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Purpose To report the etiology, clinical presentation, and morphology of congenital cataract in a tertiary care center. Methods It is a prospective cohort study conducted at L V Prasad Eye Institute, Hyderabad. All children with congenital cataract ≤ 12 months of age that required surgical intervention between August 2015 and July 2016 were included in the study. 109 such patients were subjected to meticulous history taking, pedigree charting, ocular, and systemic examination, B-scan, TORCH testing, clinical photographs, pediatrician consult and blood tests, which included serum calcium, serum phosphorous and urine for reducing sugars. Results The mean age of presentation was 4.1 months (±2.6 months) and both the genders were equally affected (P = 0.49). Eighty-five patients (77.9%) presented with bilateral cataracts while 24 patients had a unilateral presentation (22.1%). The common morphological presentation was either a total or a nuclear cataract, both variants noticed in 47 patients (43.1%). TORCH infections were responsible for a maximum (37 patients, 33.4%) number of cases followed by familial (20 patients, 18%) and developmental anomalies (11 patients, 10.1%) while the total number of idiopathic cases were 24% (27 patients). Eighteen patients (16.5%) had congenital heart defects and the majority (16 patients, 88.9%) of these had positive TORCH titres. Conclusion Familial cataract and those possibly due to TORCH are still the predominant cause of congenital cataract in this series-highlighting the role of vaccination and preventive measures.

Purpose: To present the case of a 9-year-old child with bilateral posterior subcapsular cataract developed through steroid treatment for acute lymphoblastic leukemia. Cataract surgery with trifocal intraocular lens implantation was performed in both eyes. Observations: Uncorrected distance visual acuity increased from +0.3 and + 0.4 logMAR preoperatively to 0.00 and + 0.04 logMAR after surgery. Binocular uncorrected values for intermediate and near visual acuity were −0.04 logMAR and 0.02 logMAR after surgery, respectively. The patient did not report side effects like halos or glare and was able to participate in his daily activities (school and sports) without spectacles. Conclusions and Importance: This report represents the first description of a bilateral implantation of trifocal intraocular lenses in a pediatric cataract case with restoration of visual function in far, intermediate and near distance. Trifocal intraocular lenses to compensate for the loss of accommodation can be an option in selected cases of children with cataract. Keywords: Pediatric cataract surgery, Trifocal IOL, Leukemia, Steroid-induced cataract

WOS: 000429421300002, PubMed ID: 29576890, Objectives: The aim of this study was to evaluate the outcomes of pediatric developmental cataract surgery with primary intraocular lens (IOL) implantation. Materials and Methods: Patients between 2 and 16 years old who underwent cataract surgery with primary IOL implantation were retrospectively evaluated. Age at time of surgery, pre-and postoperative best corrected visual acuities, postoperative ocular complications, and any accompanying ocular pathologies were obtained from the patients' charts. Mean refractive changes and degree of myopic shift were analyzed according to the age groups. Operated eyes were also compared with the fellow eyes in unilateral cases. Results: A total of 101 eyes of 65 patients were included. The average age at time of surgery was 76 +/- 40 months and the average follow-up period was 44 +/- 30 months. Among the 78 eyes that could be assessed for visual acuity improvement, 66 (84.6%) of them showed >= 2 lines of improvement. The difference in the mean refractive change between the 2-5 years old and 8-16 years old age groups was found to be statistically significant. However, the mean refractive change per year was not found to be significant between the same age groups. In unilateral cases, the operated eyes showed a greater myopic change than the fellow eyes, with no statistically significant difference. The most common postoperative complication was visual axis opacity. Conclusion: Good visual outcomes can be achieved following pediatric cataract surgery with primary IOL implantation. Optic axis opacities were the most common postoperative complications. Overall, refractive changes following surgery are inevitable, and more prominent in younger age groups.

