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Purpose: The current study compares articaine 4% with lidocaine 2% in terms of injection pain and effectiveness of anesthesia when treating permanent mandibular first molars (PMFMs) affected by molar incisor hypomineralization (MIH). In addition to comparing the complications of local anesthesia for both solutions. Methods: The sample included 20 children. Each child was randomly assigned to either articaine 4% or lidocaine 2% in their first session with the other solution being used at the subsequent session. Injection pain and the effectiveness of anesthesia were assessed using the Wong-Baker Faces® Pain Rating Scale and the Face, Legs, Activity, Cry, and Consolability (FLACC) scale. Parents were asked to report any complications of local anesthesia. The Wilcoxon-matched pairs signed-rank test was used to analyze the data. Results: Patients experienced greater pain when receiving articaine 4% injections according to both scales, differences were statistically significant when using the Wong-Baker Faces® Pain Rating scale (p< 0.05). Whereas, the FLACC scale did not show such differences (P> 0.05). Although there were no significant differences between the two solutions regarding the effectiveness of local anesthesia according to both scales (P> 0.05), articaine 4% was clinically found to be more effective than lidocaine 2%. No complications of local anesthesia were reported. Conclusions: Articaine 4% injection was more painful than lidocaine 2%. However, both solutions were effective in anesthetizing PMFMs affected by MIH and without anesthetic complications in the studied sample. Trial registration: Clinical trial, NCT05200884, (https://clinicaltrials.gov/ct2/show/NCT05200884).

•CdS-PVA NCs films successfully deposited by CBD at different thiourea M concentration.•Polycrystalline cubic structure films, the roughness and RMS rise as TU M rises.•CdS-PVA NCs films of porous web structure and the pore size rise with TU M.•The absorption edge was blue shifted, the energy gap raise from (2.13 to 2.43) eV.•CdS-PVA NCs are good and novel, nitrogen dioxide gas sensors.

•CdS/PVA nanocomposites successfully deposited on glass substrates at different thiourea (TU) concentration (0.1, 0.15, and 0.2) M.•All nanocomposite films have polycrystalline structure in nature of cubic phase.•The films roughness and Root Mean Square were increased with the increase of TU concentrations.•CdS-PVA nanocomposite films tending to be porous and the pore size raise with the TU concentration.•The absorption edge was blue shifted and the energy gap raise from 2.13 eV to 2.43 eV for 0.1 and 0.2 TU concentration.

ObjectiveTo compare all licensed drug interventions as oral monotherapy for the acute treatment of migraine episodes in adults.DesignSystematic review and network meta-analysis.Data sourcesCochrane Central Register of Controlled Trials, Medline, Embase, ClinicalTrials.gov, EU Clinical Trials Register, WHO International Clinical Trials Registry Platform, as well as websites of regulatory agencies and pharmaceutical companies without language restrictions until 24 June 2023.MethodsScreening, data extraction, coding, and risk of bias assessment were performed independently and in duplicate. Random effects network meta-analyses were conducted for the primary analyses. The primary outcomes were the proportion of participants who were pain-free at two hours post-dose and the proportion of participants with sustained pain freedom from two to 24 hours post-dose, both without the use of rescue drugs. Certainty of the evidence was graded using the confidence in network meta-analysis (CINeMA) online tool. Vitruvian plots were used to summarise findings. An international panel of clinicians and people with lived experience of migraine co-designed the study and interpreted the findings.Eligibility criteria for selecting studiesDouble blind randomised trials of adults (≥18 years) with a diagnosis of migraine according to the International Classification of Headache Disorders.Results137 randomised controlled trials comprising 89 445 participants allocated to one of 17 active interventions or placebo were included. All active interventions showed superior efficacy compared with placebo for pain freedom at two hours (odds ratios from 1.73 (95% confidence interval (CI) 1.27 to 2.34) for naratriptan to 5.19 (4.25 to 6.33) for eletriptan), and most of them also for sustained pain freedom to 24 hours (odds ratios from 1.71 (1.07 to 2.74) for celecoxib to 7.58 (2.58 to 22.27) for ibuprofen). In head-to-head comparisons between active interventions, eletriptan was the most effective drug for pain freedom at two hours (odds ratios from 1.46 (1.18 to 1.81) to 3.01 (2.13 to 4.25)), followed by rizatriptan (1.59 (1.18 to 2.17) to 2.44 (1.75 to 3.45)), sumatriptan (1.35 (1.03 to 1.75) to 2.04 (1.49 to 2.86)), and zolmitriptan (1.47 (1.04 to 2.08) to 1.96 (1.39 to 2.86)). For sustained pain freedom, the most efficacious interventions were eletriptan and ibuprofen (odds ratios from 1.41 (1.02 to 1.93) to 4.82 (1.31 to 17.67)). Confidence in accordance with CINeMA ranged from high to very low. Sensitivity analyses on Food and Drug Administration licensed doses only, high versus low doses, risk of bias, and moderate to severe headache at baseline confirmed the main findings for both primary and secondary outcomes.ConclusionsOverall, eletriptan, rizatriptan, sumatriptan, and zolmitriptan had the best profiles and they were more efficacious than the recently marketed drugs lasmiditan, rimegepant, and ubrogepant. Although cost effectiveness analyses are warranted and careful consideration should be given to patients with a high risk cardiovascular profile, the most effective triptans should be considered as preferred acute treatment for migraine and included in the WHO List of Essential Medicines to promote global accessibility and uniform standards of care.Systematic review registrationOpen Science Framework https://osf.io/kq3ys/.

