14 results on '"Lin, Xiaozhen"'
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2. Three-Dimensional Printed Titanium Prosthesis for Mandibular Condyle Reconstruction After Extensive Resection of Chondrosarcoma: A 6-year Follow-Up
- Author
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Han, Xiaodong, Song, Baixuan, Chen, Yuheng, and Lin, Xiaozhen
- Abstract
Chondrosarcomas (CHS) are malignant mesenchymal tumors arising from cartilage. Chondrosarcomas arising in the temporomandibular joint are especially rare. Herein, the authors report an unusual case of a 50-year-old female who presented with a progressive swelling in the left preauricular region. Computed tomography and magnetic resonance imaging revealed an osteolytic and expansive lesion in the left condyle. The diagnosis tended to be a malignant tumor. A resection guide and 3-dimensional printed titanium prosthesis for condyle reconstruction were designed. Extended resection of the left condyle and reconstruction were performed. The pathologic diagnosis was consistent with CHS (grade II). There was no tumor recurrence or distant metastasis at the 6-year follow-up, and good occlusion and satisfactory function of the temporomandibular joint were regained.
- Published
- 2023
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3. Squamous Cell Carcinoma Arising From Odontogenic Cyst Epithelium or Oral Mucosa Epithelium After Marsupialization of Odontogenic Radicular Cyst in Posterior Mandible?
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Han, Xiaodong, Shao, Xiaojun, Lin, Xiaozhen, Du, Zhaojie, and Wang, Yanyi
- Abstract
Squamous cell carcinomas (SCCs) are common malignant tumors in the oral and maxillofacial region. However, SCCs secondary to marsupialization of odontogenic radicular cysts are extremely rare. The authors report an unusual case of a 43-year-old male presented with dull pain in the right molar region of the mandible without numbness of lower lips, who had a long history of smoking, alcohol consumption, and betel nut chewing. Computerized tomography revealed a round well-defined unilocular radiolucent at the apex of lower right premolars, 2 nonvital teeth. The clinical diagnosis was the radicular cyst of the right mandible. The patient was initially treated with root canal therapy of the teeth followed by marsupialization with a mandibular vestibular groove incision. While the patient did not follow the instruction of irrigation of the cyst and had no regular follow-up. The reexamination of computerized tomography indicated a round well-defined unilocular radiolucent at the apex of lower right premolars and filled with a soft tissue without clear boundary with buccal muscles at 31 months follow-up. There were no masses or ulcer around the mandibular vestibular groove incision and the patient had no sign of numbness of lower lips. The clinical diagnosis was the radicular cyst of right mandible with infection. A curettage was performed. However, the pathologic diagnosis was well-differentiated SCC. An extended radical surgical resection including segmental resection of the right mandible was performed. The histopathology was well-differentiated SCC without the cyst epithelium and invasion of bone, which can be distinguished from primary intraosseous SCC. The case indicates that marsupialization performed in patients with a history of smoking, alcohol consumption, and betel nut chewing, has a risk of suffering from oral SCC.
- Published
- 2023
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4. Bone transport induces the release of factors with multi-tissue regenerative potential for diabetic wound healing in rats and patients
- Author
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Xie, Jing, Liu, Xuhua, Wu, Biaoliang, Chen, Bochong, Song, Qiancheng, Guan, Yuan, Gong, Yuanxun, Yang, Chengliang, Lin, Jinbo, Huang, Mingfeng, Tan, Xinyu, Lai, Ruijun, Lin, Xiaozhen, Zhang, Sheng, Xie, Xiaoling, Chen, Xiaoli, Zhang, Chunyuan, Yang, Mei, Nong, Huijiao, Zhao, Xiaoyang, Xia, Laixin, Zhou, Weijie, Xiao, Guozhi, Jiang, Qing, Zou, Weiguo, Chen, Di, Lu, Di, Liu, Jia, and Bai, Xiaochun
- Abstract
Tibial cortex transverse distraction is a surgical method for treating severe diabetic foot ulcers (DFUs), but the underlying mechanism is unclear. We show that antioxidant proteins and small extracellular vesicles (sEVs) with multiple-tissue regenerative potential are released during bone transport (BT) in humans and rats. These vesicles accumulate in diabetic wounds and are enriched with microRNAs (miRNAs) (e.g., miR-494-3p) that have high regenerative activities that improve the circulation of ischemic lower limbs while also promoting neovascularization, fibroblast migration, and nerve fiber regeneration. Deletion of miR-494-3p in rats reduces the beneficial effects of BT on diabetic wounds, while hydrogels containing miR-494-3p and reduced glutathione (GSH) effectively repair them. Importantly, the ginsenoside Rg1 can upregulate miR-494-3p, and a randomized controlled trial verifies that the regimen of oral Rg1 and GSH accelerates wound healing in refractory DFU patients. These findings identify potential functional factors for tissue regeneration and suggest a potential therapy for DFUs.