Background:Anterior lens opacities (ALO) are found in 3-14% of pediatric patients with cataracts. No clear guidelines exist in the management and treatment of these cataracts.Objective:To evaluate pediatric patients with anterior lens opacities and assess rate of amblyopia and need for surgery over time.Methods:A retrospective chart review was performed on patients with unilateral and bilateral anterior lens opacities (ALOs) seen between January 2008 and December 2014. Size, location, and type of ALO were noted. Refractive error, necessity for treatment of amblyopia, and interventions were recorded.Results:A total of 31 patients were included in the study. 17 patients had unilateral ALOs and 14 had bilateral ALOs. The majority of the cataracts (90.3%) were centrally located. The most common type of cataract was the polar type of cataract and the vast majority (48.4%) was < 1mm in size. 38.7% of patients had concurrent ocular conditions and 9.7% had systemic associations. 28.6% of patients with bilateral cataracts and 35.3% of the patients with unilateral cataracts were treated for amblyopia. Three patients required cataract surgery.Conclusion:About half of anterior lens opacities are less than 1mm in size and the majority are of the polar type. Risk of amblyopia in these patients is higher than in the general population. Anisometropia is the most common cause of amblyopia. Ocular associations are seen at a relatively high frequency and systemic associations can occur but are uncommon. The need for surgical intervention is infrequent; however, growth of ALOs and associated cortical changes may be risk factors for surgery.

Purpose: To present the case of a 6-year-old child who presented with a traumatic cataract and was treated with trifocal toric intra-ocular lens implantation. Observations: The child's uncorrected distance visual acuity improved from +0.7 logMAR preoperatively to 0.00 logMAR after cataract surgery, with spectacle independence and no reported side effects Conclusions and importance: In carefully selected pediatric patients with traumatic cataracts, trifocal toric intra-ocular lenses may offer some benefit over standard monofocal lenses Keywords: Pediatric cataract surgery, Trifocal toric IOL, Traumatic cataract

Purpose: To assess the outcome of under-correction of intraocular lens (IOL) power in pediatric cataract surgery. Methods: We collected clinical data of 103 patients (181 eyes), all aged ≤15 years, who had undergone cataract surgery by a surgeon during 2006–2016. The mean duration of follow-up was 73 ± 38 months (range: 24–108). IOL power was calculated by Hoffer Q formula in axial length (AL) 10 years old. Results: The mean age of all children at surgery time was 5.85 ± 4.56 years (range: 1–178 months). There was a mean myopic shift of −6.379 D in the ≤1 year, −5.532 in the 1–3, −3.194 in the 3–5, −2.301 in the 5–7, −1.06 in the 7–9, −1.567 in the 9–10, and 0.114 in the >10-year-old age group. In 125 eyes (69.1%) of 181, the final SE was between −2 and +2 D, and 21 eyes (11.6%) achieved the goal of emmetropization. Mean best-corrected visual acuity logarithm of the minimum angle of the resolution was 0.30 in children ≤1 year, 0.39 in 1–3, 0.21 in 3–5, 0.18 in 5–7, 0.14 in 7–9, 0.16 in 9–10, and 0.11 in children >10 years old. Conclusion: This study shows a larger myopic shift in younger children. Using our approach, all age groups could finally achieve acceptable final refraction.

Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina Introdução: As cataratas congénitas constituem a principal causa tratável de cegueira a nível mundial, uma vez que provocam ambliopia irreversível na ausência de tratamento adequado e atempado. Apesar dos avanços na sua abordagem, continua a ser uma cirurgia marcada por uma elevada taxa de complicações pós-operatórias. A opacificação do eixo visual é uma complicação major desta cirurgia. A capsulorrexis circular contínua posterior e a vitrectomia anterior são duas técnicas usadas para a prevenção desta complicação, mas o seu impacto não se encontra devidamente esclarecido e é questionado por alguns autores.Objectivo: Avaliar o impacto da inclusão de capsulorrexis circular contínua posterior e de vitrectomia anterior na prevenção da opacificação do eixo visual na cirurgia da catarata congénita.Materiais e métodos: A partir de uma população de doentes operados no Centro Hospitalar da Universidade de Coimbra (n=143), e aplicando critérios de exclusão, obteve-se o grupo de estudo (n=79). Procedeu-se a uma análise retrospectiva não intervencional do grupo. Foi feita a sua caracterização, tendo em conta o sexo, idade aquando da cirurgia, lateralidade, morfologia das cataratas e complicações registadas no seguimento pós-operatório. Os doentes foram, posteriormente, distribuídos por 3 faixas etárias e de acordo com a técnica cirúrgica realizada. Comparou-se a incidência de complicações pós-operatórias, nomeadamente de opacificação do eixo visual e formação de membranas inflamatórias pós-operatórias, entre os subgrupos.Resultados: A complicação cirúrgica registada mais frequentemente foi a opacificação do eixo visual, que ocorreu em 16,5% (n=13) dos doentes, seguida de estrabismo (15,2%; n=12), formação de membrana inflamatória pós-operatória (11,4%; n=9) e glaucoma (7,6%; n=6). A incidência das complicações pós-operatórias descritas foi significativamente superior em doentes que realizaram capsulorrexis posterior sem vitrectomia anterior, face aos doentes que realizaram capsulorrexis posterior com vitrectomia anterior (p=0,011). Não foi estabelecida nenhuma relação entre a idade aquando da operação e a probabilidade de desenvolver complicações pós-operatórias.A incidência de opacificação do eixo visual foi significativamente inferior (p

