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82 results on '"Vertuani, Silvia"'

1. Highlight article: Effects of tocotrienol supplementation in Friedreich’s ataxia: A model of oxidative stress pathology

Author

Bolotta, Alessandra, Pini, Antonella, Abruzzo, Provvidenza M, Ghezzo, Alessandro, Modesti, Alessandra, Gamberi, Tania, Ferreri, Carla, Bugamelli, Francesca, Fortuna, Filippo, Vertuani, Silvia, Manfredini, Stefano, Zucchini, Cinzia, and Marini, Marina

Subjects
Friedreich’s ataxia, tocotrienol, oxidative stress markers, inflammation, lipidomics, hepcidin, inflammation, Ambientale, LS7_3, Friedreich’s ataxia, lipidomics, tocotrienol, hepcidin, oxidative stress markers
Published
2020

2. Hyaluronic Acid in the 3rd Millennium

Author

Fallacara, Arianna, Baldini, Erika, Manfredini, Stefano, and Vertuani, Silvia

Subjects
medicine_pharmacology_other
Abstract

Since its first isolation in 1934, hyaluronic acid (HA) has been studied across a variety of research areas. This unbranched glycosaminoglycan consisting of repeating disaccharide units of N-acetyl-D-glucosamine and D-glucuronic acid is almost ubiquitary in humans and in other vertebrates. HA is involved in many key processes -including cell signaling, wound reparation, tissue regeneration, morphogenesis, matrix organization and pathobiology-, and has unique physico-chemical properties -such as biocompatibility, biodegradability, mucoadhesivity, hygroscopicity and viscoelasticity. For these reasons, exogenous HA has been investigated as drug delivery system and treatment in cancer, ophthalmology, arthrology, pneumology, rhinology, urology, aesthetic medicine and cosmetic. To improve and customize its properties and applications, HA can be subjected to chemical modifications: conjugation and crosslinking. The present review gives an overview regarding HA, describing its history, physico-chemical, structural and hydrodynamic properties, and biology –occurrence, biosynthesis (by hyaluronan synthases), degradation (by hyaluronidases and oxidative stress), roles, mechanisms of action and receptors. Furthermore, both conventional and recently emerging methods developed for the industrial production of HA and its chemical derivatization are presented. Finally, the medical, pharmaceutical and cosmetic applications of HA and its derivatives are reviewed, reporting examples of HA-based products which currently are on the market or are undergoing further investigations.

Published
2018

3. Hibiscus sabdariffa L. una fonte sostenibile di antocianine. Caratterizzazione fitochimica e attività antiossidante di estratti dai calici

Author

Buso, Piergiacomo, Baldisserotto, Anna, Radice, Matteo, Alberto, Foschini, Chiara, Povolo, Alberto, Rumignani, Anna, Granello, Manfredini, Stefano, and Vertuani, Silvia

Subjects
Nutri-cosmesi, Attività antiossidante, Hibiscus sabdariffa L., Antocianidine, Attività antiossidante, Nutri-cosmesi, Fonti sostenibili, Hibiscus sabdariffa L, Antocianidine, Fonti sostenibili, NO
Published
2018

4. A multitarget approach toward the development of a novel series of 8-substituted purines for photoprotection and prevention of ultra violet (UV) related damages

Author

Djuidje, ERNESTINE NICAISE, Dissette, Valeria, Bino, Alessia, Benetti, Simonetta, Balzarini, Jan, Liekens, Sandra, Manfredini, Stefano, Vertuani, Silvia, and Baldisserotto, Anna

Subjects
UV-filtering, antioxidant activity, 8-substitutedpurines, benzimidazole, polyphenols, NO, antioxidant activity, benzimidazole, polyphenols, 8-substitutedpurines, UV-filtering
Published
2017

5. Composición química, actividad antioxidante y antimicrobiana del aceite esencial proveniente de la hojas de Piper pubinervulum C. DC Piperaceae

Author

Noriega, Paco F., Mosquera, Tatiana, Abad, Juan, Cabezas, Diana, Piedra, Sebastián, Coronel, Ivonne, Maldonado, María E., Bardiserotto, Anna, Vertuani, Silvia, and Manfredini, Stefano

Subjects
010405 organic chemistry, DPPH AND ABTS TEST, MIC, GC/EM, lcsh:S, 01 natural sciences, lcsh:S1-972, GC/MS, General Biochemistry, Genetics and Molecular Biology, 0104 chemical sciences, lcsh:Agriculture, 010404 medicinal & biomolecular chemistry, General Earth and Planetary Sciences, MIC BIOAUTOBIOGRAFÍA, BIOAUTOGRAPHY MIC, Actividad antioxidante, lcsh:Agriculture (General), General Agricultural and Biological Sciences, lcsh:Science (General), Piper pubinervulum, General Environmental Science, lcsh:Q1-390
Abstract