- Published
- 2024
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5. Correlation study of increase of pharyngeal airway space after mandibular advancement, taking natural head position into consideration.
- Author
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Lin, Xiaozhen
- Subjects
PEARSON correlation (Statistics) ,SPACE ,SQUARE root - Abstract
The increase in the pharyngeal airway space after mandibular advancement has not been well explained, and in this study we aimed to show whether there is a correlation in the increase of pharyngeal airway space as a consequence of the mandibular advancement or of the relative change between the mandibular position and the natural head position (NHP). Fifteen patients who had bilateral sagittal split osteotomy for mandibular advancement with or without genioplasty were studied retrospectively. The primary variables of mandibular position, NHP, and pharyngeal airway space were measured in three dimensions using preoperative and postoperative cone-beam computed tomographic datasets and were compared using the paired t test. The secondary variable of pharyngeal airway space was defined as the square root of the mean cross-sectional area (CSA
1/2 ) of the pharyngeal airway space. Pearson's correlation coefficient was used to find out whether there was a correlation between the change in CSA1/2 and the change in mandibular position, or the relative change between the mandibular position and the NHP. Volumes and minimal cross-sectional areas were increased in the pharyngeal airway space, and lengths of airways decreased. Correlation existed only between the increase in CSA1/2 and the relative change between the mandibular position and NHP. The increase in pharyngeal airway space after mandibular advancement correlated with the relative changes between the mandibular position and the NHP. [ABSTRACT FROM AUTHOR]- Published
- 2019
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6. Paramedian Lateral-angled Mandibulotomy for Resection of Squamous Cell Carcinoma in the Oral Cavity
- Author
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Han, Xiaodong, Shao, Xiaojun, and Lin, Xiaozhen
- Abstract
Mandibulotomy provides good access for monobloc compartmental resection of squamous cell carcinoma in the proper oral cavity. Various designs of osteotomy have been reported, but few of them have considered the local anatomical conditions, and thus related complications occasionally happen. We devised a paramedian lateral-angled mandibulotomy to reduce the side injuries.
- Published
- 2023
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7. A two-stage planning method for design and dispatch of distributed energy networks considering multiple energy trading.
- Author
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Ren, Fukang, Lin, Xiaozhen, Ma, Xiaotian, Wei, Ziqing, Wang, Ruzhu, and Zhai, Xiaoqiang
- Subjects
CARBON emissions ,MICROGRIDS ,GEOTHERMAL resources ,ECONOMIC indicators ,NATURAL gas processing plants ,ENERGY industries ,PRICES ,CARBON dioxide lasers - Abstract
• A two-stage optimization model is constructed to plan the distributed energy network. • Considering the energy adjustment mechanism, two scheduling strategies are proposed. • Various energy sources can be traded to enhance comprehensive performance. Distributed energy network integrated by distributed energy system has significant performance advantages due to energy sources sharing. However, the incorporation of multiple distributed energy systems also complicates design and operation. This study constructs a two-stage optimization framework to plan the distributed energy network, which is driven by solar energy, geothermal energy and natural gas. First, the scale and operation status of energy equipment are optimized based on the economic, energy and environment performance of the energy network, and then the energy trading prices are optimized to enhance the economic performance of the energy system. In addition, two scheduling modes are constructed according to the dispatching strategy of storage unit and transfer unit. Finally, NSGA-II+ARSBX and TOPSIS are utilized to determine the optimal solution. The case analysis indicates that the best dispatching strategy is to first consider energy transfer units, and the annual cost, primary energy and carbon dioxide emissions are reduced by 1.30%, 10.82% and 14.56%. As for energy exchange, multiple energy sources are traded at very low prices or free from 10 pm and 6 am, while those are traded at relatively high prices between 6 am and 10 pm. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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8. Predictable and Unpredictable Components of the Summer East Asia–Pacific Teleconnection Pattern
- Author
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Lin, Xiaozhen, Li, Chaofan, Lu, Riyu, and Scaife, Adam
- Abstract
