sara M Willems, Jing-Hua Zhao, John Connell, Renée de Mutsert, Alex Sf Doney, Martin Farrall, Cristina Menni, Andrew D Morris, Raymond Noordam, Guillaume Paré, Neil R Poulter, Denis C Shields, Alice Stanton, Simon Thom, Gonçalo Abecasis, Najaf Amin, Dan E Arking, Kristin L Ayers, Caterina M Barbieri, Chiara Batini, Joshua C Bis, Tineka Blake, Murielle Bochud, Michael Boehnke, Eric Boerwinkle, Dorret I Boomsma, Erwin P Bottinger, Peter S Braund, Marco Brumat, Archie Campbell, Harry Campbell, Aravinda Chakravarti, John C Chambers, Ganesh Chauhan, Marina Ciullo, Massimiliano Cocca, Francis Collins, Heather J Cordell, Gail Davies, Martin H de Borst, Eco J de Geus, Ian J Deary, Joris Deelen, Fabiola Del Greco M, Cumhur Yusuf Demirkale, Marcus Dörr, Georg B Ehret, Roberto Elosua, Stefan Enroth, A Mesut Erzurumluoglu, Teresa Ferreira, Mattias Frånberg, Oscar H Franco, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Christian Gieger, Giorgia Girotto, Anuj Goel, Alan J Gow, Vilmundur Gudnason, Xiuqing Guo, Ulf Gyllensten, Anders Hamsten, Tamara B Harris, Sarah E Harris, Catharina A Hartman, Aki S Havulinna, Andrew A Hicks, Edith Hofer, Albert Hofman, Jouke-Jan Hottenga, Jennifer E Huffman, Shih-Jen Hwang, Erik Ingelsson, Alan James, Rick Jansen, Marjo-Riitta Jarvelin, Roby Joehanes, Åsa Johansson, Andrew D Johnson, Peter K Joshi, Pekka Jousilahti, J Wouter Jukema, Antti Jula, Mika Kähönen, Sekar Kathiresan, Bernard D Keavney, Kay-Tee Khaw, Paul Knekt, Joanne Knight, Ivana Kolcic, Jaspal S Kooner, Seppo Koskinen, Kati Kristiansson, Zoltan Kutalik, Maris Laan, Marty Larson, Lenore J Launer, Benjamin Lehne, Terho Lehtimäki, David Cm Liewald, Li Lin, Lars Lind, Cecilia M Lindgren, YongMei Liu, Ruth Jf Loos, Lorna M Lopez, Yingchang Lu, Leo-Pekka Lyytikäinen, Anubha Mahajan, Chrysovalanto Mamasoula, Jaume Marrugat, Jonathan Marten, Yuri Milaneschi, Anna Morgan, Andrew P Morris, Alanna C Morrison, Peter J Munson, Mike A Nalls, Priyanka Nandakumar, Christopher P Nelson, Teemu Niiranen, Ilja M Nolte, Teresa Nutile, Albertine J Oldehinkel, Ben A Oostra, Paul F O'Reilly, Elin Org, Sandosh Padmanabhan, Walter Palmas, Aarno Palotie, Alison Pattie, Brenda Wjh Penninx, Markus Perola, Annette Peters, Ozren Polasek, Peter P Pramstaller, Quang Tri Nguyen, Olli T Raitakari, Rainer Rettig, Kenneth Rice, Paul M Ridker, Janina S Ried, Harriëtte Riese, Samuli Ripatti, Antonietta Robino, Lynda M Rose, Jerome I Rotter, Igor Rudan, Daniela Ruggiero, Yasaman Saba, Cinzia F Sala, Veikko Salomaa, Nilesh J Samani, Antti-Pekka Sarin, Reinhold Schmidt, Helena Schmidt, Nick Shrine, David Siscovick, Albert V Smith, Harold Snieder, Siim Sõber, Rossella Sorice, John M Starr, David J Stott, David P Strachan, Rona J Strawbridge, Johan Sundström, Morris A Swertz, Kent D Taylor, Alexander Teumer, Martin D Tobin, Maciej Tomaszewski, Daniela Toniolo, Michela Traglia, Stella Trompet, Jaakko Tuomilehto, Christophe Tzourio, André G Uitterlinden, Ahmad Vaez, Peter J van der Most, Cornelia M van Duijn, Germaine C Verwoert, Veronique Vitart, Uwe Völker, Peter Vollenweider, Dragana Vuckovic, Hugh Watkins, Sarah H Wild, Gonneke Willemsen, James F Wilson, Alan F Wright, Jie Yao, Tatijana Zemunik, Weihua Zhang, John R Attia, Adam S Butterworth, Daniel I Chasman, David Conen, Francesco Cucca, John Danesh, Caroline Hayward, Joanna Mm Howson, Markku Laakso, Edward G Lakatta, Claudia Langenberg, Olle Melander, Dennis O Mook-Kanamori, Colin Na Palmer, Lorenz Risch, Robert A Scott, Rodney J Scott, Peter Sever, Tim D Spector, Pim van der Harst, Nicholas J Wareham, Eleftheria Zeggini, Daniel Levy, Patricia B Munroe, Christopher Newton-Cheh, Morris J Brown, Andres Metspalu, Bruce M Psaty, Louise V Wain, Paul Elliott, Mark J Caulfield, Padhraig Gormley, Verneri Anttila, Priit Palta, Tonu Esko, Tune H Pers, Kai-How Farh, Ester Cuenca-Leon, Mikko Muona, Nicholas A Furlotte, Tobias Kurth, Andres Ingason, George McMahon, Lannie Ligthart, Gisela M Terwindt, Mikko Kallela, Tobias M Freilinger, Caroline Ran, Scott G Gordon, Anine H Stam, Stacy Steinberg, Guntram Borck, Markku Koiranen, Lydia Quaye, Hieab H H Adams, Terho Lehtimäki, Antti-Pekka Sarin, Juho Wedenoja, David A Hinds, Julie E Buring, Markus Schürks, Paul M Ridker, Maria Gudlaug Hrafnsdottir, Hreinn Stefansson, Susan M Ring, Jouke-Jan Hottenga, Brenda W J H Penninx, Markus Färkkilä, Ville Artto, Mari Kaunisto, Salli Vepsäläinen, Rainer Malik, Andrew C Heath, Pamela A F Madden, Nicholas G Martin, Grant W Montgomery, Mitja I Kurki, Mart Kals, Reedik Mägi, Kalle Pärn, Eija Hämäläinen, Hailiang Huang, Andrea E Byrnes, Lude Franke, Jie Huang, Evie Stergiakouli, Phil H Lee, Cynthia Sandor, Caleb Webber, Zameel Cader, Bertram Muller-Myhsok, Stefan Schreiber, Thomas Meitinger, Johan G Eriksson, Veikko Salomaa, Kauko Heikkilä, Elizabeth Loehrer, Andre G Uitterlinden, Albert Hofman, Cornelia M van Duijn, Lynn Cherkas, Linda M Pedersen, Audun Stubhaug, Christopher S Nielsen, Minna Männikkö, Evelin Mihailov, Lili Milani, Hartmut Göbel, Ann-Louise Esserlind, Anne Francke Christensen, Thomas Folkmann Hansen, Thomas Werge, Jaakko Kaprio, Arpo J Aromaa, Olli Raitakari, M Arfan Ikram, Tim Spector, Marjo-Riitta Järvelin, Andres Metspalu, Christian Kubisch, David P Strachan, Michel D Ferrari, Andrea C Belin, Martin Dichgans, Maija Wessman, Arn M J M van den Maagdenberg, Dorret I Boomsma, George Davey Smith, Kari Stefansson, Nicholas Eriksson, Mark J Daly, Benjamin M Neale, Jes Olesen, Daniel I Chasman, Dale R Nyholt, Aarno Palotie, Masato Akiyama, Varinder S Alg, Sigrid Børte, Joseph P Broderick, Ben M Brumpton, Jérôme Dauvillier, Hubert Desal, Christian Dina, Christoph M Friedrich, Emília I Gaál-Paavola, Jean-Christophe Gentric, Sven Hirsch, Isabel C Hostettler, Henry Houlden, Kristian Hveem, Juha E Jääskeläinen, Marianne Bakke Johnsen, Liming Li, Kuang Lin, Antti Lindgren, Olivier Martin, Koichi Matsuda, Iona Y Millwood, Olivier Naggara, Mika Niemelä, Joanna Pera, Richard Redon, Guy A Rouleau, Marie Søfteland Sandvei, Sabine Schilling, Eimad Shotar, Agnieszka Slowik, Chikashi Terao, W M Monique Verschuren, Robin G Walters, David J Werring, Cristen J Willer, Daniel Woo, Bradford B Worrall, Sirui Zhou, Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, and Admin, Oskar
Subjects: Advanced and Specialized Nursing, Incidence, risk assessment, Smoking/epidemiology, intracranial aneurysm, genetic heterogeneity, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Risk Factors, Intracranial Aneurysm/epidemiology, Humans, Subarachnoid Hemorrhage/epidemiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, genetics, Neurology (clinical), aneurysmal subarachnoid hemorrhage, genetic, Cardiology and Cardiovascular Medicine
Abstract: Background: Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to be used for genetic risk prediction. We constructed a genetic risk score to (1) predict ASAH incidence and IA presence (combined set of unruptured IA and ASAH) and (2) assess its association with patient characteristics. Methods: A genetic risk score incorporating genetic association data for IA and 17 traits related to IA (so-called metaGRS) was created using 1161 IA cases and 407 392 controls from the UK Biobank population study. The metaGRS was validated in combination with risk factors blood pressure, sex, and smoking in 828 IA cases and 68 568 controls from the Nordic HUNT population study. Furthermore, we assessed association between the metaGRS and patient characteristics in a cohort of 5560 IA patients. Results: Per SD increase of metaGRS, the hazard ratio for ASAH incidence was 1.34 (95% CI, 1.20–1.51) and the odds ratio for IA presence 1.09 (95% CI, 1.01–1.18). Upon including the metaGRS on top of clinical risk factors, the concordance index to predict ASAH hazard increased from 0.63 (95% CI, 0.59–0.67) to 0.65 (95% CI, 0.62–0.69), while prediction of IA presence did not improve. The metaGRS was statistically significantly associated with age at ASAH (β=−4.82×10 −3 per year [95% CI, −6.49×10 −3 to −3.14×10 −3 ]; P =1.82×10 −8 ), and location of IA at the internal carotid artery (odds ratio=0.92 [95% CI, 0.86–0.98]; P =0.0041). Conclusions: The metaGRS was predictive of ASAH incidence, although with limited added value over clinical risk factors. The metaGRS was not predictive of IA presence. Therefore, we do not recommend using this metaGRS in daily clinical care. Genetic risk does partly explain the clinical heterogeneity of IA warranting prioritization of clinical heterogeneity in future genetic prediction studies of IA and ASAH.
Published: 2023