In order to develop the main applications of Cu-based shape memory alloys (SMAs), the effect of annealing time and temperature on the microstructure, mechanical properties, and shape memory characteristics of Cu-Al-Ni-xCo SMAs (xis 0.38, 0.6, and 1.2 wt.%) were studied. A distinct consideration is lent to the microstructural changes, phase transformation, and mechanical properties, which might take place in accordance with the changes in the alloying element/composition and/or heat treatment implementation. Because of this, the microstructural changes were portrayed using a variable-pressure scanning electron microscope, energy-dispersive spectrometer, and x-ray diffraction. The strength and hardness were determined using a universal Instron testing machine and Vickers hardness testing machine, respectively. The shape memory test was carried out using specially designed with an insulated system. The results indicated that the phase transformation of Cu-Al-Ni-xCo SMAs can be changed by varying the annealing temperature and time, and subsequent annealing can cause an effective impact on the shape memory effect. Moreover, it was also realized that the annealing treatment is involved in controlling the presence of γ2phase precipitate, thereby, improving the mechanical properties. The highest fracture stress and strain of 860.94 MPa and 9.43%, respectively, were determined in the Cu-Al-Ni-0.6 wt.% Co SMAs after being annealed at 500 °C for 3 h. In particular, the Cu-Al-Ni-1.2 wt.% Co SMAs obtained 84.08% recovery, which is the highest strain recovery after being annealed at 500 °C for 3 h.

Inferior vena cava (IVC) surgery is uncommon and has traditionally been performed through open surgical approaches. Renal cell carcinoma with IVC extension generally requires vena cavotomy and reconstruction. Open removal of malpositioned IVC filters (IVCF) is occasionally required after endovascular retrieval attempts have failed. As our experience with robotic surgery has advanced, we have applied this technology to surgery of the IVC. We reviewed our institution’s experience with robotic surgical procedures involving the IVC to determine its safety and efficacy.

Les modalités d’imagerie des tumeurs neuroendocrines ont évolué au cours des dernières années et de nouveaux radiopharmaceutiques à visée diagnostique et thérapeutique sont disponibles au Liban depuis plusieurs années. Après un rappel historique et de certaines caractéristiques cliniques de ces tumeurs, nous explicitons la place des différents traceurs disponibles et illustrons leur évolution par des scintigraphies, des tomographies par émissions positroniques couplées à la tomodensitométrie et d’actes de radiothérapie métabolique réalisés au sein de nos départements de médecine nucléaire.

Depuis son application dans l’évaluation et le suivi des cancers épidermoïdes de la tête et du cou, la TEP/TDM est devenue la modalité d’imagerie de choix pour cette catégorie fournissant des informations anatomiques et métaboliques à la fois. La 18F-FDG-TEP/TDM est utile dans l’identification d’un primitif non déjà connu, la délimitation de l’extension de la tumeur primitive, la détection d’une atteinte ganglionnaire régionale même avec des ganglions de petite taille, la détection d’une atteinte métastatique à distance et parfois dans la détection d’un second primitif synchrone. Elle assure un rôle primordial dans l’évaluation de la réponse au traitement, dans le suivi de la récurrence à long terme et récemment dans la planification de la radiothérapie.