The East Asia–Pacific (EAP) teleconnection pattern is the dominant mode of circulation variability during boreal summer over the western North Pacific and East Asia, extending from the tropics to high latitudes. However, much of this pattern is absent in multi-model ensemble mean forecasts, characterized by very weak circulation anomalies in the mid and high latitudes. This study focuses on the absence of the EAP pattern in the extratropics, using state-of-the-art coupled seasonal forecast systems. The results indicate that the extratropical circulation is much less predictable, and lies in the large spread among different ensemble members, implying a large contribution from atmospheric internal variability. However, the tropical–mid-latitude teleconnections are also relatively weaker in models than observations, which also contributes to the failure of prediction of the extratropical circulation. Further results indicate that the extratropical EAP pattern varies closely with the anomalous surface temperatures in eastern Russia, which also show low predictability. This unpredictable circulation–surface temperature connection associated with the EAP pattern can also modulate the East Asian rainband. 东亚-太平洋遥相关型(EAP型)是西北太平洋-东亚地区夏季环流变化的主要模态, 其结构范围从热带延伸至中高纬度地区. 然而, 在多模式集合平均预报中, EAP型没有出现, 其中高纬度地区环流异常非常弱. 本文利用现阶段较先进的季度预测系统, 分析了预测系统无法预测出EAP型热带外分量的原因. 结果表明, EAP型的热带外环流可预测性较低, 主要由于模式不同积分成员之间存在非常大的离散度, 受大气内部变率的影响. 另一方面, 模式所预测的EAP型的经向联系相对于观测较弱, 这也导致了模式无法预测出该遥相关型的热带外分量. 进一步的研究发现, EAP型的热带外分量与俄罗斯东部地区表面温度异常的变化紧密联系, 后者的可预测性也较低. 与EAP型相联系的这种环流-表面温度的不可预测性也将调制东亚降水雨带的变化.
- Published
- 2018
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9. Changes in natural head position in response to mandibular advancement.
- Author
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Lin, Xiaozhen and Edwards, Sean P.
- Subjects
MANDIBULAR joint ,ORTHOGNATHIC surgery ,OSTEOTOMY ,GENIOPLASTY ,ANALYSIS of variance - Abstract
We investigated the change in the natural head position and its relation to the change in the mandibular position in patients with mandibular hypoplasia. Forty-one patients treated by orthognathic surgery were divided into three groups: bilateral sagittal split osteotomy (BSSO) advancement (n = 8); BSSO advancement with genioplasty (n = 12), and Le Fort I osteotomy with BSSO advancement (n = 21). Cone-beam computed tomographic (CT) datasets were collected preoperatively and six weeks postoperatively. The natural head position was measured using the craniocervical angle and the distance from the second vertebra to the frontal plane, and the mandibular position was measured using the craniomandibular angle and the distance from the mandible to the frontal plane. Repeated measures two way ANOVA was used to assess the significance of differences between the angular and linear measurements, and Pearson’s correlation coefficient to assess those between the change in the mandibular position and the natural head position. The craniomandibular angle increased and the mandible to frontal plane distance decreased, as planned; the craniocervical angle increased, and the distance from the second vertebra to the frontal plane decreased in all three groups. ANOVA showed a significant difference in the time factor (preoperative compared with postoperative) but no significant differences between the groups or interaction (time multiplied by group) factors. There was a significant correlation between the change in mandibular position and the change in the natural head position. Changes in the natural head position after correction of mandibular hypoplasia are correlated with the change in the mandibular position, regardless of whether a genioplasty or Le Fort I osteotomy was done. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
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10. Accuracy of maxillary repositioning by computer-aided orthognathic surgery in patients with normal temporomandibular joints.
- Author
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Lin, Xiaozhen, Li, Biao, Wang, Xudong, and Shen, Steve G.F.
- Subjects
HYPERPLASIA treatment ,ORTHOGNATHIC surgery ,TEMPOROMANDIBULAR joint ,COMPUTER-aided design ,POSTOPERATIVE care - Abstract
Our aim was to assess the accuracy of computer-aided orthognathic surgery for maxillary repositioning in 15 patients with mandibular hyperplasia and normal temporomandibular joints (TMJ). We aligned preoperative and postoperative virtual skulls at the cranium using surface superimposition then recorded and calibrated three 3-dimensional coordinates (maxillary dental landmarks U0, 6R, and 6L) on the skulls. Errors between these preoperative and postoperative landmarks were calculated and the largest error of every patient was chosen for assessment. Landmark errors ranged from 1.00 – 2.49 mm, and recording errors from −0.06 – 0.07 mm. The superimposition error was mean (SD) 0.036 (0.002) mm. The accuracy of the method is acceptable in patients with a normal TMJ. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
11. Computer-Aided Freehand Maxillary Repositioning
- Author
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Lin, Xiaozhen, Sun, Yi, Han, Xiaodong, Wang, Jing, Zhang, Ming, and Liang, Limin
- Published
- 2018
- Full Text
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12. Use of a new curvilinear distractor to repair mandibular defects in dogs.
