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17 results on '"Tanzilli G"'

1. Dual vs. triple antithrombotic treatment after percutaneous coronary intervention in patients with non-valvular atrial fibrillation: a meta-analysis on current evidence.

Author

ACCONCIA, M. C., CARETTA, Q., CHIAROTTI, F., TANZILLI, G., TORROMEO, C., PANNARALE, G., and GAUDIO, C.

Abstract

OBJECTIVE: Combination and duration of antithrombotic therapy in order to prevent both stent thrombosis and thromboembolic complications after coronary artery stenting (PCI) in non-valvular atrial fibrillation (AF) is still debated. This uncertainty can be attributed mainly to the fact that the reference trials were open-label and not adequately powered in order to reach a definitive conclusion on ischemic endpoints (i.e., stent thrombosis). On these grounds, data from real-life studies could support evidence on dual antithrombotic treatment (DAT) safety (bleeding risk) and efficacy (stent thrombosis prevention). The aim of the meta-analysis is to investigate in both randomized controlled trials (RCTs) and observational studies (Obs) the risks and/or benefits related to DAT vs. triple antithrombotic treatment (TAT) regimens in patients affected by AF undergoing PCI. MATERIALS AND METHODS: RCTs and Obs were retrieved through PubMed database. The risk ratio with 95% confidence interval was used to compare the primary and the safety endpoints. RESULTS: Meta-analysis demonstrated no significant differences between DAT vs. TAT for mortality. However, a two-fold higher mortality rate was registered in Obs than in RCTs. The Obs did not confirm the expected significant reduction in bleeding risk shown by the RCTs; however, the bleeding rates in Obs were more than three-fold those of RCTs. In Obs, a significant greater risk for stent thrombosis was observed in DAT than in TAT. CONCLUSIONS: The safety and efficacy outcomes observed in RCTs are unrealistic with respect to the current clinical practice. So, more evidence is needed to have more exhaustive guidelines based on RCTs with homogeneous designs and protocols that should mimic real-life population and practice. [ABSTRACT FROM AUTHOR]

Published
2023

2. Testosterone-to-estradiol ratio and platelet thromboxane release in ischemic heart disease: the EVA project

Author

Raparelli, V., Nocella, C., Proietti, M., Romiti, G. F., Corica, B., Bartimoccia, S., Stefanini, L., Lenzi, A., Viceconte, N., Tanzilli, G., Cammisotto, V., Pilote, L., Cangemi, R., Basili, S., and Carnevale, R.

Abstract

Background: Data on the interplay between sexual hormones balance, platelet function and clinical outcomes of adults with ischemic heart disease (IHD) are still lacking. Objective: To assess the association between the Testosterone (T)-to-Estradiol (E2) Ratio (T/E2) and platelet activation biomarkers in IHD and its predictive value on adverse outcomes. Methods: The EVA study is a prospective observational study of consecutive hospitalized adults with IHD undergoing coronary angiography and/or percutaneous coronary interventions. Serum T/E2 ratios E2, levels of thromboxane B2(TxB2) and nitrates (NO), were measured at admission and major adverse events, including all-cause mortality, were collected during a long-term follow-up. Results: Among 509 adults with IHD (mean age 67 ± 11 years, 30% females), males were older with a more adverse cluster of cardiovascular risk factors than females. Acute coronary syndrome and non-obstructive coronary artery disease were more prevalent in females versus males. The lower sex-specific T/E2 ratios identified adults with the highest level of serum TxB2and the lowest NO levels. During a median follow-up of 23.7 months, the lower sex-specific T/E2 was associated with higher all-cause mortality (HR 3.49; 95% CI 1.24–9.80; p= 0.018). In in vitro, platelets incubated with T/E2 ratios comparable to those measured in vivo in the lowest quartile showed increased platelet activation as indicated by higher levels of aggregation and TxB2production. Conclusion: Among adults with IHD, higher T/E2 ratio was associated with a lower long-term risk of fatal events. The effect of sex hormones on the platelet thromboxane release may partially explain such finding.

Published
2022
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3. Effectiveness of the new generation transcatheter aortic valve in the real life studies. Review and meta-analysis.