2. Occupational Accidents Among Search and Rescue Providers During Mountain Rescue Operations and Training Events

Author: Mario Milani, Giulia Roveri, Marika Falla, Tomas Dal Cappello, and Giacomo Strapazzon
Subjects: Emergency Medicine
Published: 2023

3. Probabilistic-based discrete model for the seismic fragility assessment of masonry structures

Author: Luis C.M. da Silva, Gabriele Milani, and Paulo B. Lourenço
Subjects: Architecture, Building and Construction, Safety, Risk, Reliability and Quality, Civil and Structural Engineering
Published: 2023

4. Modeling of shear-lap tests of flat and curved masonry specimens strengthened by FRCM

Author: Ernesto Grande, Mario Fagone, Tommaso Rotunno, and Gabriele Milani
Subjects: Architecture, Building and Construction, Safety, Risk, Reliability and Quality, Civil and Structural Engineering
Published: 2023

5. Between food fulfillment and income: Can urban agriculture contribute to both?

Author: Oekan S. Abdoellah, Yusep Suparman, Kinanti Indah Safitri, Akhmad Zainal Mubarak, Mira Milani, null Margareth, and Levaldo Surya
Subjects: Ecology, Geography, Planning and Development, Nature and Landscape Conservation, Earth-Surface Processes
Published: 2023

6. Amphotericin B liposomal formulation: applicable preparation methods, challenges, and tips

Author: Rogayeh Seify, Fahimeh Zahednezhad, Parvin Zakeri-Milani, and Hadi Valizadeh
Subjects: Pharmacology, Organic Chemistry, Drug Discovery, Pharmaceutical Science
Published: 2023

7. Ferramentas educativas na promoção da saúde bucal para a terceira idade

Author: Stephanie Hisami Canales Katsuyama, Caroline Milani Caldeira, Maura Sassahara Higasi, Lírian Adriana Maria Pereira da Silva, Nancy Sayuri Uchida, Maria Luiza Hiromi Iwakura Kasai, Hélion Leão Lino Junior, and Tânia Harumi Uchida
Abstract: O objetivo do estudo foi identificar ferramentas educativas que promovam saúde bucal entre os pacientes da terceira idade. Trata-se de uma revisão de literatura, com uma busca sistematizada nas bases de dados, Biblioteca Virtual em Saúde, Scielo e Google Acadêmico, empregando os descritores: saúde bucal, idoso, promoção de saúde, jogos e brinquedos. Os critérios de inclusão foram: estudos qualitativos e relatos de experiências. A busca resultou em 1.108 artigos e após a verificação dos critérios de elegibilidade foram incluídos quatro artigos. Os resultados evidenciaram que as ferramentas educativas utilizadas na promoção da saúde bucal entre os idosos foram: atividades lúdico-educativas, palestras e rodas de conversas, orientação de higiene bucal e distribuição de escovas e cremes dentais. Assim, as ferramentas educativas podem capacitar e apoiar os idosos nas tomadas de decisões a fim de garantir um cuidado seguro, confiável e que promova longevidade com qualidade de vida, bem como auxiliar na manutenção da saúde geral e saúde bucal dos mesmos.
Published: 2023

8. Examining Attentional Biases Elicited by Sexual Stimuli Using MouseView.js: An Online Paradigm to Mimic Eye Movements

Author: Sonia Milani, Thomas Armstrong, Edwin Dalmaijer, Alexander Anwyl-Irvine, and Samantha J. Dawson
Subjects: Gender Studies, History and Philosophy of Science, Sociology and Political Science, General Psychology
Published: 2023

9. Super-Stretchable Resistive Strain Sensor Based on Ecoflex–Gold Nanocomposites

Author: Lorenzo Migliorini, Tommaso Santaniello, Andrea Falqui, and Paolo Milani
Subjects: General Materials Science
Published: 2023

10. Gut Microbiota: a Perspective for Postpartum Depression

Author: Sima Vadaei, Payam Gonbari Milani, Roya Abedi Soleimani, and Azar Abedi Soleimani
Subjects: Advanced and Specialized Nursing, Medical–Surgical Nursing
Abstract: Maternal postpartum depression, one of the most prevalent and incapacitating side effects of motherhood, is frequently underdiagnosed and undertreated. However, treatment results are still far from ideal. It has recently come to light that dietary changes are linked to changes in gut flora, which raises health risks and makes people more susceptible to a number of diseases. The gut microbiota plays a significant regulating role in the progression of psychiatric illnesses such postpartum depression. Probiotics and prebiotics have recently acquired popularity in studies on mental health and disease. In this review, the authors explore the connection between postpartum depression and gut microbiota, risk factors and how probiotic bacteria work to lessen symptoms, as well as the possibility of using probiotic bacteria as a useful postpartum depression therapy component.
Published: 2023

11. Microencapsulated antioxidant stevia fraction fortifies whey protein and enhances its antidiabetic activity

Author: Cynthia Letícia S. Cabeça, Natani Caroline Nogueira, Maria Rosa T. Zorzenon, Antonio Sergio Dacome, Grasiele Scaramal Madrona, Cecília Edna Mareze da Costa, Silvio Claudio da Costa, and Paula Gimenez Milani
Subjects: Food Science
Published: 2023

12. Extracellular vesicles in vaccine development and therapeutic approaches for viral diseases

Author: Parisa Moradi Pordanjani, Azam Bolhassani, Alireza Milani, and Mohammad Hassan Pouriayevali
Subjects: Bioengineering, Applied Microbiology and Biotechnology, Biochemistry
Published: 2023

13. Comparison of Adjuvant Effects of Montanide ISA-720 and Heat Shock Protein 27 in Increasing Immunostimulatory Properties of HIV-1 Nef-Vif Fusion Protein Construct

Author: Azam Bolhassani, Niloofar Khairkhah, Fatemeh Shahhosseini, Elnaz Agi, and Alireza Milani
Subjects: Structural Biology, General Medicine, Biochemistry
Abstract: Introduction:: Effective T-cell-mediated immunity has emerged as an essential component of human immunodeficiency virus-1 (HIV-1) vaccination. Thus, inducing an immune response against HIV proteins such as Nef and Vif, two major accessory proteins with critical roles in HIV pathogenesis and immune evasion, may lead to an effective approach. Aim: Our goal is to evaluate and compare Montanide ISA-720 and heat shock protein 27 in increasing immunostimulatory properties of HIV-1 Nef-Vif fusion protein as a vaccine candidate. Methods: In this study, the nef-vif fusion gene with and without the heat shock protein 27 (hsp27) gene was cloned in the prokaryotic pET24a (+) vector. Then, the recombinant Nef-Vif and Hsp27-Nef- Vif proteins were generated in the E. coli system. Finally, their immunostimulatory properties were evaluated in mice. Indeed, the potency of Hsp27 as an endogenous natural adjuvant was investigated to enhance HIV-1 Nef-Vif antigen-specific immunity compared to Montanide ISA-720 as a commercial adjuvant in protein-based immunization strategy. Results: Our results approved the role of Hsp27 as an effective adjuvant in the stimulation of B- and T-cell immunity. The linkage of Hsp27 to antigen could elicit higher levels of IgG1, IgG2a, IFN-γ, IL- 5 and Granzyme B than antigen mixed with Montanide ISA-720. Moreover, the ratios of IFN-γ/IL-5 and IgG2a/IgG1 were significantly increased in groups receiving Nef-Vif protein + Montanide ISA- 720 and Hsp27-Nef-Vif protein indicating the direction of the immune response pathway toward strong Th1 response. These ratios were higher in the group receiving Hsp27-Nef-Vif protein than in the group receiving Nef-Vif protein + Montanide ISA-720. Conclusion: Our findings suggest that Hsp27 can be used as an effective adjuvant to enhance antigenspecific immune responses in HIV-1 infectious models for therapeutic vaccine development.
Published: 2023

14. SimSpine: A Cost-Effective Spinal Endoscopy Training Prototype for Neurosurgical Residents Skills Training

Author: Manbachan Singh Bedi, Amol Raheja, Varidh Katiyar, Shashwat Mishra, Kanwaljeet Garg, Priya Narwal, Akshay Ganeshkumar, Ravi Sharma, Vivek Tandon, Davide Milani, Franco Servadei, Ashish Suri, and Shashank S. Kale
Subjects: Surgery, Neurology (clinical)
Published: 2023

15. List of Contributors

Author: Dina Abdelsamad, Lindsey Abraham, Yasmin Al-Atrache, Lareb Altaf, Ksenya Badashova, Sonal Batra, Kamilla Beisenova, Keith Boniface, Kiara Brooks, Brandon Chaffay, Aileen Chowdhury, Emmanuel Chukwuma, Sara Cogswell, Margeaux Connealy, Cassidy Craig, Sarah Cronin, Steven Davis, Elizabeth Dearing, Crystal Donelan, Aaran Drake, Eleanor Frye, Christina Gallerani, Carin Gannon, Sara Ashton Garcia, Jason Gray, Alexander Gregory Hastava, Sarah Hocutt, Megan Hoffer, Jenny Huang, Sarah Ingram, Breanne Jacobs, Cody Johnson, Amy Keim, Margaret Klein, Joseph Kunic, Lexington Lemmon, Owen Ligas, Noah Lubin, Rita Manfredi, Maggie McEnery, Jason S. McKay, Robert L. McKinney, Andrew Charles Meltzer, Elise Milani, Natalia Monsalve, Nehal S. Naik, Trent Nayve, John Organick-Lee, Christopher Payette, Ayal Pierce, Margarita Popova, Matthew Pyle, Claudia Ranniger, Stephen Robie, Colleen Roche, Madeleine Rosenstein, Eleanor Rubin, Zeina Saliba, Jordan Selzer, Robert Shesser, Leah Steckler, Ryan Strauss, Alexa Tovsen, Jesús Treviño, Fletcher Vilt, Andzie Warrington, Michael West, Naja Wilson, Mary Taylor Winsten, Samuel Winsten, Julia Xavier, and David Yamane
Published: 2024

16. Disasters and Mass Casualty Events

Author: Jordan Selzer, Elise Milani, Cody Johnson, and Maggie McEnery
Published: 2024