- Author
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Shang, Hongtao, Lin, Xiaozhen, Du, Jinghua, He, Lisheng, and Liu, Yanpu
- Subjects
TEMPOROMANDIBULAR joint ,OSTEOTOMY ,BONE growth ,MEDICAL radiography ,MANDIBLE ,LABORATORY dogs - Abstract
Abstract: We have investigated the feasibility of using a new curvilinear distractor to repair mandibular defects in 6 mature male dogs. A mandibular defect was created by an oblique osteotomy between the distal planes of the bilateral second premolars, and a transport disc 10mm wide was made. After a 7-day latency period, distraction was activated at 0.5mm/12h and consolidation lasted for 6 or 12 weeks. Three dogs were killed after 6 and 12 weeks’ consolidation for gross, radiographic, and histological observations to be made. Curvilinear distraction osteogenesis was successful in 5/6 animals. At both time points smooth curved bone had been restored in the distracted areas, and radiographic and histological examination showed that the generated bone was similar to normal bone after 12 weeks’ consolidation. These results suggest that the curvilinear distractor could complete curvilinear distraction osteogenesis in dogs’ mandibles. [Copyright &y& Elsevier]
- Published
- 2012
- Full Text
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13. Effect of mandibular advancement on the natural position of the head: a preliminary study of 3-dimensional cephalometric analysis.
- Author
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Lin, Xiaozhen, Liu, Yanpu, and Edwards, Sean P.
- Subjects
CEPHALOMETRY ,OSTEOTOMY ,COMPUTED tomography ,CRANIOMANDIBULAR disorders ,MANDIBLE ,CERVICAL vertebrae ,CONE beam computed tomography - Abstract
Abstract: Our aim was to investigate the potential effect of advancement by bilateral sagittal split osteotomy (BSSO) on the natural position of the head by using 3-dimensional cephalomentric analysis. Seven consecutive patients who had had only BSSO advancement, and had had preoperative and 6-week postoperative cone beam computed tomography (CT) scans, were recruited to this retrospective study. Two variables, SNB and SNC2, were used to indicate the craniomandibular alignment and craniocervical inclination, respectively, in the midsagittal plane. Using 3-dimensional cephalometric analysis software, the SNB and the SNC2 were recorded in volume and measured in the midsagittal plane at 3 independent time-points. The reliability was measured and a paired t test used to assess the significance of differences between the means of SNB and SNC2 before and after operation. The 3-dimensional cephalometric measurement showed good reliability. The SNB was increased as planned in all the mandibles that were advanced, the cervical vertebrae were brought forward after BSSO, and the SNC2 was significantly increased in 6 of the 7 patients. Three-dimensional cephalometric analysis may provide an alternative way of assessing cephalometrics. After BSSO advancement, the natural position of the head changed by increasing the craniocervical inclination in an anteroposterior direction. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
14. Use of an internal bidirectional distractor to elongate goats’ mandibles.
- Author
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Lin, Xiaozhen, Zhou, Libin, Shang, Hongtao, Liu, Yanpu, and Bo, Bin
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MANDIBLE ,GOATS as laboratory animals ,OSTEOTOMY ,RADIOGRAPHY ,HISTOLOGICAL techniques ,BONE growth ,ANATOMY - Abstract
Abstract: We investigated the feasibility of using an internal bidirectional mandibular distractor to elongate the mandibular bodies and rami of 4 mature male goats. An osteotomy was made at the right mandibular angle and the distractor placed within the osteotomy and allowed to heal in place for 5 days. The mandibles were simultaneously distracted vertically and horizontally at a rate of 0.5mm/day for 30 days. After a 12-week consolidation period, all the goats were killed for gross, radiographic, and histological evaluation. Smooth new bone had been restored in the distracted area after 12 weeks’ consolidation, and the gross, radiographic, and histological evaluations showed that the new bone was similar to the native bone. These results suggest that the internal bidirectional distractor could permit bidirectional distraction osteogenesis in a goat model. [Copyright &y& Elsevier]
- Published
- 2012
- Full Text
- View/download PDF
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