Author

ACCONCIA, M. C., CARETTA, Q., MONZO, L., TANZILLI, G., SCAVALLI, A. SILI, SERGI, D., DI LUOZZO, M., MARCHEI, M., CHIOCCHI, M., ROMEO, F., and GAUDIO, C.

Abstract

OBJECTIVE: The aim of the meta-analysis was to assess post-procedural outcome of the new generation of transcatheter aortic valve implantation (TAVI) devices, focusing on the transfemoral and balloon-expandable SAPIEN 3 (Edwards Lifesciences Inc., Irvine, CA, USA), the self-expanding CoreValveTM Evolut series R and PRO (R/PRO)TM (Medtronic Inc., Minneapolis, MN, USA) and ACURATE neo™ transcatheter aortic valve (Symetis SA, a Boston Scientific company, Ecublens, Switzerland). MATERIALS AND METHODS: All observational studies were retrieved through PubMed computerized database from January 2014 until June 30th, 2019. The risk difference (RD) with the 95% confidence interval (CI) was used to assess the effectiveness of the intervention under comparison. The primary end point was 30-day mortality. Safety end points included: (i) stroke, (ii) moderate/severe paravalvular leak, and (iii) the need for new permanent pacemaker implantation. RESULTS: Meta-analysis demonstrated no significant differences as regards to either 30-day mortality or stroke for all the groups of prostheses under comparison. ACURATE neo was associated with significantly less new permanent pacemaker implantation compared to SAPIEN 3 (RD: -0.06; 95% CI -0.08 to -0.03; p<0.0001; I2=0%) or to EVOLUT R/PRO (RD: -0.06; 95% CI -0.09 to -0.02; p=0.0009; I2=0%). A significant reduction of new permanent pacemaker need was observed in the group of patients implanted with SAPIEN 3 compared to EVOLUT R/PRO (RD: -0.07; 95% CI -0.09 to -0.04; p<0.00001; I2=7%). The occurrence of moderate/severe leak was significantly increased in the group of patients implanted with ACURATE neo vs. SAPIEN 3 (RD: 0.04; 95% CI 0.02 to 0.05; p<0.00001; I2=0%). No significant differences were found between ACURATE neo vs. EVOLUT R/PRO (RD: -0.01; 95% CI -0.04 to 0.02; p=0.69; I2=0%) and between SAPIEN 3 vs. EVOLUT R/PRO (RD: -0.01; 95% CI -0.04 to 0.01; p=0.28; I2=73%). CONCLUSIONS: The results of the meta-analysis show that: (1) ACURATE neo was associated with significantly less new permanent pacemaker implantation than SAPIEN 3 and EVOLUT R/PRO; (2) SAPIEN 3 had significantly lower occurrence of moderate/severe valvular leak than ACURATE neo. [ABSTRACT FROM AUTHOR]

Published
2019

4. P460 HIGH RESOLUTION ATRIOGRAM ANALYSIS AS A PREDICTIVE TOOL OF ATRIAL FIBRILLATION IN STROKE PATIENTS

Author

Rizzo, M, Imperio, G, Calcagnini, G, Censi, F, Urani, C, Tanzilli, A, Tanzilli, G, Miraldi, F, and Strano, S

Abstract

In patients (Pts) with ischemic stroke in addition to acute management, it is essential to prevent new episodes, first identifying the source of the stroke event. The primary objective of the study is to determine whether the parameters of duration, morphology (divided into the three factors optimal model order fitting, number of maximum and minimum and zero–crossing), and variability of the P wave, calculated with appropriate algorithms from high resolution recordings, correlate with the risk of developing atrial fibrillation (AF) in ischemic stroke Pts. As a secondary goal we have analyzed the differences of factors that are currently used in clinical practice for risk stratification.

Published
2023
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5. Evaluation of hand circulation with CardioWaves photoplethysmograph device during Allen test in healthy volunteers.

Author

TANZILLI, G., TRUSCELLI, G., BARILLÀ, F., COCCO, N., PANNITTERI, G., TANZILLI, A., KINDY, S. AL, MANGIERI, E., and GAUDIO, C.