17. OTTERS:a powerful TWAS framework leveraging summary-level reference data

Author: Dai, Qile, Zhou, Geyu, Zhao, Hongyu, Võsa, Urmo, Franke, Lude, Battle, Alexis, Teumer, Alexander, Lehtimäki, Terho, Raitakari, Olli T., Esko, Tõnu, Agbessi, Mawussé, Ahsan, Habibul, Alves, Isabel, Andiappan, Anand Kumar, Arindrarto, Wibowo, Awadalla, Philip, Beutner, Frank, Jan Bonder, Marc, Boomsma, Dorret I., Christiansen, Mark W., Claringbould, Annique, Deelen, Patrick, Favé, Marie-Julie, Frayling, Timothy, Gharib, Sina A., Gibson, Greg, Heijmans, Bastiaan T., Hemani, Gibran, Jansen, Rick, Kähönen, Mika, Kalnapenkis, Anette, Kasela, Silva, Kettunen, Johannes, Kim, Yungil, Kirsten, Holger, Kovacs, Peter, Krohn, Knut, Kronberg, Jaanika, Kukushkina, Viktorija, Kutalik, Zoltan, Lee, Bernett, Loeffler, Markus, Marigorta, Urko M., Mei, Hailang, Milani, Lili, Montgomery, Grant W., Müller-Nurasyid, Martina, Nauck, Matthias, Nivard, Michel G., Penninx, Brenda, Perola, Markus, Pervjakova, Natalia, Pierce, Brandon L., Powell, Joseph, Prokisch, Holger, Psaty, Bruce M., Ripatti, Samuli, Rotzschke, Olaf, Rüeger, Sina, Saha, Ashis, Scholz, Markus, Schramm, Katharina, Seppälä, Ilkka, Slagboom, Eline P., Stehouwer, Coen D. A., Stumvoll, Michael, Sullivan, Patrick, ‘t Hoen, Peter A. C., Thiery, Joachim, Tong, Lin, Tönjes, Anke, van Dongen, Jenny, van Iterson, Maarten, van Meurs, Joyce, Veldink, Jan H., Verlouw, Joost, Visscher, Peter M., Völker, Uwe, Westra, Harm-Jan, Wijmenga, Cisca, Yaghootkar, Hanieh, Yang, Jian, Zeng, Biao, Zhang, Futao, Epstein, Michael P., Yang, Jingjing, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Digital Health, Biological Psychology, Amsterdam Reproduction & Development, APH - Methodology, APH - Personalized Medicine, Internal Medicine, Tampere University, Department of Clinical Chemistry, and Clinical Medicine
Subjects: Multidisciplinary, 1182 Biochemistry, cell and molecular biology, General Physics and Astronomy, 3111 Biomedicine, General Chemistry, Medical Genetics, General Biochemistry, Genetics and Molecular Biology, Medicinsk genetik
Abstract: Most existing TWAS tools require individual-level eQTL reference data and thus are not applicable to summary-level reference eQTL datasets. The development of TWAS methods that can harness summary-level reference data is valuable to enable TWAS in broader settings and enhance power due to increased reference sample size. Thus, we develop a TWAS framework called OTTERS (Omnibus Transcriptome Test using Expression Reference Summary data) that adapts multiple polygenic risk score (PRS) methods to estimate eQTL weights from summary-level eQTL reference data and conducts an omnibus TWAS. We show that OTTERS is a practical and powerful TWAS tool by both simulations and application studies. Godkänd;2023;Nivå 0;2023-04-06 (hanlid);Funder: for more funders see the article https://doi.org/10.1038/s41467-023-36862-w
Published: 2023

18. Analysis of repeated computed tomography scans and cumulative effective dose of patients in a hospital

Author: Ana Luiza Milani, Allan Felipe Fattori Alves, Matheus Alvarez, Samara Pavan Souza, Túlio Guilherme Soares Marques, Marcos Aureliano Araujo Silva, José Carlos Souza Trindade Filho, and Diana Rodrigues Pina
Subjects: General Agricultural and Biological Sciences
Abstract: Computed tomography exams are considered diagnostic imaging exams that generate significant radiation dose to the patient. Justification, optimization, and dose limitation are radiological protection principles used to minimize patient and staff exposure, ensuring the quality of the service provided. The objective of this study was to analyze CT scan data, analyzing the number of exams, the patients' effective cumulated dose, and the repeatability of the exams. The study data covers the 2013 to 2022 period during which a progressive increase was observed in the number of exams performed over time, with exams doubling in this period. The most used Computed Tomography protocols were brain/skull (27.4%), pelvis (17.3%), and abdomen (13.7%) during the study period. Approximately 76.3% of patients have a cumulative dose of less than 25 mSv, while about 1% accumulated more than 100 mSv. The repeatability of CT scans for the same patient over a short period varies, reaching until 17 scans in 30 days for a single patient. The results indicated a necessity to develop strategies for individual dose management methods for the institution’s internal practices. An intervention could be implemented by creating periodically updated handouts and guidelines based on professionals' knowledge.
Published: 2023

19. Physiological Response of a Natural Central Incisor Tooth to Various Loading Conditions: A 3D Finite Element Study

Author: Dipti Nikam and Abbas S. Milani
Subjects: General Medicine
Abstract: This study evaluates the influence of different loading angles and the area of loading on the ensuing stress distribution and the physical response of a natural central incisor tooth, using a 3D finite element analysis. The CAD model of the incisor tooth assembly (including enamel, dentin, periodontal ligament, pulp, gingiva and jaw bone) was subject to an external (chewing) load of 100 N, over four different areas and at four different angles along the vertical. It was observed that the tooth experiences high von-Mises equivalent stresses and high bending when the load applied is closer to the incisal edge of the crown. Also, the stresses on the dentin, in general, increased with the increase in the loading angle regardless of the area of loading; with the highest stress (~70 MPa) generated at 45° angle. The percentage change observed in dentin von-Mises stresses was higher than that of enamel when the loading angle was increased from 0° to 45°, because of the higher stiffness of enamel and structural differences in enamel and dentin. The numerical results indicated that applying loads on incisal edge would simulate a severe loading condition for the incisor tooth.
Published: 2023

20. Failure to post-dilate BeSmooth peripheral stents to adult vessel size diameters during benchside tests

Author: Raymond N. Haddad, Damien Bonnet, and Sophie Malekzadeh-Milani
Subjects: Pediatrics, Perinatology and Child Health, General Medicine, Cardiology and Cardiovascular Medicine
Abstract: Background: Low-profile stent implantation remains a rescue treatment for aortic coarctation and branch pulmonary arteries stenosis in small children. Stent re-expansion to cope with vascular growth remains problematic. Objectives: To evaluate ex vivo feasibility and mechanical behaviour of over-dilating BeSmooth peripheral stents (Bentley InnoMed, Germany). Methods: Three BeSmooth peripheral stents in diameters of 7, 8, and 10 mm were dilated to nominal pressure and then 13 atm. BeSmooth Ø7 × 23 mm was sequentially post-dilated using 12, 14, and 16 mm high-pressure balloons. BeSmooth Ø10 × 57 mm was post-dilated with a 14 mm balloon and then with a 48 mm bare-metal Optimus XXL stent hand-mounted on a 14 mm balloon (stent-in-stent). BeSmooth Ø8 × 57 mm was directly post-dilated with a 48 mm bare-metal Optimus XXL stent hand-mounted on a 16 mm balloon (stent-in-stent). The stents’ diameter and length were measured. Digital inflation pressure was noted. Balloon rupture and stent fracture patterns were closely evaluated. Results: At 20atm pressure, BeSmooth Ø7 × 23 mm shortened to 2 mm forming a 12 mm diameter solid ring circle and the woven balloon ruptured radially. At 10 atm pressure, BeSmooth Ø10 × 57 mm fractured longitudinally in various dispatched breaking points at a diameter of 13 mm without shortening and ruptured the balloon with multiple pinholes. At 10 atm pressure, BeSmooth Ø8 × 57 mm fractured centrally at three different points at a diameter of 11.5 mm without shortening and the balloon broke radially in half. Conclusions: In our benchmark tests, extreme shortening, severe balloon rupture, or unpredictable stent fracture patterns at small balloon diameters limits safe post-dilation of BeSmooth stents beyond 13 mm. BeSmooth stents are not ideal candidates for off-label stent interventions in smaller patients.
Published: 2023

21. Effects of the intensity of interval training on aerobic fitness, body composition and resting metabolic rate of women with overweight or obesity: A randomized trial

Author: Leonardo Vidal Andreato, Alexandro Andrade, Andrew Keech, Valmir da Silva, Walker William Francisco, Felipe Tiburcio Milani, Laura de Souza Genta, and Braulio Henrique Magnani Branco
Subjects: Biophysics, Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine
Abstract: BACKGROUND: Moderate-intensity interval training (MIIT) may be a viable exercise format for improving body composition, aerobic fitness, and health-related variables. OBJECTIVES: This randomized trial aimed to analyze the effect of MIIT or high-intensity interval training (HIIT) on aerobic fitness, body composition variables, and resting metabolic rate (RMR) in women with overweight or obesity. METHODS: 31 sedentary adult women with overweight or obesity performed 7 weeks × 3 weekly sessions of either HIIT or MIIT. Physical and physiological tests were applied before and after training. RESULTS: In both analyses (intention-to-treat and by adherence to the training), aerobic fitness showed a time effect (p= 0.041 and p= 0.015), but without differences between groups (p> 0.05). No group (HIIT vs. MIIT), time (pre vs. post), or interaction effects (group vs. time) were found for RMR, body composition markers (fat mass, body fat percentage, lean mass), or body mass index – BMI (p> 0.05). In addition, MIIT induced a relatively high drop-out rate. CONCLUSIONS: This study suggested that the short-term (7-weeks) interval exercise training was effective for increasing aerobic fitness, and moderate-intensity intervals were as effective as high-intensity intervals. However, neither training format was effective for changing RMR, body composition variables, or BMI of women with overweight or obesity. Clinical trial ID: RBR-9jd7b7.
Published: 2023

22. POVOS INDÍGENAS: MULTICULTURALISMO E RECONHECIMENTO

Author: ANGELA TERESINHA MILANI
Abstract: For many years, indigenous peoples have been the target of a civilization attempt, resulting in their oppression, through an ethnic discrimination, living in a complex and difficult circumstance, which is characterized by situations of poverty and exclusion, where the cultural ethos is not recognized, consequently destructing the original cultural identity of these peoples. In contemporary society, with the ongoing process of globalization, where the prominence of economic development is unleashed over the other dimensions of social life, instead of bringing to light a scenario of cooperation and dialogue between different countries, peoples and cultures, it threatens to constitute a monologue and cultural imposition, urging the need of recognizing the characteristics of each cultural space. In this sense, the proposal is to reflect on the perspectives of indigenous cultures that are strongly disrupted by the unique thinking that was imposed all over the world, which, to be legitimized, uses legal and moral arguments to defend certain universal values. A stereotyped image of indigenous peoples has been established, as if they were an obstacle for the development of our societies, arising an attempt at cultural hegemony. Social conflicts are increasingly related to issues of differences recognition that figure in a highlight position when it comes about the fights for multiculturalism, where one seeks to promote universal respect for shared humanity and esteem for different cultures due to their specificities. The recognition policy that will be discussed works together with the redistribution policies, where one does not replace or exclude the other, in order to stimulate the interaction between differences and protection of human rights, otherwise, the forces that promote inequality and oppression would be reenforced, rather than acting towards the recognition of indigenous peoples.
Published: 2023