La prévalence des tumeurs neuroendocrines (TNE) est rare. Malgré la présence de forme agressive, plusieurs TNE sont de croissance lente et leur diagnostic est très souvent porté tardivement à un stade métastatique avec plus de 50 % de métastases hépatiques. Le seul traitement curatif est la chirurgie radicale et les différents modes thérapeutiques non chirurgicaux utilisés chez ces patients sont la chimiothérapie, la chimio-embolisation hépatique, l’interféron alpha, les analogues froids ou non radioactifs de la somatostatine et, plus récemment introduite, la radiothérapie métabolique ou interne par un analogue de la somatostatine couplé à un radio-isotope adapté. Actuellement, l’utilisation du 68Ga-DOTATATE en TEP dans l’imagerie des TNE permet d’obtenir une meilleure qualité d’image et une bonne dosimétrie pré-thérapeutique par un analogue de la somatostatine couplé à un radio-isotope adapté tel que 177Lu-DOTATATE. Cette nouvelle modalité thérapeutique permet de stabiliser une maladie rapidement évolutive et améliorer suffisamment la qualité de vie en la modifiant profondément. Nous présentons notre expérience libanaise à propos de 6 cas traités par le 177Lu-DOTATATE après une TEP/TDM 68Ga-DOTATATE, avec une revue de la littérature.

Conservation tillage, besides being more economical, prevents soil erosion and has other beneficial effects on our environment, but few studies have been conducted on differential responses of different crops to conservation tillage. The main objective of this study was to examine the interaction of tillage with crop species. Rainfed field experiments in a strip‐plot design with four replicates were conducted in the semiarid, central Bekaa Valley of Lebanon for 2 yr. There were three tillage treatments: conventional (CT), minimum (MT), and no tillage (NT). Crops studied were barley (Hordeum vulgareL.), chickpea (Cicer arietinumL.), and safflower (Carthamus tinctoriusL.). The experiment was initiated in 2005–2006 on a field in which CT was practiced for years. In 2006–2007, the experiment was conducted on the exact site following the same 2005/2006 randomization. In each year, NT had similar weed density and dry weight m−2as CT, and mean weed infestation over years was lower in CT and NT than in MT. Year × tillage × crop interaction was significant for plant height in April, days to flowering/heading, seed yield, and harvest index. Tillage × crop interaction existed for seed and straw yields, harvest index, and plant height at maturity. Barley yielded poorer in NT than in CT, but similar yields were obtained in NT and CT for chickpea and safflower, suggesting that the tap root system of chickpea and safflower may be more adapted to NT than the fibrous root system of barley. Results of this study could be used to organize demonstration trials to help encouraging farmers to try practicing NT.

Since safflower (Carthamus tinctoriusL.) has slow early growth, effective early weed control is essential. The objective of this study was to investigate the effectiveness of various nonchemical and chemical practices for weed management in rain‐fed safflower. Field experiments were performed for three production years in the Bekaa Valley of Lebanon. Six weed management practices were tested: delayed sowing, delayed sowing with interrow cultivation, normal sowing with interrow cultivation, preemergence herbicide, hand weeding, and the normal sowing weedy check. Averaged over 1999–2000 and 2000–2001, weeds were absent with herbicide application and there were as few as <4 weed plants m−2in delayed sowing with interrow cultivation and hand weeding. Interrow cultivation under normal sowing, herbicide application, and hand weeding gave higher safflower seed and straw yields than the weedy check. Over the three production years, only interrow cultivation under normal sowing and hand weeding produced higher safflower seed and straw yields than the weedy check. In conclusion, interrow cultivation under normal sowing could be considered the best practice; application of pendimethalin and pronamide was also superior to delay sowing.

Finasteride has been used frequently in the treatment of prostate hyperplasia, but this drug inhibits 5α-reductase and for this reason could be useful for the treatment of hirsutism. The aim of this study was to evaluate the clinical and hormonal effects of finasteride on hirsute women with idiopathic hirsutism or polycystic ovary syndrome. Twenty-four women were randomly divided into two groups: those given placebo and those given finasteride 5 mg/day. The treatment period was 6 months. All patients were evaluated before the beginning of treatment (baseline) and after 3 and 6 months of treatment using clinical examination through Ferriman-Gallwey score, blood pressure, cardiac frequency and body mass index. Also, we collected blood for hormonal determination of levels of prolactin, 17α-hydroxyprogesterone, follicle stimulating hormone, luteinizing hormone, total and free testosterone, dehydroepiandrosterone sulfate, androstenedione and dihydrotestosterone. Furthermore, all patients were asked about their concerns and satisfaction with the treatment. The results showed that the Ferriman-Gallwey score in the 6th month of finasteride treatment was significantly lower than at baseline and the 3rd month of this drug treatment. The dihydrotestosterone level in the finasteride group was also significantly reduced compared to that in the placebo group. The other hormones did not show any statistical difference during the study. All the patients treated with finasteride perceived a reduction in hirsutism after 6 months. In conclusion, our data suggest that finasteride may be effective for the treatment of the hirsute woman with idiopathic hirsutism or polycystic ovary syndrome.