Abstract

OBJECTIVE: Radial artery occlusion is a potential complication of transradial procedures and its occurrence ranges from 0.8 to 30%. It is virtually always asymptomatic but the functional and sensorial consequences of a long acting hand hypoperfusion could go underestimated. CardioWaves is a novel photo-plethysmograh device that allows us to detect the pulse wave amplitude of the blood flowing to the hand. Our objective was to assess in normal subjects the hand blood flow supplied by radial arteries and ulnopalmar arches, respectively, by using CardioWaves device during modified Allen's test (MAT). PATIENTS AND METHODS: MAT was performed on both hands of 60 normal subjects, age ranging 21 to 66 years, without any cardiovascular factor risk. RESULTS: Photoplethysmograh and MAT showed a high positive linear correlation (r=0.93). Despite that, MAT tends to give a higher reading by between 1.05 and 1.6 sec. 11 of 120 readings (9%) by CardioWaves showed values of radial/ulnar pulse amplitude ratio more than mean + 1 SD, suggesting a significant decrease in ulnopalmar arterial circulation when radial blood flow supply would ceased. CONCLUSIONS: The CardioWaves device allows us an accurate reading of the flow because of its independency from respiratory changes. Furthemore, the evaluation of radial and ulnar pulse wave amplitude and the ratio between them would reveal an insufficient blood flow supply by the ulnar artery irrespective of the MAT results. We suggest that their assessment before performing coronary an-giography and interventions may reduce potential complication of transradial access. [ABSTRACT FROM AUTHOR]

Published
2015

6. Long-term Results of a Randomized Controlled Trial Analyzing the Role of Systematic Pre-operative Coronary Angiography before Elective Carotid Endarterectomy in Patients with Asymptomatic Coronary Artery Disease.

Author

Illuminati, G., Schneider, F., Greco, C., Mangieri, E., Schiariti, M., Tanzilli, G., Barillà, F., Paravati, V., Pizzardi, G., Calio’, F., Miraldi, F., Macrina, F., Totaro, M., Greco, E., Mazzesi, G., Tritapepe, L., Toscano, M., Vietri, F., Meyer, N., and Ricco, J.-B.

Abstract

Objectives To evaluate the potential benefit of systematic preoperative coronary-artery angiography followed by selective coronary-artery revascularization on the incidence of myocardial infarction (MI) in patients undergoing carotid endarterectomy (CEA) without a previous history of coronary artery disease (CAD). Methods We randomised 426 patients who were candidates for CEA, with no history of CAD, a normal electrocardiogram (ECG), and a normal cardiac ultrasound. In group A (n = 216) all patients underwent coronary angiography before CEA. In group B (n = 210) CEA was performed without coronary angiography. Patients were not blinded for relevant assessments during follow-up. Primary end-point was the occurrence of MI at 3.5 years. The secondary end-point was the overall survival rate. Median length of follow-up was 6.2 years. Results In group A, coronary angiography revealed significant coronary artery stenosis in 68 patients (31.5%). Among them, 66 underwent percutaneous Intervention (PCI) prior to CEA and 2 received combined CEA and coronary-artery bypass grafting (CABG). Postoperatively, no MI was observed in group A, whereas 6 MI occurred in group B, one of which was fatal ( p = .01). During the study period, 3 MI occurred in group A (1.4%) and 33 were observed in group B (15.7%), 6 of which were fatal. The Cox model demonstrated a reduced risk of MI for patients in group A receiving coronary angiography (HR,.078; 95% CI, 0.024-0.256; p < .001). In addition, patients with diabetes and patients <70 years presented with an increased risk of MI. Survival analysis at 6 years by Kaplan-Meier estimates was 95.6 ± 3.2% in Group A and 89.7 ± 3.7% in group B (Log Rank = 6.54, p = .01). Conclusions In asymptomatic coronary-artery patients, systematic coronary angiography prior to CEA followed by selective PCI or CABG significantly reduces the incidence of late MI and increases long-term survival. ( ClinicalTrials.gov number, NCT02260453 ). [ABSTRACT FROM AUTHOR]

Published
2015
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7. Glutathione sodium salt as a novel adjunctive treatment for acute myocardial infarction.

Author

Truscelli, G., Tanzilli, G., Viceconte, N., Dominici, M., Arrivi, A., Sommariva, L., Granatelli, A., Gaudio, C., and Mangieri, E.