23. A visual approach to support process analysts in working with process improvement opportunities

Author: Kateryna Kubrak, Fredrik Milani, and Alexander Nolte
Subjects: Business, Management and Accounting (miscellaneous), Business and International Management
Abstract: PurposeWhen improving business processes, process analysts can use data-driven methods, such as process mining, to identify improvement opportunities. However, despite being supported by data, process analysts decide which changes to implement. Analysts often use process visualisations to assess and determine which changes to pursue. This paper helps explore how process mining visualisations can aid process analysts in their work to identify, prioritise and communicate business process improvement opportunities.Design/methodology/approachThe study follows the design science methodology to create and evaluate an artefact for visualising identified improvement opportunities (IRVIN).FindingsA set of principles to facilitate the visualisation of process mining outputs for analysts to work with improvement opportunities was suggested. Particularly, insights into identifying, prioritising and communicating process improvement opportunities from visual representation are outlined.Originality/valuePrior work focuses on visualisation from the perspectives – among others – of process exploration, process comparison and performance analysis. This study, however, considers process mining visualisation that aids in analysing process improvement opportunities.
Published: 2023

24. NLX-101, a 5-HT1A receptor-biased agonist, improves pattern separation and stimulates neuroplasticity in aged rats

Author: Rafael Pazinatto Aguiar, Lígia Mendes Soares, Mark Varney, Adrian Newman-Tancredi A, Humberto Milani, Jos Prickaerts, Rúbia Maria Weffort de Oliveira, RS: MHeNs - R3 - Neuroscience, and Psychiatrie & Neuropsychologie
Subjects: Aging, F15599, NLX-101, PROTEINS, General Neuroscience, ADULT NEUROGENESIS, F13714, 5-HT 1A receptor, HIPPOCAMPAL NEUROGENESIS, DENTATE GYRUS, Pattern separation, SYNAPTIC PLASTICITY, DEFICITS, COGNITION, Neuroplasticity, Neurology (clinical), Geriatrics and Gerontology, BRAIN, Aged rats, Developmental Biology, NEUROTROPHIC FACTOR
Abstract: 5-HT1A serotonin receptors may play a role in cognitive function changes related to advanced age. Here, we investigated the effects of acute and repeated treatment with NLX-101 (F15599), a postsynaptic 5-HT1A receptor-biased agonist, and F13714, a presynaptic 5-HT1A receptor-biased agonist on spatial object pattern separation (OPS) in aged (22-24 months) rats. Neuroplasticity markers including brain-derived neurotrophic factor, PSD95, synaptophysin, and doublecortin were evaluated in the hippocampus. Un-like younger rats, aged rats were incapable of discriminating any new position of the objects in the arena, reflecting the detrimental effect of aging on pattern separation. However, aged animals treated with NLX-101 showed a significant cognitive improvement in the OPS test, accompanied by increases in hippocampal brain-derived neurotrophic factor and PSD95 protein levels. In contrast, no improvement in OPS performance was observed when aged rats received F13714. Both F13714 and NLX-101 increased the number of newborn neurons in the hippocampi of aged rats. These findings provide a rationale for targeting post-synaptic 5-HT1A as a treatment for cognitive deficits related to aging.(c) 2023 Elsevier Inc. All rights reserved.
Published: 2023

25. Epigenetica e cancro

Author: Ketti Mazzocco and Alessandra Milani
Subjects: Geography, Planning and Development, Management, Monitoring, Policy and Law
Abstract: Negli ultimi anni vi è stato un incremento dell'incidenza e della prevalen- za del tumore in Italia e nel mondo. Anche il tasso di mortalità post-pan- demico è in aumento rispetto agli anni precedenti. La CoViD-19 ha, infatti, creato un ritardo diagnostico e un inizio di cura tardivo, riducendo così in molti casi la probabilità di guarigione. Nei siti ufficiali dedicati all'informazione sul cancro in Italia (Aimac, Airc), nei report di associazioni nazionali come l'Associazione Italiana Oncologia Medica (Aiom) e nella pagina "prevenzione dei tumori" del Ministero della Salute sono ri- portati i fattori di rischio della malattia oncologica, ma non sono citati gli aspetti psicologici nonostante le evidenze sempre più numerose sul loro significativo contributo. La seguente revisione narrativa ha lo scopo di evidenziare, grazie ai complessi meccanismi epigenetici, l'influenza sulla carcinogenesi dei fattori di rischio più noti e condivisi come gli stili di vita e l'ambiente, ma anche di quelli meno pubblicizzati, come il contesto sociale e la percezione del sé. Questa complessa multifattorialità della malattia oncologica può rappresentare per i professionisti sanitari l'op- portunità di riorientare lo sguardo di cura in ottica Pnei promuovendo un approccio integrato.
Published: 2023

26. Data Anonymization With Diversity Constraints

Author: Yu Huang, Mostafa Milani, and Fei Chiang
Subjects: Computational Theory and Mathematics, Data anonymization, Computer science, 020204 information systems, 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, 02 engineering and technology, Data mining, computer.software_genre, computer, Computer Science Applications, Information Systems, Diversity (business)
Published: 2023

27. A GARANTIA DO ACESSO AO DIREITO A SAÚDE DAS COMUNIDADES INDÍGENAS DA AMAZÔNIA BRASILEIRA EM TEMPOS DE PANDEMIA DA COVID-19

Author: Solange Venâncio Milani and Adriano Fernandes Ferreira
Abstract: O presente trabalho analisou os direitos fundamentais, em específico o direito à saúde, dos povos indígenas da Amazônia brasileira frente ao contexto da pandemia da COVID-19. A pesquisa teve como base o ordenamento jurídico brasileiro, por meio da aplicação dos direitos fundamentais, tendo como enfoque o direito à saúde dos indígenas da Amazônia brasileira diante do contexto de pandemia e como o Estado e as autoridades governamentais atuaram em relação a essa problemática para sanar os empecilhos para isso, a fim de fazer valer o que está previsto em muitos mecanismos normativos. A metodologia da pesquisa utilizada possui caráter teórico-analítico através de uma conciliação entre os métodos qualitativos e quantitativos. Posteriormente, foi demonstrado um levantamento de dados de pesquisas estatísticas que foram realizadas por instituições como a Articulação dos Povos Indígenas do Brasil (APIB) e a coordenação das Organizações indígenas da Amazônia Brasileira (COIAB) durante os períodos mais críticos de contaminação e óbitos causados pela COVID-19 entre a população indígena, através dessa análise comparativa notou-se que havia uma subnotificação de casos. Por fim, concluiu-se que apesar das medidas tomadas durante o período para o combate a pandemia da COVID-19 o dever de cooperação entre as instituições foi insuficiente.
Published: 2023

28. Main factors influencing long-term outcomes of liver transplantation in 2022

Author: Elisa Fuochi, Lorenzo Anastasio, Erica Nicola Lynch, Claudia Campani, Gabriele Dragoni, Stefano Milani, Andrea Galli, and Tommaso Innocenti
Subjects: Hepatology
Published: 2023

29. Coming to practice differently in the workplace: a practice architectures exploration of workplace learning in times of change

Author: Amanda L. Lizier, Oriana Milani Price, and Susanne Francisco
Subjects: 1301 Education Systems, Education
Abstract: The recent pandemic resulted in significant changes in workplaces that saw people come to live and work differently. What was previously experienced and understood to be the ‘workplace’, along with associated work practices, has shifted and the construct of the workplace has become multiple as more people work remotely. We propose that these changes have also shifted practices of working, providing significant insights into how learning may be happening, not in ‘workplaces’ but rather in reformed ‘sites’ of work. To explore changed work and learning practices in sites of work, we adopt the Theory of Practice Architectures to explore how workers in managing roles learned to practise their work differently in newly formed sites of work. This article provides evidence from semi-structured interviews with 12 managers during the changes wrought during the pandemic in Australia using the ‘Interview to the double’ approach. We highlight how the managers understood their changes in work and shows empirically how the concept of ‘workplace learning’ requires a reconceptualization of learning that rejects a focus on learning as defined by process and instead adopts a practice-based definition of learning as ‘coming to practice differently’.
Published: 2023

30. Financiamento e operacionalização da política pública de assistência social a partir da Emenda Constitucional 95/2016 na regional de Pato Branco, Paraná

Author: Deise Thais Natsume Carolo, Leonardo Dresch Eberhardt, Daniel Regis Oliveira, Luciméli Nogueira do Amaral, Francieli da Costa Colla, and Maria Luiza Milani
Subjects: General Medicine
Abstract: O objetivo do estudo é analisar o financiamento e operacionalização da política de assistência social a partir da Emenda Constitucional 95 de 2016, relacionados ao desenvolvimento dos municípios da 7ª Regional de Assistência Social sediada em Pato Branco, Paraná. A metodologia incluiu a triangulação de métodos quantitativos e qualitativos, com pesquisa documental e entrevistas. O grupo amostral foi constituído por dois contadores e seis gestores dos municípios da Regional com os três maiores e os três menores Índices de Desenvolvimento Humano Municipal. Os resultados indicam que os principais problemas e desafios relacionados ao financiamento e operacionalização da assistência social a partir da Emenda, e agravados durante a pandemia de Covid-19, dizem respeito à imprecisão orçamentária, insuficiência de recursos, gestão da força de trabalho, manutenção da estrutura física e atendimento das necessidades sociais da população. Historicamente subfinanciada, a assistência social pode apresentar dificuldades ainda maiores relacionadas ao teto de gastos imposto pela Emenda. Palavras-chave: Políticas Públicas. Assistência Social. Políticas Sociais. Desenvolvimento Regional.
Published: 2023

31. Preparation and potential application of amino-functionalized titanosilicates to removal of Th(IV) in aqueous solutions: optimization using response surface methodology (RSM)

Author: Saeid Alamdar Milani, Rasoul Neishabori Salehi, Peyman Manouchehri, and Mohammad Faryadi
Subjects: Physical and Theoretical Chemistry
Abstract: Mesoporous titanosilicates (TiSil) with a size of almost 25 nm were prepared by an alkali-assisted hydro-thermal route, as an choice for developing efficient adsorbents of Th(IV) ions. TiSil were functionalized with the amino functional group (-NH2) from 3-aminopropyltriethoxysilane (APTES) by post-preparation method. The obtained amino-grafted titanosilicates (TiSilNH2) were characterized by Scanning Electron Microscopy (SEM), Brunauer–Emmett–Teller (BET), X-ray Diffraction (XRD) and Fourier-Transform Infrared Spectroscopy (FTIR) techniques. Adsorption of Th(IV) ions on TiSilNH2 was examined in aqueous solution. Response surface methodology (RSM) based on central composite design (CCD) was applied to optimize the four essential process variables namely initial pH and initial concentration of Th(IV) ions of aqueous solution, amount of adsorbent, and adsorption process temperature for the Th(IV) removal. The adequacy of the model was investigated, and it was deemed to be statistically significant. The optimal predicted adsorption capacity of TiSilNH2 for Th(IV) ions was 83.04 mg/g and the actual value was 84.8 mg/g. The equilibrium adsorption data were fitted to Langmuir, Freundlich, Dubinin–Radushkevich and Temkin isotherm models. The equi-librium data were best re-presented by Langmuir isotherm model, showing maximum monolayer adsorption capacity of 87.71 mg/g. The thermodynamic parameters indicated that the Th(IV) adsorption on the TiSilNH2 was a spontaneous, and endo-thermic process at the studied temperatures and occurred via physisorption. Adsorbent recovery by using 0.5 M HNO3 solution for adsorbent reuse indicated that the adsorbent was regenerable and could be employed frequently.
Published: 2023