Objective: To compare the effects of continuous combined conjugated equine estrogens plus medroxyprogesterone acetate (CEE/MPA) with those of tibolone on symptom control, bleeding pattern, lipid profile and tolerability in postmenopausal women. Methods: This was a randomized, open-label, parallel-group, multicenter study. Generally healthy postmenopausal women with an intact uterus and no contraindications to hormone replacement therapy (HRT) or tibolone were enrolled. Each subject was randomly assigned to receive CEE/MPA 0.625 mg-5.0 mg or tibolone 2.5 mg daily for 13 treatment cycles, each of 28 days. Results: A total of 85 subjects were enrolled and received at least one dose of study medication, of which 76 (89.4%) subjects completed the study (n = 40, CEE/MPA; n = 36, tibolone). The incidence of postmenopausal symptoms decreased significantly over time in both treatment groups, compared with baseline, including significant decreases in the incidence of urogenital and sexual health symptoms. Significant differences in symptom control (other than hot flushes) were observed between treatment groups in a few different cycles for different symptoms, but no consistent or clinically significant trends were observed. No statistically significant differences in the incidence of bleeding were observed between treatment groups after cycle 4. Significant decreases in total cholesterol (5.6%) and low-density lipoprotein (LDL) cholesterol (7.5%) were observed at cycle 13, compared with baseline, in the CEE/MPA group, and significant decreases in high-density lipoprotein (HDL) cholesterol (8.5%) and triglycerides (13.7%) were observed at cycle 13, compared with baseline, in the tibolone group. Significant weight gain was observed at cycle 13 in the tibolone group (3.05 kg), compared with the CEE/MPA group (0.96 kg). The incidences of adverse events were similar in both treatment groups. Conclusions: Women treated with CEE/MPA or tibolone showed significant improvement of postmenopausal symptoms, including urogenital and sexual health symptoms, and had similar bleeding patterns after four cycles of therapy. CEE/MPA and tibolone each induced a different mix of changes in the lipid profile.

Tetralogy of Fallot with pulmonary atresia with major aorto pulmonary artery collaterals (TOF-PA MAPCAS) is a rare and complex cyanotic congenital heart malformation with a high incidence of early mortality and morbidity. Different surgical interventions have been described including construction of a systemic to pulmonary artery shunt (Modified Blalock-Taussig shunt or central shunt) and unifocalization, however the perioperative mortality remains significant due to the high incidence of thrombosis, obstruction, and pulmonary artery (PA) distortion. Another alternative is a palliative right ventricle to pulmonary artery connection (RVPAC) to bring antegrade flow to diminutive PAs. The objective of our study was to evaluate the impact of RVPAC on mortality, survival, morbidity, PA growth and eligibility for biventricular repair. We believe that the RVPAC approach allows for better PA growth and obviates the need for a conduit at the time of complete repair.

Irradiation of excised stem segments from de-etiolated seedlings of Cuscuta planiflorafor 24 h with mixtures of red and far-red light with red to far-red ratios between 0.02 to 1.0 enhanced coiling and formation of prehaustoria. Maximum number of prehaustoria were recorded when red:far-red was near 0.1. Coiling and prehaustoria were observed whenever estimated in vivoPfrPtotal at photoequilibrium was between 0.06 and 0.67. Irradiation of excised stem segments from white light grown seedlings with 12 h blue light also promoted coiling and prehaustoria formation after another 38 h in darkness. Coiling and prehaustoria were not observed in segments pulsed with 10 min red light at the end of 12 h in blue light. Coiling and prehaustoria were observed after photoreversible end-of-day far-redredfar-red pulses but not after redfar-redred pulses. A far-red pulse may not reverse inhibition by end-of-day red pulse when far-red is given more than 12 h after the red pulse.