Subjects
MYOCARDIAL infarction treatment, SODIUM salts, GLUTATHIONE, CELL death, OXIDATIVE stress, THERAPEUTIC use of antioxidants, BIOLOGICAL models, COMBINED modality therapy, MYOCARDIAL infarction, MYOCARDIAL reperfusion complications, SALT, SODIUM compounds, EVIDENCE-based medicine, TREATMENT effectiveness, PREVENTION
Abstract

Timely recanalization of infarct related artery along with effective myocardial cell reperfusion represents a major challenge in the management of STEMI. The reperfusion of coronary arteries can induce further cardiomyocyte death by generating oxidative stress, which itself can mediate myocardial damage through a number of different mechanisms. Based on experimental and clinical studies, interventions to treat reperfusion injury by antioxidants were considered to be an appropriate therapeutic option. We emphasize the hypothesis that glutathione sodium salt, a physiologic antioxidant, may be of value when administered to STEMI patients both at an early stage of myocardial reperfusion by primary angioplasty and for up to three days after the procedure, in addition to standard treatment. [ABSTRACT FROM AUTHOR]

Published
2017
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8. Systematic Preoperative Coronary Angiography and Stenting Improves Postoperative Results of Carotid Endarterectomy in Patients with Asymptomatic Coronary Artery Disease: A Randomised Controlled Trial.

Author

Illuminati, G., Ricco, J.-B., Greco, C., Mangieri, E., Calio', F., Ceccanei, G., Pacilè, M.A., Schiariti, M., Tanzilli, G., Barillà, F., Paravati, V., Mazzesi, G., Miraldi, F., and Tritapepe, L.

Subjects
ANGIOGRAPHY, SURGICAL stents, ENDARTERECTOMY, CORONARY heart disease treatment, RANDOMIZED controlled trials, ELECTROCARDIOGRAPHY, OPERATIVE surgery, LOGISTIC regression analysis
Abstract

Abstract: Objective: To evaluate the usefulness of systematic coronary angiography followed, if needed, by coronary artery angioplasty (percutaneous coronary intervention (PCI)) on the incidence of cardiac ischaemic events after carotid endarterectomy (CEA) in patients without evidence of coronary artery disease (CAD). Materials and methods: From January 2005 to December 2008, 426 patients, candidates for CEA, with no history of CAD and with normal cardiac ultrasound and electrocardiography (ECG), were randomised into two groups. In group A (n =216) all the patients had coronary angiography performed before CEA. In group B, all the patients had CEA without previous coronary angiography. In group A, 66 patients presenting significant coronary artery lesions at angiography received PCI before CEA. They subsequently underwent surgery under aspirin (100mgday−1) and clopidogrel (75mgday−1). CEA was performed within a median delay of 4 days after PCI (range: 1–8 days). Risk factors, indications for CEA and surgical techniques were comparable in both groups (p >0.05). The primary combined endpoint of the study was the incidence of postoperative myocardial ischaemic events combined with the incidence of complications of coronary angiography. Secondary endpoints were death and stroke rates after CEA and incidence of cervical haematoma. Results: Postoperative mortality was 0% in group A and 0.9% in group B (p =0.24). One postoperative stroke (0.5%) occurred in group A, and two (0.9%) in group B (p =0.62). No postoperative myocardial event was observed in group A, whereas nine ischaemic events were observed in group B, including one fatal myocardial infarction (p =0.01). Binary logistic regression analysis demonstrated that preoperative coronary angiography was the only independent variable that predicted the occurrence of postoperative coronary ischaemia after CEA. The odds ratio for coronary angiography (group A) indicated that when holding all other variables constant, a patient having preoperative coronary angiography before carotid surgery was 4 times less likely to have a cardiac ischaemic event after carotid surgery. No complications related to coronary angiography were observed and no cervical haematomas occurred in patients undergoing surgery under aspirin and clopidogrel in this study. Conclusions: Systematic preoperative coronary angiography, possibly followed by PCI, significantly reduces the incidence of postoperative myocardial events after CEA in patients without clinical evidence of CAD. [Copyright &y& Elsevier]

Published
2010
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10. Benazepril Causes in Hypertension a Greater Reduction in Left Ventricular Mass Than Does Nitrendipine: A Randomized Study Using Magnetic Resonance Imaging

Author

Gaudio, C., Tanzilli, G., Ferri, F. M., Campbell, S. Villatico, Bertocchi, F., Motolese, M., and Campa, P. P.