32. Early spontaneous closure of large arterial ducts in two term neonates with Ebstein anomaly after failed attempts of transcatheter closure

Author: Raymond N. Haddad, Sophie Malekzadeh-Milani, and Damien Bonnet
Subjects: Pediatrics, Perinatology and Child Health, General Medicine, Cardiology and Cardiovascular Medicine
Abstract: In neonatal Ebstein’s anomaly of the tricuspid valve, prolonged ductal patency in patients without anatomic pulmonary valve atresia can be deleterious. Circular shunts may develop in patients with different degrees of pulmonary and tricuspid insufficiency. Closure of the arterial duct may result in haemodynamic improvement in particular scenarios. The transcatheter approach is a valuable closure alternative despite some technical difficulties in large-sized arterial ducts and low birth weight neonates. Herein, we report on two consecutive term newborns with Ebstein’s anomaly and large arterial ducts in whom mechanical stimulus of the arterial duct during failed attempts of transcatheter closure led after two days to definitive closure followed by good clinical outcomes.
Published: 2023

33. JMJD6 Shapes a Pro-tumor Microenvironment via ANXA1-Dependent Macrophage Polarization in Breast Cancer

Author: Bianca Cioni, Silvia Ratti, Annamaria Piva, Irene Tripodi, Matteo Milani, Francesca Menichetti, Tiziana Langella, Laura Botti, Loris De Cecco, Claudia Chiodoni, Daniele Lecis, and Mario P. Colombo
Subjects: Cancer Research, Oncology, Molecular Biology
Abstract: Breast cancer is the most common type of cancer in women worldwide, with the luminal subtype being the most widespread. Although characterized by better prognosis compared with other subtypes, luminal breast cancer is still considered a threatening disease due to therapy resistance, which occurs via both cell- and non–cell-autonomous mechanisms. Jumonji domain-containing 6, arginine demethylase and lysine hydroxylase (JMJD6) is endowed with a negative prognostic value in luminal breast cancer and, via its epigenetic activity, it is known to regulate many intrinsic cancer cell pathways. So far, the effect of JMJD6 in molding the surrounding microenvironment has not been explored. Here, we describe a novel function of JMJD6 showing that its genetic inhibition in breast cancer cells suppresses lipid droplet formation and ANXA1 expression, via estrogen receptor alpha and PPARα modulation. Reduction of intracellular ANXA1 results in decreased release in the tumor microenvironment (TME), ultimately preventing M2-type macrophage polarization and tumor aggressiveness. Implications: Our findings identify JMJD6 as a determinant of breast cancer aggressiveness and provide the rationale for the development of inhibitory molecules to reduce disease progression also through the remodeling of TME composition.
Published: 2023

34. Graded Cardiac Response Criteria for Patients With Systemic Light Chain Amyloidosis

Author: Eli Muchtar, Angela Dispenzieri, Brendan Wisniowski, Giovanni Palladini, Paolo Milani, Giampaolo Merlini, Stefan Schönland, Kaya Veelken, Ute Hegenbart, Susan M. Geyer, Shaji K. Kumar, Efstathios Kastritis, Meletios A. Dimopoulos, Michaela Liedtke, Ronald Witteles, Vaishali Sanchorawala, Raphael Szalat, Heather Landau, Erica Petrlik, Suzanne Lentzsch, Alexander Coltoff, Joan Bladé, Maria Teresa Cibeira, Oliver Cohen, Darren Foard, Ashutosh Wechalekar, and Morie A. Gertz
Subjects: Cancer Research, Oncology
Abstract: PURPOSE Binary cardiac response assessment using cardiac biomarkers is prognostic in light chain amyloidosis. Previous studies suggested four-level cardiac responses using N-terminal prohormone of brain natiuretic peptide improves prognostic prediction. This study was designed to validate graded cardiac response criteria using N-terminal prohormone of brain natiuretic peptide/brain natiuretic peptide. PATIENTS AND METHODS This retrospective, multicenter study included patients with light chain amyloidosis who achieved at least a hematologic partial response (PR) and were evaluable for cardiac response. Four response criteria were tested on the basis of natriuretic peptide response depth: cardiac complete response (CarCR), cardiac very good partial response (CarVGPR), cardiac PR (CarPR), and cardiac no response (CarNR). Response was classified as best response and at fixed time points (6, 12, and 24 months from therapy initiation). The study primary outcome was overall survival. RESULTS 651 patients were included. Best CarCR, CarVGPR, CarPR, and CarNR were achieved in 16%, 26.4%, 22.9%, and 34.7% of patients, respectively. Patients in cardiac stage II were more likely to achieve CarCR than patients in cardiac stage IIIA and IIIB (22% v 13.5% v 3.2%; P < .001). A deeper cardiac response was associated with a longer survival (5-year overall survival 93%, 79%, 65%, and 33% for CarCR, CarVGPR, CarPR, and CarNR, respectively; P < .001). Fixed time-point analyses and time-varying covariates Cox regression analysis, to minimize survivorship bias, affirmed the independent survival advantage of deeper cardiac responses. Four-level response performed better than two-level response as early as 12 months from therapy initiation. CONCLUSION Graded cardiac response criteria allow better assessment of cardiac improvement compared with the traditional binary response system. The study re-emphasizes the importance of early diagnosis, which increases the likelihood of deep cardiac responses.
Published: 2023

35. Evaluation of Snowfall Retrieval Performance of GPM Constellation Radiometers Relative to Spaceborne Radars

Author: Yalei You, George Huffman, Veljko Petkovic, Lisa Milani, John X. Yang, Ardeshir Ebtehaj, Sajad Vahedizade, and Guojun Gu
Subjects: Atmospheric Science
Abstract: This study assesses the level-2 snowfall retrieval results from 11 passive microwave radiometers generated by the version 5 Goddard profiling algorithm (GPROF) relative to two spaceborne radars: CloudSat Cloud Profiling Radar (CPR) and Global Precipitation Measurement (GPM) Ku-band Precipitation Radar (KuPR). These 11 radiometers include six conical scanning radiometers [Advanced Microwave Scanning Radiometer for the Earth Observing System (AMSR-E), its successor sensor AMSR2, GPM Microwave Imager (GMI), and three Special Sensor Microwave Imager/Sounders (SSMIS)] and five cross-track scanning radiometers [Advanced Technology Microwave Sounder (ATMS) and four Microwave Humidity Sounders (MHS)]. Results show that over ocean conical scanning radiometers have better detection and intensity estimation skills than cross-track sensors, likely due to the availability and usage of the low-frequency channels (e.g., 19 and 37 GHz). Over land, AMSR-E and AMSR2 have noticeably worse performance than other sensors, primarily due to the lack of higher than 89-GHz channels (e.g., 150, 166, and 183 GHz). Over both land and ocean, all 11 sensors severely underestimate the snowfall intensity, which propagates to the widely used level 3 precipitation product [i.e., Integrated Multi-satelliteE Retrievals for GPM (IMERG)]. These conclusions hold regardless of using either KuPR or CPR as the reference, though the statistical metrics vary quantitatively. The conclusions drawn from these comparisons apply solely to the GPROF version 5 algorithm.
Published: 2023

36. Heilungsverlauf und Behandlungsergebnisse nach akutem Supinationstrauma des oberen Sprunggelenkes

Author: Anica Kilper, Ann-Kathrin Lederer, Laura Niklaus, Thomas Milani, Ronny Langenhan, Ludwig Schütz, and Niklas Reimers
Subjects: Orthopedics and Sports Medicine, Physical Therapy, Sports Therapy and Rehabilitation
Published: 2023

37. Design of an Ultrasonic Transducer Encapsulation for High-Temperature Applications

Author: Mina Torabi Milani, Jenna Del Fatti, Kimberley Orna, Yixin Zhang, and Anthony Sinclair
Subjects: Mechanics of Materials, Mechanical Engineering, General Materials Science
Abstract: A novel approach to designing the encapsulation for a high-temperature ultrasonic transducer to be capable of continuous operation over a temperature range of 25 to 650 °C is proposed. The transducer’s active element is a heavily damped lithium niobate disc of 3 MHz resonance frequency, operating in pulse-echo mode. The initial encapsulation design is developed based on the geometrical, thermal, mechanical, electrical, and ultrasonic requirements. Two finite element modeling systems are developed to analyze the thermal-induced stresses in the transducer at low and high temperatures as well as its ultrasonic performance. The simulation results are used to optimize the design before manufacturing a transducer prototype. The prototype is tested at room and elevated temperatures to verify performance.
Published: 2023

38. Comparison of the effect of NaOCL, curcumin, and EDTA on differentiation, proliferation, and adhesion of dental pulp stem cells

Author: Vahid Zand, Amin Salem Milani, Carolyn Primus, Marzie Aghazade, Hadi Mokhtari, Sabete Bagheri Sabzevar, and Pardis Tehranchi
Subjects: Otorhinolaryngology, General Dentistry
Published: 2023

39. Influence of dyke-type causeway on Urmia Lake (NW Iran); insights from water physico-chemical parameters seasonal (2019) changes

Author: Ali Mohammadi, Georg Schwamborn, Amaneh Kaveh-Firouz, Attila Çiner, Razyeh Lak, Alireza Salehipour Milani, and Demet Biltekin
Subjects: Environmental Engineering, Environmental Chemistry, Management, Monitoring, Policy and Law, Water Science and Technology, Civil and Structural Engineering
Published: 2023

40. Choice experiment to assess consumer attributes for a pharmaceutical product

Author: Vinicius Claudino Bica, Vera Lúcia Milani Martins, Mauricio Raymundo Belleza, Fernando Henrique Lermen, and Márcia Elisa Soares Echeveste
Subjects: Marketing, Health Policy
Abstract: Purpose This study aims to identify the appropriate combination of attributes that must be present to deliver value in a new product for a pharmaceutical enterprise. Design/methodology/approach The application object was the Metronidazole analytical standard, using choice experiments to product attributes and price. Findings The practical results indicate that consumer value anticipation allows entry into the market with higher competitiveness. Originality/value Conceptually, it uses a value delivery approach, generally applied to large companies, in a case aimed at enterprises. In practice, for the enterprise studied, the value anticipation by the consumer allows entry into the market with higher competitiveness.
Published: 2023