Recent studies have shown that the canonical Shine-Dalgarno (SD)-anti-SD interaction is dispensable for the initiation of translation of certain mRNAs in Escherichia coli. Alternative non-SD sequences (located upstream from the initiation codon) and also downstream sequences (“downstream boxes”) complementary to 16S rRNA were found to be involved in the initiation of translation of mRNAs devoid of either SD or any leader sequences. In this study the chloramphenicol acetyltransferase (CAT) gene was modified to remove the 5' terminal non-translated region and/or the two potential downstream boxes in the CAT gene. Thus a series of ten CAT gene constructs was created and expressed in E. coliunder a strong constitutive promoter. The results showed that CAT mRNAs devoid of both leader sequence nucleotides and the two downstream boxes in the CAT gene remained active in vivoand produced CAT protein in sufficient amounts for survival of the transformed cells at chloramphenicol concentrations up to 20-30 μg/ml.

The human renin gene is expressed in the kidney, placenta, and several other sites. The release of renin or its precursor, prorenin, can be affected by several regulatory agents. In this study, primary cultures of human placental cells were used to examine the regulation of prorenin release and renin mRNA levels and of the transfected human renin promotor linked to chloramphenicol acetyltransferase reporter sequences. Treatment of the cultures with a calcium ionophore alone, calcium ionophore plus forskolin (that activates adenylate cyclase), or forskolin plus a phorbol ester increased prorenin release and renin mRNA levels 1.3- to 6-fold, but several classes of steroids did not affect prorenin secretion or renin RNA levels. The transfected renin promoter (584 or 100 base pairs of 5'-flanking DNA) initiated at the correct start site in these cells and forskolin increased its expression 2.5- to 4-fold. Constructs containing renin 5'-flanking DNA linked to a heterologous promoter cotransfected into HeLa cells with either glucocorticoid or estrogen receptor expression vectors were not regulated by dexamethasone or 17 beta-estradiol. These results suggest that (i) the first 584 base pairs of the renin gene 5'-flanking DNA do not contain functional glucocorticoid or estrogen response elements, (ii) placental prorenin release and renin mRNA are regulated by calcium ion and by the combinations of cAMP with either C kinase or calcium ion, and (iii) the first 100 base pairs of the human renin 5'-flanking DNA direct accurate initiation of transcription and can be regulated by cAMP. Thus, some control of renin release in the placenta (and by inference in other tissues) occurs via transcriptional influences on its promoter.

Here, we confirm and extend our previous findings on human immunodeficiency virus type 1 (HIV-1) envelope glycoproteinN-acetylglucosaminyl binding properties. We show the occurrence of saturable, temperature, pH, and calcium dependent carbohydrate-specific interactions between recombinant precursor gp160 (rgp160) and two affinity matrices:d-mannose-divinylsulfone-agarose, and natural glycoprotein, fetuin, also coupled to agarose. Binding of rgp160 to the matrices was inhibited by soluble mannosyl derivatives, α-d-Man17-BSA and mannan, by β-d-GlcNAc47-BSA and by glycopeptides from Pronase-treated porcine thyroglobulin, which produces oligomannose and complex N-linked glycans. Glycopeptides from Endoglycosidase H-treated thyroglobulin partially inhibited rgp160 binding, as did the asialo-agalacto-tetraantennary precursor oligosaccharide of human α1-acid glycoprotein for binding to fetuin-agarose. β-d-Glucan and β-d-Gal17-BSA had no or only limited effect. Also, surface unit rgp120 specifically interacted with fetuin-agarose and soluble fetuin, but in the latter case with a twofold reduced affinity relative to rgp160. After affinity chromatography, rgp160 was specifically retained by the two matrices and eluted by mannan in both cases, while rgp120 was not retained by fetuin-agarose but only eluted as a significantly retarded peak, which confirms its specific but weak interaction. Thus, rgp160 interacts with both oligomannose type, and the mannosyl core of complex type N-linked glycans, and its gp120 region plays a role in this interaction. Because fetuin and asialofetuin inhibit to nearly the same extent, the binding of rgp160 or rgp120 to fetuin-agarose, interaction with sialic acid or β-d-galactosyl structures of complex N- or O-linked glycans can be ruled out. Specific rgp160 and rgp120 binding to ap-aminophenyl-β-d-GlcNAc-agarose matrix, which was inhibited by β-d-GlcNAc47-BSA and by fetuin, confirms that HIV-1 envelope glycoproteins can also specifically interact with theN-acetylglucosaminyl core of oligosaccharide structures.

