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A recent report from Des Moines University discusses the clinical and nonclinical uses of ketamine, highlighting its evolution from an anesthetic agent to a versatile treatment for various conditions, including pain management and psychiatric disorders. The research emphasizes ketamine's impact on patient care and its recognition as a drug of abuse due to its hallucinogenic and sedative effects. Financial support for the study was provided by IOER and the NIH National Institute on Alcohol Abuse & Alcoholism. The research has been peer-reviewed and offers valuable insights into the multifaceted nature of ketamine therapy. [Extracted from the article]

A recent study conducted at Des Moines University in Iowa aimed to identify the genes and cellular mechanisms that contribute to the development of depressive-like behaviors in individuals with chronic pain. The researchers analyzed the transcriptomic profile of the hippocampus, a brain region involved in mood regulation, in male rats exposed to chronic inflammatory pain. They found dysregulation of genes related to neuro-inflammation, cell cycle/neurogenesis, and blood-brain barrier integrity in animals that exhibited increased behavioral emotionality. These findings suggest a connection between dysregulation of hippocampal genes and the emotional symptoms often experienced by individuals with chronic pain. [Extracted from the article]

A recent study conducted by researchers at Des Moines University in Iowa explored the potential use of IL-29, a cytokine in the IFN lambda family, for immunotherapy of cervical cancer. The study found that IL-29 inhibited the growth of cervical cancer cells by reducing cell proliferation and promoting cell apoptosis. The researchers also observed increased expression of anti-proliferative and pro-apoptotic molecules in the presence of IL-29. These findings suggest that IL-29 may be a promising cytokine for the treatment of cervical cancer. The research has been peer-reviewed and published in Medical Oncology. [Extracted from the article]

A study conducted by Drake University explores the use of mineralocorticoid receptor antagonists (MRAs) in treating diabetic kidney disease (DKD). DKD is a global epidemic and a leading cause of end-stage kidney disease. The study focuses on the pharmacology of different generations of MRAs, such as spironolactone, eplerenone, and finerenone, and how they protect against DKD in patients with type 2 diabetes. The research concludes that finerenone, a non-steroidal MRA, shows promise in protecting against DKD. This study provides valuable insights into potential therapies for DKD. [Extracted from the article]

A study conducted at Drake University in Des Moines, Iowa, examined the inclusion of social identities in pharmacy education. The researchers reviewed 144 cases presented to student pharmacists over three semesters and found that social identities, such as race, gender, socioeconomic status, ability, sexual orientation, and nationality, were rarely explicitly stated in the cases. The study concluded that pharmacy education should assess how it currently acknowledges these identities in order to determine the next steps for integration. The research was published in the American Journal of Pharmaceutical Education. [Extracted from the article]

A recent study conducted by investigators from Des Moines University examined the prevalence and patterns of catastrophic spending for antidiabetic medication in the United States in 2020. The study found that medication costs for antidiabetic drugs have significantly increased, raising concerns about the affordability of these essential treatments. The research analyzed data from the 2020 Medical Expenditure Panel Survey and found that an estimated 10.3% of Americans with diabetes experienced out-of-pocket spending for antidiabetic drugs that reached catastrophic spending thresholds. The study concluded that the affordability of prescribed medication for individuals with diabetes remains a significant challenge for many Americans. [Extracted from the article]

A recent study conducted at Des Moines University in Iowa explores a holistic approach to treating prostate cancer. The researchers suggest that natural products, such as green tea and pomegranate, along with regular exercise, may enhance current treatment protocols and improve quality of life for patients. The study discusses the viability of these natural agents as treatments for prostate cancer and its complications. This research has been peer-reviewed and provides promising evidence for alternative treatment options. [Extracted from the article]

The action of cranberry against some cancer types has been reported, however, its role in lung cancer has only been investigated in large-cell lung cancer. Keywords: Des Moines; State:Iowa; United States; North and Central America; Adenocarcinoma; Cancer; Caspase; Enzymes and Coenzymes; Health and Medicine; Lung Cancer; Lung Diseases and Conditions; Lung Neoplasms; Oncology EN Des Moines State:Iowa United States North and Central America Adenocarcinoma Cancer Caspase Enzymes and Coenzymes Health and Medicine Lung Cancer Lung Diseases and Conditions Lung Neoplasms Oncology 1451 1451 1 11/06/23 20231107 NES 231107 2023 NOV 7 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Fresh data on Oncology - Lung Cancer are presented in a new report. Studies from Des Moines University Have Provided New Data on Lung Cancer (Say "no" To Cancer and ' Yes' To Cranberry: the Role of Cranberry Extract In Inhibition of Growth of Lung Adenocarcinoma Cells). [Extracted from the article]

Keywords: Des Moines; State:Iowa; United States; North and Central America; Cancer; Cell Proliferation; Gastroenterology; Health and Medicine; Oncology; Pancreas; Pancreatic Cancer; Pancreatic Neoplasms EN Des Moines State:Iowa United States North and Central America Cancer Cell Proliferation Gastroenterology Health and Medicine Oncology Pancreas Pancreatic Cancer Pancreatic Neoplasms 671 671 1 07/03/23 20230704 NES 230704 2023 JUL 4 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators discuss new findings in Oncology - Pancreatic Cancer. Our results showed that IL-28/RT enhanced RT-induced inhibition of cell proliferation and promoted apoptosis of MiaPaCa-2 cells. [Extracted from the article]

Keywords: Des Moines; State:Iowa; United States; North and Central America; Adenocarcinoma; Cancer; Drugs and Therapies; Gynecology; Health and Medicine; Immunotherapy; Oncology; Women's Health EN Des Moines State:Iowa United States North and Central America Adenocarcinoma Cancer Drugs and Therapies Gynecology Health and Medicine Immunotherapy Oncology Women's Health 491 491 1 06/26/23 20230627 NES 230627 2023 JUN 26 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Current study results on Oncology - Adenocarcinoma have been published. Advancements in immunotherapy now offer a new approach for various types of cancer and specifically show promise in the treatment of endometrial adenocarcinoma. [Extracted from the article]