41. Effect of Different Mixing Methods on Physicochemical Properties of Mineral Trioxide Aggregate: A Systematic Review

Author: Amin Salem Milani, Faraz Radmand, Behrad Rahbani, Mahdi Hadilou, Farnaz Haji Abbas Oghli, Fatemeh Salehnia, and Milad Baseri
Subjects: General Dentistry
Abstract: Background. Mineral trioxide aggregate (MTA) is a commonly used endodontic biomaterial. The physicochemical properties of MTA have a crucial role in designating clinical outcome, and different factors can affect these properties. Various methods have been used for mixing MTA, including manual, mechanical, and ultrasonic. The aim of this systematic review was to evaluate the effect of different mixing methods on the physicochemical properties of MTA. Materials and Methods. Electronic databases including PubMed, Embase, Web of Science, and Scopus were searched up to May 2022. In order to cover gray literature, the ProQuest and Google Scholar databases were also searched to detect theses and conference proceedings. For quality assessment of the included studies, we used a modified version of the Cochrane risk of bias tool for randomized controlled trials (RCTs). Experimental studies which had assessed at least one property of MTA and compared at least two different mixing methods of MTA were included in this study. All animal studies, reviews, case reports, and case series were excluded. Results. Fourteen studies were included. The results showed that the ultrasonic mixing method significantly improved some MTA characteristics, including microhardness, flowability, solubility, setting time, and porosity. However, the mechanical mixing method improved other properties including flowability, solubility, push-out bond strength, and hydration. The manual mixing method showed inferior results compared to other mixing methods in terms of microhardness, flowability, solubility, setting time, push-out bond strength, porosity, and hydration. Different mixing methods had a similar effect on compressive strength, sealing ability, pH and calcium ion release, volume change, film thickness, and flexural strength of MTA. Conclusion. Mechanical and ultrasonic mixing methods are superior to the manual mixing method in terms of improving physicochemical properties of MTA. No report of selection bias and varieties in methodologies were limitations of evidence.
Published: 2023

42. Analysis Of Impact The Human Resource Management On Entrepreneur Organizations

Author: Septian Hadi Pratama, Try Junanto, Ai Suminar, and Isha Milani
Abstract: The human resources aspect is one of the most needed parts and also includes the needs of the community where with this human resource base a little as much as being able to develop aspects of one's own skills and potential and carry out performance processes in a business environment. Related to this, this literature review discusses human resources applied in the business sector and human resource behavior applied in organizations. This aspect of human resources is a little bit as it has begun to be applied and accepted in various industries, just like other performances. Therefore, in this literature review, it will raise aspects of human resources used in the field of business organization. This study uses a form of literature study research by applying several journals that discuss human resources in an organization, based on journal searches through several journal search sites. These journals were selected using the keyword criteria available in this study. Then, after the selection of criteria is completed. So next, it will use drawing conclusions from various journals and strengthened by theories drawn from various references. In the results of the study, several conclusions were obtained, the results of which were as follows; (1) Human resource aspects have been widely used and utilized in organizational structures. This is because with human resources, it will improve the quality of performance in the organization; (2) the influence brought by human resources is also nothing but can affect the social aspects that exist in society and become an economic driver in the business sector. Thus, this aspect of human resources is very widely applied.
Published: 2023

43. Determining Relationships Strategic Human Resources Management Practices And Employee Commitment

Author: Septian Hadi Pratama, Try Junanto, Ai Suminar, and Isha Milani
Abstract: Relationship management is a strategy in which an organization maintains an ongoing level of engagement with its audience.Due to high involvement of human resource management (HRM), it has been a challenge for the organization to manage the external turbulence like war or government policy changes.Employee commitment is considered a key factor in achieving organizational goals.Employee commitment is one of the indicators of success in implementing strategic human resource management practices. In addition, organizational commitment is also stated as an antecedent of various indicators of organizational success.The main purpose of the article is to investigate the relationship between strategic HRM (SHRM) practices and employee commitment (EC) The paper is prepared using a literature review method sourced from textbooks and articles containing both concepts and empirical results. Articles obtained from sciencedirect, MDPI and googlescholar. The results are presented in narrative form. The results of this study are in determining the relationship between strategic human resource management practices and employee commitment has a direct impact on employee commitment. Employee commitment also serves to mediate the relationship between important human resource management practices and various indicators of organizational success, including those related to human resource development and sustainable competitive advantage.
Published: 2023

44. A Single-Atom Upgrade to Polydicyclopentadiene

Author: Benjamin Godwin, Monir H. Anvari, Tina Olfatbakhsh, Mahshid Mahbod, Abbas S. Milani, Gino A. DiLabio, and Jeremy E. Wulff
Subjects: Inorganic Chemistry, Polymers and Plastics, Organic Chemistry, Materials Chemistry
Published: 2023

45. Phantom comparison for MRI quality control tests according to manufacturers and national standards

Author: Matheus Alvarez, Samara Pavan Souza, Allan Felipe Fattori Alves, Ana Luiza Milani, Túlio Guilherme Soares Marques, Marcos Aureliano Araújo Silva, José Carlos Souza Trindade Filho, and Diana Rodrigues de Pina
Subjects: Marketing, Pharmacology, Organizational Behavior and Human Resource Management, Strategy and Management, Drug Discovery, Pharmaceutical Science
Abstract: Quality control tests are mandatory and essential to monitor Magnetic Resonance Imaging equipment. These assist in determining improper functioning or parameters below established reference levels. The objective of this study was to perform quality control tests in magnetic resonance imaging equipment and to compare their methodology with both FLUKE and KONEX phantoms. Different protocols were used for their evaluation, including the American Association of Physics in Medicine, the American College of Radiologists, and the Brazilian National Health Surveillance Agency. In this study, we demonstrated the results for the most critical tests: slice thickness accuracy, slice position accuracy, high-contrast spatial resolution, low-contrast resolution, magnetic field, and slice thickness uniformity. The results are that, although both phantom objects are efficient for carrying out the tests required in Brazilian regulations, the KONEX phantom consumes less time, as it requires less to image all its structures. The FLUKE phantoms need a longer acquisition time to obtain all test structures and object images. Nevertheless, the results obtained in both are within limits required by Brazilian regulations and limits suggested by the manufacturers' manuals. This work is expected to be a basis for other physicians and services using similar phantoms.
Published: 2023

46. Dal trauma alla resilienza: una ricerca sull'expressive writing con giovani adulti

Author: Luca Milani, Alessia Stefanachi, Elena Camisasca, Paola Di Blasio, and Sarah Miragoli
Subjects: General Psychology
Abstract: Il trauma è una "ferita dell'anima", un'esperienza destabilizzante rispetto alla consuetudine, che disorganizza la mente di chi lo vive. I ricordi non trattati di un trauma sono spesso frammentati, disorganizzati e possono essere facilmente attivati sotto forma di pensieri intrusivi per cui i soggetti traumatizzati sperimentano varie forme di disagio psicologico. L'intervento di scrittura espressiva si è dimostrato essere un valido strumento come supporto nelle situazioni di stress evidenziando un generalizzato effetto positivo sulla salute. La scrittura espressiva, traducendo i pensieri e le emozioni traumatiche in linguaggio, aiuta i soggetti traumatizzati a dare un senso agli eventi sconvolgenti, a gestire le emozioni negative e migliora le loro connessioni con il mondo sociale. Questa ricerca si è posta l'obiettivo di verificare l'effetto di un protocollo di scrittura espressiva in un contesto non clinico, rappresentato da un campione di giovani adulti studenti universitari ed in particolare, ha inteso studiare gli effetti della scrittura espressiva nel mitigare eventuali problematiche psicologiche legate a eventi stressanti e/o traumatici.I risultati hanno confermato una discreta efficacia del protocollo di scrittura espressiva soprattutto nel sostenere un potenziamento delle risorse di coping personali e di adattamento rispetto agli esiti degli eventi stressanti vissuti.
Published: 2023

47. Detailed EMT-Type Load Modeling for Power System Dynamic and Harmonic Studies

Author: Maryam Torabi Milani, Bahram Khodabakhchian, and Jean Mahseredjian
Subjects: Energy Engineering and Power Technology, Electrical and Electronic Engineering
Published: 2023