Aim To compare visual prognoses and postoperative adverse events of congenital cataract surgery performed at different times and using different surgical approaches. Methods In this prospective, randomized controlled trial, we recruited congenital cataract patients aged 3mo or younger before cataract surgery. Sixty-one eligible patients were randomly assigned to two groups according to surgical timing: a 3-month-old group and a 6-month-old group. Each eye underwent one of three randomly assigned surgical procedures, as follows: surgery A, lens aspiration (I/A); surgery B, lens aspiration with posterior continuous curvilinear capsulorhexis (I/A+PCCC); and surgery C, lens aspiration with posterior continuous curvilinear capsulorhexis and anterior vitrectomy (I/A+PCCC+A-Vit). The long-term best-corrected visual acuity (BCVA) and the incidence of complications in the different groups were compared and analyzed. Results A total of 57 participants (114 eyes) with a mean follow-up period of 48.7mo were included in the final analysis. The overall logMAR BCVA in the 6-month-old group was better than that in the 3-month-old group (0.81±0.28 vs 0.96±0.30; P=0.02). The overall logMAR BCVA scores in the surgery B group were lower than the scores in the A and C groups (A: 0.80±0.29, B: 1.02±0.28, and C: 0.84±0.28; P=0.007). A multivariate linear regression revealed no significant relationships between the incidence of complications and long-term BCVA. Conclusion It might be safer and more beneficial for bilateral total congenital cataract patients to undergo surgery at 6mo of age than 3mo. Moreover, with rigorous follow-up and timely intervention, the postoperative complications in these patients are treatable and do not compromise visual outcomes.

Visual axis opacification (VAO) occurs in up to 40% of pediatric patients after cataract surgery withintraocular lens implantation(IOL) even with a primary posterior capsulotomy (PPC). In both children and adult group, opacification does obscure the visual axis. However, in children after PPC, there is no capsule. Hence, the terminology VAO is used in children rather than posterior capsular opacification. This opacification is caused by a proliferation of epithelial cells on the posterior capsule or anterior vitreous face and can hinder the optical image quality needed for normal visual development. The rate of epithelial mitotic activity is higher in children compared to adult. It can be managed by Yag laser or surgical membranectomy, the latter is preferable. International and national published articles were systematically reviewed on aetio-pathogenesis, surgical techniques and equipment, type and material of IOL, and management of VAO in children operated for cataract. Author's experience was also included to write manuscript. VAO is frequent complication following cataract surgery in pediatric patients. Age of cataract patients, surgical technique and type and materials of IOL are most common influencing factor for VAO. Immediate management with advance equipment of VAO reduces the incidence for development of irreversible stimulation deprivation amblyopia. Keywords: pediatric cataract; pediatric cataract surgery; visual axis opacification.

ObjectiveTo report our operative experience with precision pulse capsulotomy (PPC) for anterior capsulotomy in a paediatric cataract series.Methods and analysisThis study is a retrospective interventional, descriptive series of consecutive paediatric eyes (≤16 years) undergoing cataract surgery using PPC. Surgical time and the time required to perform PPC was recorded. Any intraoperative and postoperative adverse events were noted. Postoperatively, visual acuity, anterior segment examination and intraocular pressure (IOP) were recorded for all children at day 1, 1 week and 1 month.Results21 eyes of 14 patients were included in the study, with the median age at surgery of 6.0 years (IQR; 5-7.75, range=1–16 years). Male to female ratio was 11:3. 13 eyes had lamellar cataract, 3 eyes had total cataract, 2 had posterior subcapsular cataract, 2 had traumatic cataract, while 1 eye had sutural cataract. Median surgical time was 26 min (IQR 21-32) and median PPC time was 75.0 secs (IQR 56-86.5). The anterior capsulotomy was round and complete in most cases, except in one case due to faulty suction. All patients underwent a successful in the bag implantation of intraocular lens with capsulotomy margins overlapping the optic edges in 19 eyes (90%). Median PPC size was 5.54 mm (n=9, IQR 5.39 -5.75) which was slightly larger than expected. None of the cases had any intraoperative or postoperative adverse events with no radial tears of capsulotomy. Postoperatively, the mean final follow-up was 5.71+3.20 weeks.ConclusionTo conclude PPC can be used as an alternative to manual continuous curvilinear capsulorhexis in paediatric cataract surgery producing round well- centred and strong capsulotomy with an easier learning curve.