Abstract

To assess the comparative effects of benazepril and nitrendipine monotherapies on left ventricular mass index (LVMI) in hypertensive patients with echocardiographically determined left ventricular hypertrophy, patients with diastolic blood pressure (BP) ≥100 mm Hg were randomized to benazepril, 10 mg, or nitrendipine, 20 mg, both given once or twice daily. After 4 weeks, only the responders (diastolic BP <90 mm Hg) entered a 5-month maintenance period. At baseline, and after 3 and 6 months, LVMI was blindly estimated by means of magnetic resonance imaging (MRI) and, for comparison, by means of echocardiography. Of the 50 randomized patients, three were excluded from the study as nonresponders after 4 weeks; moreover, two patients taking benazepril and one taking nitrendipine discontinued the treatment after 2 months for adverse effects. Both monotherapies reduced systolic and diastolic BP to a similar extent. After 3 months, MRI-estimated LVMI decreased by 21.5 g/m2in the benazepril and 8.8 g/m2in the nitrendipine group, with an adjusted mean difference between the two groups of 11.1 g/m2(95% CI, 7.3-14.8 g/m2; p = 0.0001). After 6 months, it decreased by 23.6 g/m2and 10.0 g/m2, respectively, with an adjusted mean difference of 11.3 g/m2(95% CI, 7.5-15.5; p = 0.0001) in favor of benazepril. In conclusion, despite a similar antihypertensive effect, benazepril led to a greater reduction in MRI-measured LVMI than did nitrendipine (−16.2% vs. −7.2%) in hypertensive patients with left ventricular hypertrophy.

Published
1998

12. Long-term Results of a Randomized Controlled Trial Analyzing the Role of Systematic Pre-operative Coronary Angiography before Elective Carotid Endarterectomy in Patients with Asymptomatic Coronary Artery Disease.

Author

Illuminati, G., Schneider, F., Greco, C., Mangieri, E., Schiariti, M., Tanzilli, G., Barillà, F., Paravati, V., Pizzardi, G., Calio', F., Miraldi, F., Macrina, F., Totaro, M., Greco, E., Mazzesi, G., Tritapepe, L., Toscano, M., Vietri, F., Meyer, N., and Ricco, J.-B.

Published
2015
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13. Poster session 1: Wednesday 3 December 2014, 09:00-16:00 * Location: Poster area