48. A first update on mapping the human genetic architecture of COVID-19

Author: COVID-19 Host Genetics Initiative, Pathak, GA, Karjalainen, J, Stevens, C, Neale, BM, Daly, M, Ganna, A, Andrews, SJ, Kanai, M, Cordioli, M, Polimanti, R, Harerimana, N, Pirinen, M, Liao, RG, Chwialkowska, K, Trankiem, A, Balaconis, MK, Nguyen, H, Solomonson, M, Veerapen, K, Wolford, B, Roberts, G, Park, D, Ball, CA, Coignet, M, McCurdy, S, Knight, S, Partha, R, Rhead, B, Zhang, M, Berkowitz, N, Gaddis, M, Noto, K, Ruiz, L, Pavlovic, M, Hong, EL, Rand, K, Girshick, A, Guturu, H, Baltzell, AH, Niemi, MEK, Rahmouni, S, Guntz, J, Beguin, Y, Pigazzini, S, Nkambule, L, Georges, M, Moutschen, M, Misset, B, Darcis, G, Guiot, J, Azarzar, S, Gofflot, S, Claassen, S, Malaise, O, Huynen, P, Meuris, C, Thys, M, Jacques, J, Leonard, P, Frippiat, F, Giot, J-B, Sauvage, A-S, Frenckell, CV, Belhaj, Y, Lambermont, B, Nakanishi, T, Morrison, DR, Mooser, V, Richards, JB, Butler-Laporte, G, Forgetta, V, Li, R, Ghosh, B, Laurent, L, Belisle, A, Henry, D, Abdullah, T, Adeleye, O, Mamlouk, N, Kimchi, N, Afrasiabi, Z, Rezk, N, Vulesevic, B, Bouab, M, Guzman, C, Petitjean, L, Tselios, C, Xue, X, Afilalo, J, Afilalo, M, Oliveira, M, Brenner, B, Brassard, N, Durand, M, Schurr, E, Lepage, P, Ragoussis, J, Auld, D, Chassé, M, Kaufmann, DE, Lathrop, GM, Adra, D, Hayward, C, Glessner, JT, Shaw, DM, Campbell, A, Morris, M, Hakonarson, H, Porteous, DJ, Below, J, Richmond, A, Chang, X, Polikowski, H, Lauren, PE, Chen, H-H, Wanying, Z, Fawns-Ritchie, C, North, K, McCormick, JB, Glessner, JR, Gignoux, CR, Wicks, SJ, Crooks, K, Barnes, KC, Daya, M, Shortt, J, Rafaels, N, Chavan, S, Timmers, PRHJ, Wilson, JF, Tenesa, A, Kerr, SM, D’Mellow, K, Shahin, D, El-Sherbiny, YM, von Hohenstaufen, KA, Sobh, A, Eltoukhy, MM, Nkambul, L, Elhadidy, TA, Abd Elghafar, MS, El-Jawhari, JJ, Mohamed, AAS, Elnagdy, MH, Samir, A, Abdel-Aziz, M, Khafaga, WT, El-Lawaty, WM, Torky, MS, El-shanshory, MR, Yassen, AM, Hegazy, MAF, Okasha, K, Eid, MA, Moahmed, HS, Medina-Gomez, C, Ikram, MA, Uitterlinden, AG, Mägi, R, Milani, L, Metspalu, A, Laisk, T, Läll, K, Lepamets, M, Esko, T, Reimann, E, Naaber, P, Laane, E, Pesukova, J, Peterson, P, Kisand, K, Tabri, J, Allos, R, Hensen, K, Starkopf, J, Ringmets, I, Tamm, A, Kallaste, A, Alavere, H, Metsalu, K, Puusepp, M, Batini, C, Tobin, MD, Venn, LD, Lee, PH, Shrine, N, Williams, AT, Guyatt, AL, John, C, Packer, RJ, Ali, A, Free, RC, Wang, X, Wain, LV, Hollox, EJ, Bee, CE, Adams, EL, Palotie, A, Ripatti, S, Ruotsalainen, S, Kristiansson, K, Koskelainen, S, Perola, M, Donner, K, Kivinen, K, Kaunisto, M, Rivolta, C, Bochud, P-Y, Bibert, S, Boillat, N, Nussle, SG, Albrich, W, Quinodoz, M, Kamdar, D, Suh, N, Neofytos, D, Erard, V, Voide, C, Friolet, R, Vollenweider, P, Pagani, JL, Oddo, M, zu Bentrup, FM, Conen, A, Clerc, O, Marchetti, O, Guillet, A, Guyat-Jacques, C, Foucras, S, Rime, M, Chassot, J, Jaquet, M, Viollet, RM, Lannepoudenx, Y, Portopena, L, Bochud, PY, Desgranges, F, Filippidis, P, Guéry, B, Haefliger, D, Kampouri, EE, Manuel, O, Munting, A, Papadimitriou-Olivgeris, M, Regina, J, Rochat-Stettler, L, Suttels, V, Tadini, E, Tschopp, J, Van Singer, M, Viala, B, Boillat-Blanco, N, Brahier, T, Hügli, O, Meuwly, JY, Pantet, O, Gonseth Nussle, S, Bochud, M, D’Acremont, V, Estoppey Younes, S, Albrich, WC, Cerny, A, O’Mahony, L, von Mering, C, Frischknecht, M, Kleger, G-R., Filipovic, M, Kahlert, CR, Wozniak, H, Negro, TR, Pugin, J, Bouras, K, Knapp, C, Egger, T, Perret, A, Montillier, P, di Bartolomeo, C, Barda, B, de Cid, R, Carreras, A, Moreno, V, Kogevinas, M, Galván-Femenía, I, Blay, N, Farré, X, Sumoy, L, Cortés, B, Mercader, JM, Guindo-Martinez, M, Torrents, D, Garcia-Aymerich, J, Castaño-Vinyals, G, Dobaño, C, Gori, M, Renieri, A, Mari, F, Mondelli, MU, Castelli, F, Vaghi, M, Rusconi, S, Montagnani, F, Bargagli, E, Franchi, F, Mazzei, MA, Cantarini, L, Tacconi, D, Feri, M, Scala, R, Spargi, G, Nencioni, C, Bandini, M, Caldarelli, GP, Canaccini, A, Ognibene, A, D’Arminio Monforte, A, Girardis, M, Antinori, A, Francisci, D, Schiaroli, E, Scotton, PG, Panese, S, Scaggiante, R, Monica, MD, Capasso, M, Fiorentino, G, Castori, M, Aucella, F, Biagio, AD, Masucci, L, Valente, S, Mandalà, M, Zucchi, P, Giannattasio, F, Coviello, DA, Mussini, C, Tavecchia, L, Crotti, L, Rizzi, M, Rovere, MTL, Sarzi-Braga, S, Bussotti, M, Ravaglia, S, Artuso, R, Perrella, A, Romani, D, Bergomi, P, Catena, E, Vincenti, A, Ferri, C, Grassi, D, Pessina, G, Tumbarello, M, Pietro, MD, Sabrina, R, Luchi, S, Furini, S, Dei, S, Benetti, E, Picchiotti, N, Sanarico, M, Ceri, S, Pinoli, P, Raimondi, F, Biscarini, F, Stella, A, Zguro, K, Capitani, K, Tanfoni, M, Fallerini, C, Daga, S, Baldassarri, M, Fava, F, Frullanti, E, Valentino, F, Doddato, G, Giliberti, A, Tita, R, Amitrano, S, Bruttini, M, Croci, S, Meloni, I, Mencarelli, MA, Rizzo, CL, Pinto, AM, Beligni, G, Tommasi, A, Sarno, LD, Palmieri, M, Carriero, ML, Alaverdian, D, Busani, S, Bruno, R, Vecchia, M, Belli, MA, Mantovani, S, Ludovisi, S, Quiros-Roldan, E, Antoni, MD, Zanella, I, Siano, M, Emiliozzi, A, Fabbiani, M, Rossetti, B, Bergantini, L, D’Alessandro, M, Cameli, P, Bennett, D, Anedda, F, Marcantonio, S, Scolletta, S, Guerrini, S, Conticini, E, Frediani, B, Spertilli, C, Donati, A, Guidelli, L, Corridi, M, Croci, L, Piacentini, P, Desanctis, E, Cappelli, S, Verzuri, A, Anemoli, V, Pancrazzi, A, Lorubbio, M, Miraglia, FG, Venturelli, S, Cossarizza, A, Vergori, A, Gabrieli, A, Riva, A, Paciosi, F, Andretta, F, Gatti, F, Parisi, SG, Baratti, S, Piscopo, C, Russo, R, Andolfo, I, Iolascon, A, Carella, M, Merla, G, Squeo, GM, Raggi, P, Marciano, C, Perna, R, Bassetti, M, Sanguinetti, M, Giorli, A, Salerni, L, Parravicini, P, Menatti, E, Trotta, T, Coiro, G, Lena, F, Martinelli, E, Mancarella, S, Gabbi, C, Maggiolo, F, Ripamonti, D, Bachetti, T, Suardi, C, Parati, G, Bottà, G, Domenico, PD, Rancan, I, Bianchi, F, Colombo, R, Barbieri, C, Acquilini, D, Andreucci, E, Segala, FV, Tiseo, G, Falcone, M, Lista, M, Poscente, M, Vivo, OD, Petrocelli, P, Guarnaccia, A, 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Susanna, Meloni, Ilaria, Mencarelli, Maria Antonietta, Rizzo, Caterina Lo, Pinto, Anna Maria, Beligni, Giada, Tommasi, Andrea, Sarno, Laura Di, Palmieri, Maria, Carriero, Miriam Lucia, Alaverdian, Diana, Busani, Stefano, Bruno, Raffaele, Vecchia, Marco, Belli, Mary Ann, Mantovani, Stefania, Ludovisi, Serena, Quiros-Roldan, Eugenia, Antoni, Melania Degli, Zanella, Isabella, Siano, Matteo, Emiliozzi, Arianna, Fabbiani, Massimiliano, Rossetti, Barbara, Bergantini, Laura, D’Alessandro, Miriana, Cameli, Paolo, Bennett, David, Anedda, Federico, Marcantonio, Simona, Scolletta, Sabino, Guerrini, Susanna, Conticini, Edoardo, Frediani, Bruno, Spertilli, Chiara, Donati, Alice, Guidelli, Luca, Corridi, Marta, Croci, Leonardo, Piacentini, Paolo, Desanctis, Elena, Cappelli, Silvia, Verzuri, Agnese, Anemoli, Valentina, Pancrazzi, Alessandro, Lorubbio, Maria, Miraglia, Federica Gaia, Venturelli, Sophie, Cossarizza, Andrea, Vergori, Alessandra, Gabrieli, Arianna, Riva, Agostino, Paciosi, Francesco, 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F., Nadkarni, Girish N., Do, Ron, O’Reilly, Paul, Huckins, Laura M., Ferreira, Manuel A. R., Abecasis, Goncalo R., Leader, Joseph B., Cantor, Michael N., Justice, Anne E., Carey, Dave J., Chittoor, Geetha, Josyula, Navya Shilpa, Kosmicki, Jack A., Horowitz, Julie E., Baras, Ari, Gass, Matthew C., Yadav, Ashish, Mirshahi, Tooraj, Hottenga, Jouke Jan, Bartels, Meike, de geus, Eco E. J. C., Nivard, Michel M. G., Verma, Anurag, Ritchie, Marylyn D., Rader, Daniel, Li, Binglan, Verma, Shefali S., Lucas, Anastasia, Bradford, Yuki, Abedalthagafi, Malak, Alaamery, Manal, Alshareef, Abdulraheem, Sawaji, Mona, Massadeh, Salam, AlMalik, Abdulaziz, Alqahtani, Saleh, Baraka, Dona, Harthi, Fawz Al, Alsolm, Ebtehal, Safieh, Leen Abu, Alowayn, Albandary M., Alqubaishi, Fatimah, Mutairi, Amal Al, Mangul, Serghei, Almutairi, Mansour, Aljawini, Nora, Albesher, Nour, Arabi, Yaseen M., Mahmoud, Ebrahim S., Khattab, Amin K., Halawani, Roaa T., Alahmadey, Ziab Z., Albakri, Jehad K., Felemban, Walaa A., Suliman, Bandar A., Hasanato, Rana, Al-Awdah, Laila, Alghamdi, Jahad, AlZahrani, Deema, AlJohani, Sameera, Al-Afghani, Hani, AlDhawi, Nouf, AlBardis, Hadeel, Alkwai, Sarah, Alswailm, Moneera, Almalki, Faisal, Albeladi, Maha, Almohammed, Iman, Barhoush, Eman, Albader, Anoud, Alotaibi, Sara, Alghamdi, Bader, Jung, Junghyun, fawzy, Mohammad S., Alrashed, May, Zeberg, Hugo, Nkambul, Lindo, Frithiof, Robert, Hultström, Michael, Lipcsey, Miklo, Tardif, Nicola, Rooyackers, Olav, Grip, Jonathan, Maricic, Tomislav, Helgeland, Øyvind, Magnus, Per, Trogstad, Lill-Iren S., Lee, Yunsung, Harris, Jennifer R., Mangino, Massimo, Spector, Tim D., Emma, Duncan, Moutsianas, Louka, Caulfield, Mark J., Scott, Richard H., Kousathanas, Athanasio, Pasko, Dorota, Walker, Susan, Stuckey, Alex, Odhams, Christopher A., Rhodes, Daniel, Fowler, Tom, Rendon, Augusto, Chan, Georgia, Arumugam, Prabhu, Karczewski, Konrad J., Martin, Alicia R., Wilson, Daniel J., Spencer, Chris C. A., Crook, Derrick W., Wyllie, David H., O’Connell, Anne Marie, Atkinson, Elizabeth G., Tsuo, Kristin, Baya, Nikola, Turley, Patrick, Gupta, Rahul, Walters, Raymond K., Palmer, Duncan S., Sarma, Gopal, Cheng, Nathan, Lu, Wenhan, Churchhouse, Claire, Goldstein, Jacqueline I., King, Daniel, Seed, Cotton, Daly, Mark J., Finucane, Hilary, Bryant, Sam, Satterstrom, F. Kyle, Band, Gavin, Earle, Sarah G., Lin, Shang-Kuan, Arning, Nicola, Koelling, Nil, Armstrong, Jacob, Rudkin, Justine K., Callier, Shawneequa, Cusick, Caroline, Soranzo, Nicole, Zhao, Jing Hua, Danesh, John, Angelantonio, Emanuele Di, Butterworth, Adam S., Sun, Yan V., Huffman, Jennifer E., Cho, Kelly, O’Donnell, Christopher J., Tsao, Phil, Gaziano, J. Michael, Peloso, Gina, Ho, Yuk-Lam, Smieszek, Sandra P., Polymeropoulos, Christo, Polymeropoulos, Vasilio, Polymeropoulos, Mihael H., Przychodzen, Bartlomiej P., Fernandez-Cadenas, Israel, Planas, Anna M., Perez-Tur, Jordi, Llucià-Carol, Laia, Cullell, Natalia, Muiño, Elena, Cárcel-Márquez, Jara, DeDiego, Marta L., Iglesias, Lara Lloret, Soriano, Alex, Rico, Veronica, Agüero, Daiana, Bedini, Josep L., Lozano, Francisco, Domingo, Carlo, Robles, Veronica, Ruiz-Jaén, Francisca, Márquez, Leonardo, Gomez, Juan, Coto, Eliecer, Albaiceta, Guillermo M., García-Clemente, Marta, Dalmau, David, Arranz, Maria J., Dietl, Beatriz, Serra-Llovich, Alex, Soler, Pere, Colobrán, Roger, Martín-Nalda, Andrea, Martínez, Alba Parra, Bernardo, David, Rojo, Silvia, Fiz-López, Aida, Arribas, Elisa, de la Cal-Sabater, Paloma, Segura, Tomá, González-Villa, Esther, Serrano-Heras, Gemma, Martí-Fàbregas, Joan, Jiménez-Xarrié, Elena, de Felipe Mimbrera, Alicia, Masjuan, Jaime, García-Madrona, Sebastian, Domínguez-Mayoral, Anna, Villalonga, Joan Montaner, Menéndez-Valladares, Paloma, Chasman, Daniel I., Sesso, Howard D., Manson, JoAnn E., Buring, Julie E., Ridker, Paul M., Franco, Giulianini, Davis, Lea, Lee, Sulggi, Priest, Jame, Sankaran, Vijay G., van Heel, David, Biesecker, Le, Kerchberger, V. Eric, Baillie, J. Kenneth, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Biological Psychology, APH - Mental Health, AMS - Sports, AMS - Ageing & Vitality, APH - Methodology, Mccurdy, Shannon, Mccormick, Joseph B., Macarthur, Daniel, Maclaughlin, Bev, Lefaive, Jonathon, Almalik, Abdulaziz, Alzahrani, Deema, Aljohani, Sameera, Aldhawi, Nouf, Albardis, Hadeel, Fawzy, Mohammad S., Dediego, Marta L., Stem Cell Aging Leukemia and Lymphoma (SALL), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), University of Zurich, COVID-19 Host Genetics Initiative, Barcelona Supercomputing Center, COVID-19 Genetics Initiative, including authors, Institute for Molecular Medicine Finland, and Data Science Genetic Epidemiology Lab
Subjects: Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC], Quantitative Trait Loci, MUC5B PROMOTER POLYMORPHISM, Genome-wide association studies, COVID-19 (Malaltia), UFSP13-7 Evolution in Action: From Genomes to Ecosystems, COVID-19 (Disease), Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA, SDG 3 - Good Health and Well-being, Humans, genetics, Genetic variation, Genomes, Medicinsk genetik, 1000 Multidisciplinary, Multidisciplinary, Chromosome Mapping, COVID-19, Human Genetics, 10124 Institute of Molecular Life Sciences, covid-19, 3121 General medicine, internal medicine and other clinical medicine, 570 Life sciences, biology, Medical Genetics
Abstract: Matters arising from: Mapping the human genetic architecture of COVID-19 Original Article published on 08 July 2021 https://www.nature.com/articles/s41586-021-03767-x The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity. Here we present meta-analyses bringing together 60 studies from 25 countries (Fig. 1 and Supplementary Table 1) for three COVID-19-related phenotypes: (1) individuals critically ill with COVID-19 on the basis of requiring respiratory support in hospital or who died as a consequence of the disease (9,376 cases, of which 3,197 are new in this data release, and 1,776,645 control individuals); (2) individuals with moderate or severe COVID-19 defined as those hospitalized due to symptoms associated with the infection (25,027 cases, 11,386 new and 2,836,272 control individuals); and (3) all cases with reported SARS-CoV-2 infection regardless of symptoms (125,584 cases, 76,022 new and 2,575,347 control individuals). Most studies have reported results before the roll out of the COVID-19 vaccination campaign. An overview of the study design is provided in Supplementary Fig. 1. We found a total of 23 genome-wide significant loci (P
Published: 2022