Objectives: To evaluate visual and functional outcome of bilateral pediatric cataract surgery with intraocular lens implantation in Kabgayi Eye Unit, Rwanda. Methods: Surgical, pre-, and postoperative data of bilateral pediatric cataract surgery cases performed between 1999 and 2007 were collected from the notes. During a prospective follow-up visit in 2008 full eye examination was done, including best corrected visual acuity (BCVA) assessment and refraction. Functional vision in daily life was assessed using a questionnaire. Results: The follow-up examination was attended by 108 children (56.5% girls, participation rate 87.8%). Mean age at the time of surgery was 6.6 years (SD 4.6, range 0-19). Cataract was noticed ≤ 3 months in 83.7% (n = 77). Mean delay between start of symptoms and operation date was 4.9 years (SD 4.0, range 0-16 years). Preoperative blindness was present in 79.1% of children (n = 68). Posterior capsulotomy and vitrectomy were performed in 161 eyes (83.9%). At the study visit (mean follow-up 33.6 months, SD 15.9) 33 children (35.1%) had BCVA ≥ 6/18 in their best eye and 13 remained blind (13.8%). Spherical equivalent ≤ 2 D was present in 42.6% and astigmatism ≤ 2 D in 80.5% (n = 157). Functionally, vision was normal or nearly normal in 76 children (71.7%) and severe low vision and blindness remained in 2 children each (1.9%). Conclusion: Bilateral pediatric cataract surgery can offer good functional results, even if BCVA does not improve to the same extent. Orthoptic and low vision facilities with efficient community liaison are recommended.

Purpose: The purpose of the study is to compare the efficiency as well as the rate and type of suture-related complications between 10-0 monofilament nylon (Aurolab Nylon Sutures, double arm, Aurolab) and 10-0 polyglactin 910 sutures (Vicryl, single arm, Aurolab) for pediatric cataract surgery. Methods: It is a prospective, comparative study performed in children who underwent surgery for congenital or developmental cataract from March 2013 to February 2016. Patients underwent suturing with either nylon or Vicryl in unilateral cases, but in most bilateral surgeries, one eye received Vicryl sutures while the other eye received nylon. The sutures were compared for their complications and the need for suture removal. Results: Forty-one children (72 eyes) were included in the study, of which 31 children (62 eyes) underwent bilateral surgery while 10 (10 eyes) underwent unilateral surgery. Sixty-four nylon sutures were placed in 32 children (34 eyes), of which 22 (34.4%) were removed due to suture-related complications, whereas 14 (19.7%) (P = 0.03) of the 71 Vicryl sutures placed in 32 children (38 eyes) needed suture removal at an average of 2.9 weeks with the earliest at 6 days postoperatively. The odds of Vicryl suture being removed was 0.42 times with respect to nylon. The most common reason encountered for suture removal in both the materials was sutures becoming loose (16.3%), followed by vascularization (14.1%), infiltration (1.5%), and opacification (4.4%). Conclusion: Absorbable suture such as 10-0 Vicryl is preferred over nonabsorbable suture 10-0 nylon for suturing incisions in pediatric cataract surgery, to avoid subjecting the child to repeated anesthesia.