Author

Tong, L, Huang, C, Ramalli, A, Tortoli, P, Luo, J, D'hooge, J, Tzemos, N, Mordi, I, Bishay, T, Bishay, T, Negishi, T, Hristova, K, Kurosawa, K, Bansal, M, Thavendiranathan, P, Yuda, S, Popescu, BA, Vinereanu, D, Penicka, M, Marwick, TH, study, SUCCOUR, Hamed, W, Kamel, MKA, Yaseen, RIY, El-Barbary, HSE, Nemes, A, Kis, O, Gavaller, H, Kanyo, E, Forster, T, Angelis, A, Vlachopoulos, C, Ioakimidis, N, Felekos, I, Chrysohoou, C, Aznaouridis, K, Abdelrasoul, M, Terentes, D, Ageli, K, Stefanadis, C, Kurnicka, K, Domienik-Karlowicz, J, Lichodziejewska, B, Goliszek, S, Grudzka, K, Krupa, M, Dzikowska-Diduch, O, Ciurzynski, M, Pruszczyk, P, Gual Capllonch, F, Lopez Ayerbe, J, Teis, A, Ferrer, E, Vallejo, N, Junca, G, Pla, R, Bayes-Genis, A, Schwaiger, JP, Knight, DS, Gallimore, A, Schreiber, BE, Handler, C, Coghlan, JG, Bruno, R M, Giardini, G, Malacrida, S, Catuzzo, B, Armenia, S, Brustia, R, Ghiadoni, L, Cauchy, E, Pratali, L, Kim, KH, Lee, KJ, Cho, JY, Yoon, HJ, Ahn, Y, Jeong, MH, Cho, JG, Park, JC, Cho, SK, Nastase, O, Enache, R, Mateescu, AD, Botezatu, D, Popescu, BA, Ginghina, C, Gu, H, Sinha, MD, Simpson, JM, Chowienczyk, PJ, Fazlinezhad, A, Tashakori Behesthi, AHMAD, Homaei, FATEME, Mostafavi, H, Hosseini, G, Bakaeiyan, M, Boutsikou, M, Petrou, E, Dimopoulos, A, Dritsas, A, Leontiadis, E, Karatasakis, G, Sahin, S T, Yurdakul, S, Yilmaz, N, Cengiz, B, Cagatay, Y, Aytekin, S, Yavuz, S, Karlsen, S, Dahlslett, T, Grenne, B, Sjoli, B, Smiseth, OA, Edvardsen, T, Brunvand, H, Nasr, G, Nasr, A, Eleraki, A, Elrefai, S, Mordi, I, Sonecki, P, Tzemos, N, Gustafsson, U, Naar, J, Stahlberg, M, Cerne, A, Capotosto, L, Rosato, E, D'angeli, I, Azzano, A, Truscelli, G, De Maio, M, Salsano, F, Terzano, C, Mangieri, E, Vitarelli, A, Renard, S, Najih, H, Mancini, J, Jacquier, A, Haentjens, J, Gaubert, JY, Habib, G, Caminiti, G, D'antoni, V, D'antoni, V, Cardaci, V, Cardaci, V, Conti, V, Conti, V, Volterrani, M, Volterrani, M, Ahn, J, Kim, DH, Lee, HO, Iliuta, L, Kim, SY, Ryu, S, Ko, CW, Pyun, YS, Yoon, SJ, Lo Iudice, F, Esposito, R, Lembo, M, Santoro, C, Ballo, PC, Mondillo, S, De Simone, G, Galderisi, M, Hwang, YM, Kim, JH, Kim, JH, Moon, KW, Yoo, KD, Kim, CM, Tagliamonte, E, Rigo, F, Cirillo, T, Caruso, A, Astarita, C, Cice, G, Quaranta, G, Romano, C, Capuano, N, Calabro', R, Zagatina, A, Zhuravskaya, N, Guseva, O, Huttin, O, Benichou, M, Voilliot, D, Venner, C, Micard, E, Girerd, N, Sadoul, N, Moulin, F, Juilliere, Y, Selton-Suty, C, Baron, T, Christersson, C, Johansson, K, Flachskampf, FA, Lee, S, Lee, J, Hur, S, Park, J, Yun, JY, Song, SK, Kim, WH, Ko, JK, Nyktari, E, Bilal, S, Ali, SA, Izgi, C, Prasad, SK, Aly, MFA, Kleijn, SAK, Kandil, HIK, Kamp, OK, Beladan, CC, Calin, A, Rosca, M, Craciun, AM, Gurzun, MM, Calin, C, Enache, R, Mateescu, A, Ginghina, C, Popescu, BA, Mornos, C, Mornos, A, Ionac, A, Cozma, D, Crisan, S, Popescu, I, Ionescu, G, Petrescu, L, Camacho, S, Gamaza Chulian, S, Carmona, R, Diaz, E, Giraldez, A, Gutierrez, A, Toro, R, Benezet, J, Antonini-Canterin, F, Vriz, O, La Carrubba, S, Poli, S, Leiballi, E, Zito, C, Careri, S, Caruso, R, Pellegrinet, M, Nicolosi, GL, Kong, W, Kyu, K, Wong, R, Tay, E, Yip, J, Yeo, TC, Poh, KK, Correia, M, Delgado, A, Marmelo, B, Correia, E, Abreu, L, Cabral, C, Gama, P, Santos, O, Rahman, MT, Borges, I