49. Oxygen uptake efficiency slope measured by cardiopulmonary exercise testing: applicability analysis of the available prediction equations in a Brazilian healthy sample

Author: J G P O Milani, M Milani, G F B Cipriano, and G Cipriano Junior
Subjects: Epidemiology, Cardiology and Cardiovascular Medicine
Abstract: Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Background Oxygen uptake efficiency slope (OUES) measured by cardiopulmonary exercise testing (CPET) is a measure derived from submaximal oxygen uptake values and has prognostic significance in heart failure patients. Measured values are compared to reference standards for an adequate individual assessment. However, current reference values prediction equations have applicability limitations due to differences in ergometer and sample characteristics (age range and nationatilies), which may impact external validation, as international heterogeneities in peak oxygen uptake values have already been demonstrated by Milani et al. and Peterman et al. Purpose To analyze the applicability of the available prediction equations for OUES in a healthy Brazilian sample from the Midwest region. Methods Cross-sectional study of subjects assessed by treadmill CPET in the Brazilian Midwest region between January/2011 to March/2020. The inclusion criteria were CPET performed on a treadmill in healthy subjects aged 20 years or older, and with respiratory exchange ratio ≥ 1.0. The exclusion criteria were any history of cardiovascular or pulmonary disease, presence of cardiovascular risk factors (such as hypertension, diabetes mellitus, current smoking, and obesity) and abnormalities on CPET. The following available prediction equations were used for comparisons with the measured OUES: 1) Buys et al. from Belgium/Netherlands; 2) Hollemberg et al. from United States; 3) Sun et al. from United States; 4) Brazilian prediction equations calculated in our same sample using sex, age and anthropometric variables. Statistical comparisons between measured and predicted OUES were performed using Spearman correlation test and Bland-Altman agreement analysis. Results During the study period, 7,843 CPETs were performed and included for eligibility. After applying the inclusion and exclusion criteria, 3,544 assessments of healthy individuals were included (1,574 women; 1,970 men; age 20 to 80 years). All correlations between measured and predicted values were significant, with rho ranging from 0.325 to 0.396 in females and from 0.391 to 0.450 in males (Figure 1). The mean errors by the Bland-Altman agreement analysis were heterogeneous between the OUES predition equations, with better results in our Brazilian equation. Greater bias were observed in the equation by Sun et al. for both sexes, in the equation from Buys et al. for females and in the equation by Hollemberg et al. for males (Figure 2). Conclusions The applicability analysis of the international prediction equations for OUES revealed great heterogeneity, limiting the external validation of the available equations, and highlighting the importance of using country-specific reference values for OUES to ensure a correct individual evaluation.
Published: 2023

50. Peak oxygen uptake during treadmill cardiopulmonary exercise testing: applicability analysis of the FRIEND registry prediction equation in a Brazilian healthy sample

Author: M Milani, J G P O Milani, G F B Cipriano, and G Cipriano Junior
Subjects: Epidemiology, Cardiology and Cardiovascular Medicine
Abstract: Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Background Peak oxygen uptake (VO2peak) measured by cardiopulmonary exercise testing (CPET) is an important marker for health, physical performance and cardiovascular prognosis. Measured values are compared to reference standards for an adequate individual assessment. However, regional and international heterogeneities for VO2peak values have already been demonstrated by Milani, which may limit the external validation of the predictive equations developed in different nationalities. One of these equations was developed in an American population sample (FRIEND Registry) by Myers, but this equation has never been evaluated for portability in a population sample from the Brazilian Midwest region. Purpose To analyze the applicability of the FRIEND registry prediction equation for treadmill VO2peak in a healthy Brazilian sample from the Midwest region. Methods Cross-sectional study of subjects assessed by CPET in the Brazilian Midwest region between January/2011 to March/2020. The inclusion criteria were CPET performed on a treadmill in healthy subjects aged 20 years or older, and with respiratory exchange ratio ≥ 1.0. The exclusion criteria were any history of cardiovascular or pulmonary disease, presence of cardiovascular risk factors (such as hypertension, diabetes mellitus, current smoking, and obesity) and abnormalities on CPET. Variables were described as median and interquartile range. Statistical comparisons between measured and predicted VO2peak were performed using Spearman correlation test, Wilcoxon signed rank test, and Bland-Altman agreement analysis. Results During the study period, 7,843 CPET were performed and included for eligibility. After applying the inclusion and exclusion criteria, 3,544 assessments of healthy individuals were included (1,574 women; 1,970 men; age 20 to 80 years). The measured and predicted VO2peak were, respectively, 29.4 (25.1; 33.9) and 33.1 (29.5; 36.2) mL/kg/min in females, and 39.4 (34.3; 43.9) and 42.2 (39.1; 45.0) mL/kg/min in males, with significant differences (p < 0.0001). Correlations were significant (p < 0.0001) for both sexes (rho = 0.418 in women and 0.432 in men) (Figure 1). The mean error by the Bland-Altman agreement analysis was similar in both sexes, with a bias of -2.96 mL/kg/min (95% limits of agreement: -14.96 to 9.04 ) in females and a bias of -2.78 mL/kg/min (95% limits of agreement: - 15.39 to 9.83) in males (Figure 2). Conclusions The median values of the measured VO2peak were lower than the predicted values for both sexes, with a significant mean error, which limits the applicability of the FRIEND registry prediction equation in the Brazilian Midwest region population and highlights the international heterogeneity of the variable.
Published: 2023

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