1. Repeat controlled human malaria infection of healthy UK adults with blood-stage
- Author
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Jo, Salkeld, Yrene, Themistocleous, Jordan R, Barrett, Celia H, Mitton, Thomas A, Rawlinson, Ruth O, Payne, Mimi M, Hou, Baktash, Khozoee, Nick J, Edwards, Carolyn M, Nielsen, Diana Muñoz, Sandoval, Florian A, Bach, Wiebke, Nahrendorf, Raquel Lopez, Ramon, Megan, Baker, Fernando, Ramos-Lopez, Pedro M, Folegatti, Doris, Quinkert, Katherine J, Ellis, Ian D, Poulton, Alison M, Lawrie, Jee-Sun, Cho, Fay L, Nugent, Philip J, Spence, Sarah E, Silk, Simon J, Draper, and Angela M, Minassian
- Subjects
Adult ,Plasmodium falciparum ,Animals ,Humans ,Parasites ,Malaria, Falciparum ,United Kingdom ,Malaria - Abstract
In endemic settings it is known that natural malaria immunity is gradually acquired following repeated exposures. Here we sought to assess whether similar acquisition of blood-stage malaria immunity would occur following repeated parasite exposure by controlled human malaria infection (CHMI). We report the findings of repeat homologous blood-stageClinicalTrials.gov, identifier NCT03906474, NCT02927145.
- Published
- 2022