Phytohormones were screened for their effects on induction of coiling and prehaustoria in de-etiolated excised dodder seedlings under different light treatments. Zeatin stimulated coiling and the formation of prehaustoria under all light tested, even in darkness. A synergistic effect was observed with zeatin and far-red light (700-800 nm) but not with red light (600-700 nm) on the formation of prehaustoria. Application of indole-3acetic acid inhibited zeatin-induced coiling and prehaustoria development under blue (400-500 nm) and a mixture of red plus far-red light, but not in blue plus far-red light. Ethylene had no effect on coiling and prehaustoria development. Observations suggest that zeatin-induced coiling and prehaustoria development may be mediated by phytochrome.

Studies on the thyroid-hormone receptors in the nuclei of developing chick brain revealed a single class of binding sites for tri-iodothyronine (T3) and thyroxine (T4) at all embryonic and adult ages. High-affinity [Ka = (1.85-3.3) X 10(9)M-1 and (0.3-0.6 × 10(9)M-1 for T3 and T4 respectively] receptors were detected in the brain as early as day 7 of embryonic development; their level increased progressively rapidly until day 13, and thereafter the value remained essentially constant during development. Occupancy of the receptor site with endogenous hormone was 75-90% at 7-11 days, 50-60% during the late phase of embryogenesis (13-17 days), and 80% after hatching. Comparison of the binding properties of the receptors with T3 and T4 indicates that, although the binding capacities per nucleus are almost identical, T4 has four to five times less binding affinity than T3. The half-lives of dissociation of solubilized T3- receptor complexes were 20-30h between 0 degrees and 7 degrees C, about 4h at 20 degrees C and less than 15 min at 37 degrees C. Studies of the regional distribution of receptors in the brain indicate that cerebrum has the highest concentration of T3 receptors (4000-7000 sites per nucleus); this concentration is 2-4-fold higher than that in the cerebellum, optic lobe or medulla oblongata. The overall results indicate that between 7 and 13 days of embryonic development the thyroid-hormone receptors in the embryonic chick brain, particularly in the cerebrum, assume a very high level and appear to be mostly saturated with endogenous hormone. This, and the temporal correspondence of the phenomenon with the period of neuronal growth and synaptogenesis, strongly indicate the influence of the hormone in the maturation of the developing brain.

Renin is formed by intracellular processing of prorenin and catalyzes the conversion of angiotensinogen to angiotensin I, the precursor to angiotensin II. Several tissues synthesize prorenin. However, in man, the kidney is the only known source of circulating renin, raising the possibility that the processing enzyme is unique to that tissue. We have transfected a gene that directs prorenin synthesis in pituitary AtT-20 cells, which are capable of processing other prohormones. The results demonstrate that transfected AtT-20 cells can secrete inactive prorenin, accurately process prorenin to active renin, and be stimulated to release active renin in response to a secretagogue. These data imply that cellular elements capable of directing the processing of prorenin to renin and its correct subcellular compartmentalization may be present in nonrenal cell types and that critical elements of the regulated release of renin that occur in the kidney can be reconstituted in cells in culture.

Two cis-acting elements in the p120 gene play important roles in transcription; the region from -537 to -278 is necessary for initiation of transcription, and the region from -1426 to -1223 is necessary for efficient transcription. The distal element(s) which lies upstream of -278 is required for initiation of transcription.

L’antigène membranaire spécifique de la prostate (PSMA) est exprimé́ 1000 fois plus au sein des tissus tumoraux que dans les cellules prostatiques normales. L’introduction du TEP 68Ga-PSMA a ainsi permis une meilleure détection des récidives locales et métastases tumorales après un traitement local initial en comparaison au TEP choline. Peu d’études ont évalué son rôle dans la détection de tumeur intra-prostatique.

In the past few years, the usage of Unmanned Aerial Vehicles (UAVs) aircraft has increased significantly, but the need for UAVs with higher performance is increasing also. Therefore, all systems of the UAVs must be developed to have high efficiency, including the propulsion system. It is necessary to perform some design and analysis tasks on low Reynolds number propeller, which is a commonly used propulsion system on UAVs, to have higher efficiency and improve the overall UAVs performance. In this paper, low Reynolds number propellers are designed using the Larrabee Design analytical method by referring to the "Master AirScrew 10x7E" propeller. Meanwhile, performance of the designed propellers is analysed by using analytical method of Inversing Larrabee Design method. At the design stage of low Reynolds number propeller, 42 variations of alpha design (ades ) was inputted along the blades with uniform, linear, and quadratic distributions. Furthermore, the best design from these 42 variations was selected by performing two-stage scoring. At first stage scoring, 42 designs are selected to obtain 5 designs with the highest on-design efficiency. Then, performance of these 5 selected designs are analysed analytically along a certain range of advance ratio. Finally, second stage scoring is performed to obtain 1 design with the best overall performance.