This study reports the short-term functional and anatomical outcome of Boston Type 1 keratoprosthesis (Boston Kpro) implantation for bilateral limbal stem cell deficiency (LCSD). Retrospective analysis was done on eight eyes of eight patients who underwent Boston Kpro implantation between July 2009 and October 2009. The best corrected visual acuity (BCVA) and slit-lamp biomicroscopy findings were assessed at 1, 3 and 6 months postoperatively. All eight eyes retained the prosthesis. BCVA of 20/40 or better was achieved in 8, 6, and 5 eyes at 1, 3, and 6 months, respectively, postoperatively. One patient each developed epithelial defect, sterile stromal melt and fungal keratitis in the late postoperative period associated with antecedent loss of the soft contact lens from the eye. Boston Kpro has good short-term visual and anatomical outcome in patients with bilateral LSCD, provided compliance with postoperative care can be ensured.

Dear Editor, We would like to congratulate Dr. Muralidhar and his colleagues for the study on a subject which is an established clinical practice at least in developing countries, but has never been well documented. Results of this study are of great value for ophthalmologists in developing countries like India where care and cost of care has to be finely balanced. In their non-randomized observational study, Muralidhar et al., found that the completion rate of anteriorcontinuouscurvilinear capsulorrhexis by trainee surgeons with the use of 2% hydroxypropylmethycellulose was 66.7% and overall completion rate with the help of a senior surgeon was 81.8%.[1] This is acceptable as compared to 90% completion rate with use of Healon in studies by Jeng et al.[2] Again, Hamada et al., reported a completion rate of anterior and posterior capsulorrhexis of 100% with use of Healon GV.[3] The completion rates of posterior capsulorrhexis reported by the authors in their study was 90%, which is fairly comparable. We feel that the authors have not factored in two variables which may change the outcomes in a similar study. These two factors are the age of the patient and the experience of the surgeon. Majority of the patients in their study group are 2 years or older except one patient. Only 1 child who is under 2 years had an extension of the anterior rhexis. Cataract surgery in younger children often is more challenging in view of higher positive vitreous pressure and shallower anterior chambers.[4] With the publication of Infant Aphakia Treatment Study results, more children younger than two years are likely to undergo primary intraocular lens (IOL) implantation.[5] We genuinely feel that this study could have been more valuable and complete had the authors included more children less than 2 years of age. We also feel that completion rates will be lower in younger children with use of low cost viscoelastics. We agree with the authors in their conclusion, that the completion rates are expected to be better for experienced surgeons. It would have been helpful if they had compared completion rates of experienced surgeon to that of trainees in age matched controls. In addition, the authors have not included cataracts with anterior segment anomalies like zonular weakness, fibrotic capsules, capsular plaques, persistent hyperplastic primary vitreous etc., in their study. Further studies are needed to assess completion rates with low cost viscoelastic in these admittedly difficult cases.

A critical step in phacoemulsification (as well as extracapsular cataract extraction) is making a window in anterior capsule wall (i.e. anterior capsulotomy). Continuous Curvilinear Capsulorhexis (CCC) has become recognized as the standard method of anterior capsulectomy. Techniques employed for CCC have undergone sustained evolution. The present review evaluates elementary principles of CCC. Management of CCC in the presence of small pupil and pseudoexfoliation syndrome is discussed. Main differences of pediatric CCC from its adult-style counterpart and finally several techniques of rescue of an extending capsulorhexis are also reviewed.

Scleral fixated intraocular lens (SFIOL) is a safe and effective option for managing optical aphakia. Suture related complications like suture erosion, suture breakage, endophthalmitis, etc. are unique to SFIOL. The knots can be covered by partial thickness flaps or they can be rotated into scleral tissues without flaps to reduce the complications. We performed a recently described novel technique which obviates the need for knot and scleral flaps in securing the SFIOL. This novel 2-point Ab externo knotless technique may reduce the knot related problems. Twenty-three eyes undergoing this knotless SFIOL procedure were analyzed for intraoperative and postoperative complications. Twenty-two eyes either maintained or improved on their preoperative vision. All patients had a minimum follow-up of 24 months.

Bilateral sixth nerve paresis following closed head injury, though rare, is a known entity. However, delayed-onset post-traumatic bilateral abducens paresis is extremely rare. We present two cases. The first patient had onset of bilateral abducens paresis 2 weeks after closed head injury and the second patient after 3 days. The cause in the former was detected to be chronic subdural hematoma and in the latter is speculated to be edema/ischemia due to injury to soft tissue structures housing these nerves. The delayed onset of bilateral abducens paresis following head injury may vary according to the cause. There may be another mechanism of injury apart from direct trauma. Though rare, it needs to be evaluated and may have a treatable cause like elevated intracranial pressure.