Piper pubinervulum C. DC., es una planta medicinal utilizada por los indígenas amazónicos del sur del Ecuador, las hojas poseen características aromáticas. El objetivo de la presente investigación es la de extraer y analizar las propiedades químicas y de actividad biológica del aceite esencial proveniente de las hojas.El estudio de composición química a través de GC-EM y RMN 1H arrojó la detección de 44 constituyentes dentro de los cuales b cariofileno, isoeugenol-metil éter, asarona y el nerolidol fueron los mayoritarios. La Actividad antioxidante del aceite fue evaluada por los métodos DPPH (1,1-diphenyl-2-picrylhydrazyl), ABTS (2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt) y la fotoquimioluminiscencia (PCL). Adicionalmente se realizaron estudios de actividad empleando (HP)TLC-DPPH bioautográficos. La actividad antimicrobiana fue evaluada por el método de difusión de disco en dos bacterias Gram+, dos bacterias Gram- y dos levaduras. Los resultados más interesantes se producen con las dos levaduras Candida tropicalis (MIC 0,77mg/ml) y Candida albicans (MIC0,33mg/ml) donde la actividad fue similar al aceite esencial de Thymus vulgaris el estándar natural de referencia. Los buenos resultados con respecto a la actividad antifúngica nos llevan a concluir que el aceite esencial podría ser usado con esta finalidad. // Piper puvinervulum C. DC. is a medicinal plant used by Amazon Indians in southern Ecuador, the leaves possess aromatic characteristics. The objective of this research is to extract and analyze the chemical properties and biological activity of the essential oil from the leaves. The study of the chemical composition based on analysis GC-MS and 1H RMN data resulted in the identification of 44 compounds including the main components: b-caryophyllene (1), isoeugenol methyl ether (2), asarona (3), and nerolidol (4). The antioxidant potential of the oils was assessed with the DPPH (1,1-diphenyl-2-picrylhydrazyl), ABTS (2,2’-Azinobis(3- ethylbenzothiazoline-6-sulfonic acid) diammonium salt), Photochemiluminescence and bioautographic HPTLC-DPPH methods. The antimicrobial activity was evaluated by means of disc diffusion method while the antimicrobial effect was evaluated in two Gram+ bacteria, two Gram- bacteria, and two yeasts. The essential oil was found effective against Candida tropicalis (MIC0,77 mg/ml) and Candida albicans (MIC0,33mg/ml) yeasts in a manner similar to the reference essential oil of Thymus vulgaris. The positive results in terms of antifungal activity suggest that the essential oil could be used for this purpose.

Published
2016

6. L’Acido Ialuronico (AI) nei trattamenti estetici, una review critica

Author

Manfredini, Stefano, Fallacara, Arianna, Giorgia De Carie, and Vertuani, Silvia

Subjects
viscoelasticità, dermal fillers, medicina estetica, Acido ialuronico, Ambientale, effetti collaterali, Acido ialuronico, cross-linking, dermal fillers, effetti collaterali, ialuronidasi, medicina estetica, viscoelasticità, ialuronidasi, cross-linking
Published
2016

8. Medicinal Composition

Author

Alessandra, di Stefano, Manfredini, Stefano, and Vertuani, Silvia

Subjects
Ambientale, Internazionale-PCT
Published
2014

22. Novel molecular combination deriving from natural aminoacids and polyphenols: Design, synthesis and free-radical scavenging activities

Author

Anna Baldisserotto, Emanuela Scalambra, Stefano Manfredini, Vertuani Silvia, Elisa Durini, and Gemma Malisardi

Subjects
Antioxidant, DPPH, medicine.medical_treatment, Dopamine, Context (language use), Antioxidants, chemistry.chemical_compound, Structure-Activity Relationship, Picrates, Drug Discovery, medicine, Organic chemistry, Humans, Phenols, Amino Acids, Pharmacology, Methionine, Molecular Structure, Organic Chemistry, Biphenyl Compounds, Polyphenols, General Medicine, Phenolic acid, Free Radical Scavengers, chemistry, Polyphenol, Drug Design, Indicators and Reagents, Reactive Oxygen Species, Cysteine
Abstract

Following the recent output of scientific publications in the matter of synergic activity between different antioxidants, we have undertaken the present study with the aim to synthesize new molecules with radical-scavengers activity based on the conjugation of bioactive portions (i.e. phenols, cysteine, methionine or tyrosine), characterized by different structures and mechanisms of action, to promote the simultaneous quenching of different radical species in the site of the oxidative damage. In this context, derivatives of phenolic acid, aminoacids and dopamine have been also prepared. The newly synthesized compounds were evaluated in vitro applying specific and complementary antioxidant test such as DPPH assay and ORAC test. As emerged from the evaluation, prerequisites for the activity of the synthesized molecules were: i) the maintenance of at least two hydroxylic groups on the aromatic moiety of phenolic portion, ii) the presence of a spacer between the aromatic moiety and the carbonilic group.

Published
2011

24. A novel Antioxidant derived from biotechnologically produced Verbascoside: activity and stability studies in dermo-cosmetic and pharmaceutical topical formulations

Author

Vertuani, Silvia, Beghelli, Erika, Scalambra, Emanuela, Malisardi, Gemma, Stefano, Copetti, Roberto, Daltoso, Baldisserotto, Anna, and Manfredini, Stefano

Subjects
meristematic cells, HPLC analysis, PCL, Verbascoside, VPP, antioxidant activity, stability in dermocosmetic formulation, suppositories, sustainability
Published
2011

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