Abnormal pore pressure can cause some problems during the drilling process such as a blowout or sticking pipe while drilling. Pore pressure prediction may prevent the drilling hazard, especially in carbonate field that known as a complex reservoir. It is useful for mud weight determination to prevent blowout and sticking pipe while drilling. This study focuses on predicting pore pressure values and maps it through 3D seismic data. The field is carbonate reservoir which known as a heterogeneous formation with shale above the reservoir. Due to the difference of lithologies, the two different empirical parameter is used in each lithology for Eaton equation. The pore pressure prediction then correlates with the seismic attribute using a neural network method. The input parameter of the Eaton is sonic and density log. Then, the result of Eaton's method is calibrated by leak-off test (LOT) and repeat formation test (RFT), hence the results are more accurate and verified. Then, the pore pressure is correlated to acoustic impedance, shear impedance, seismic frequency, and seismic amplitude to create a subsurface model by the neural network machine learning. The result shows that the pore pressure prediction of the model is verified by the measured pore pressure well-log data with good accuracy up to 90%. The combination method of Eaton and neural network was proven to be able to predict and map pore pressure distribution in a complex carbonate field.

Abnormal pore pressure can cause some problems during the drilling process such as a blowout or sticking pipe while drilling. Pore pressure prediction may prevent the drilling hazard, especially in carbonate field that known as a complex reservoir. It is useful for mud weight determination to prevent blowout and sticking pipe while drilling. This study focuses on predicting pore pressure values and maps it through 3D seismic data. The field is carbonate reservoir which known as a heterogeneous formation with shale above the reservoir. Due to the difference of lithologies, the two different empirical parameter is used in each lithology for Eaton equation. The pore pressure prediction then correlates with the seismic attribute using a neural network method. The input parameter of the Eaton is sonic and density log. Then, the result of Eaton's method is calibrated by leak-off test (LOT) and repeat formation test (RFT), hence the results are more accurate and verified. Then, the pore pressure is correlated to acoustic impedance, shear impedance, seismic frequency, and seismic amplitude to create a subsurface model by the neural network machine learning. The result shows that the pore pressure prediction of the model is verified by the measured pore pressure well-log data with good accuracy up to 90%. The combination method of Eaton and neural network was proven to be able to predict and map pore pressure distribution in a complex carbonate field.

Chez les patients atteints de cancer prostatique (CP), les métastases cérébrales (MC) sont rares et ne se produisent qu’à des stades très avancés du néoplasme. Ainsi, la rareté des cas rapportés dans la littérature concernant les MC des CP détectées par la TEP/TDM au 18F-Choline (TEP FC) n’est pas relative à un manque de sensibilité de la méthode. Cependant, la 18F-Choline est un traceur qui n’est pas assez spécifique et des tumeurs bénignes ou malignes, autres que les MC des CP, peuvent le capter. Le but de notre étude est de clarifier la signification de l’hyperactivité focale anormale au niveau du cerveau, révélée chez les patients atteints de CP bénéficiant de TEP FC dans leur bilan d’extension.

L’histiocytose sinusale avec une lymphadénopathie massive ou maladie de Rosai-Dorfman (MRD) est un syndrome lympho-prolifératif bénin rare. La présentation clinique la plus fréquente correspond à des adénopathies cervicales bilatérales, indolores et massives avec de la fièvre, des sueurs nocturnes et une perte de poids. Bien que la manifestation cutanée de la MRD soit la forme la plus fréquente des atteintes extra-ganglionnaires, la forme purement cutanée, sans autres atteintes extra-ganglionnaires ou ganglionnaires, est assez rare. La MRD est souvent multifocale, et la découverte d’un foyer devrait faire suspecter d’autres foyers ganglionnaires ou bien extra-ganglionnaires. Nous rapportons le cas d’une TEP/TDM au 18FDG (TEP) effectuée dans le cadre du bilan d’une forme cutanée de MRD.