P, Peixoto, ECS, Peixoto, RTS, Peixoto, RTS, Marcolla, VF, Okura, H, Kanai, M, Murata, E, Kataoka, T, Stoebe, S, Tarr, A, Pfeiffer, D, Hagendorff, A, Generati, G, Bandera, F, Pellegrino, M, Alfonzetti, E, Labate, V, Guazzi, M, Kuznetsov, VA, Yaroslavskaya, EI, Pushkarev, GS, Krinochkin, DV, Zyrianov, IP, Carigi, S, Baldazzi, F, Bologna, F, Amati, S, Venturi, P, Grosseto, D, Biagetti, C, Fabbri, E, Arlotti, M, Piovaccari, G, Rahbi, H, Bin Abdulhaq, A, Tleyjeh, I, Santoro, C, Galderisi, M, Costantino, MF, Tarsia, G, Innelli, P, Dores, E, Esposito, G, Matera, A, De Simone, G, Trimarco, B, Capotosto, L, Azzano, A, Mukred, K, Ashurov, R, Tanzilli, G, Mangieri, E, Vitarelli, A, Merlo, M, Gigli, M, Stolfo, D, Pinamonti, B, Antonini Canterin, F, Muca, M, D'angelo, GA, Scapol, S, Di Nucci, M, Sinagra, G, Behaghel, A, Feneon, D, Fournet, M, Thebault, C, Martins, RP, Mabo, P, Leclercq, C, Daubert, C, Donal, E, Davinder Pal, SINGH, Prakash Chand, NEGI, Sanjeev, ASOTRA, Rajeev, MERWAH, Ankur, DWIVED, Ram Gopal, SOOD, Mzoughi, K, Zairi, I, Jabeur, M, Ben Moussa, F, Ben Chaabene, A, Kamoun, S, Mrabet, K, Fennira, S, Zargouni, A, Kraiem, S, Demkina, AE, Hashieva, FM, Krylova, NS, Kovalevskaya, EA, Potehkina, NG, Zaroui, A, Ben Said, R, Smaali, S, Rekik, B, Ben Hlima, M, Mizouni, H, Mechmeche, R, Mourali, MS, Malhotra, A, Sheikh, N, Dhutia, H, Siva, A, Narain, R, Merghani, A, Millar, L, Walker, M, Sharma, S, Papadakis, M, Siam-Tsieu, V, Mansencal, N, Arslan, M, Deblaise, J, Dubourg, O, Zaroui, A, Rekik, B, Ben Said, R, Boudiche, S, Larbi, N, Tababi, N, Hannachi, S, Mechmeche, R, Mourali, MS, Mechmeche, R, Zaroui, A, Chalbia, T, Ben Halima, M, Rekik, B, Boussada, R, Mourali, MS, Chistyakova, M V, Govorin, AV, Radaeva, EV, Lipari, P, Bonapace, S, Valbusa, F, Rossi, A, Zenari, L, Lanzoni, L, Targher, G, Canali, G, Molon, G, Barbieri, E, Novo, G, Giambanco, S, Sutera, MR, Bonomo, V, Giambanco, F, Rotolo, A, Evola, S, Assennato, P, Novo, S, Budnik, M, Piatkowski, R, Kochanowski, J, Opolski, G, Chatzistamatiou, E, Mpampatseva Vagena, I, Manakos, K, Moustakas, G, Konstantinidis, D, Memo, G, Mitsakis, O, Kasakogias, A, Syros, P, Kallikazaros, I, Park, SM, Kim, SA, Kim, MN, Shim, WJ, Marketou, M, Parthenakis, F, Kalyva, N, Pontikoglou, CH, Maragkoudakis, S, Zacharis, E, Patrianakos, A, Maragoudakis, F, Papadaki, H, Vardas, P, Rodrigues, AC, Perandini, LA, Souza, TR, Sa-Pinto, AL, Borba, E, Arruda, AL, Furtado, M, Carvalho, F, Bonfa, E, Andrade, JL, Hlubocka, Z, Malinova, V, Palecek, T, Danzig, V, Kuchynka, P, Dostalova, G, Zeman, J, Linhart, A, Chatzistamatiou, E, Konstantinidis, D, Memo, G, Mpampatzeva Vagena, I, Moustakas, G, Manakos, K, Trachanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Corut, H, Sade, LE, Ozin, B, Atar, I, Turgay, O, Muderrisoglu, H, Ledakowicz-Polak, A, Polak, L, Krauza, G, Zielinska, M, Szulik, M, Streb, W, Wozniak, A, Lenarczyk, R, Sliwinska, A, Kalarus, Z, Kukulski, T, Nogueira, MA, Branco, LM, Agapito, A, Galrinho, A, Borba, A, Teixeira, PP, Monteiro, AV, Ramos, R, Cacela, D, Cruz Ferreira, R, Guala, A, Camporeale, C, Tosello, F, Canuto, C, Ridolfi, L, Chatzistamatiou, E, Moustakas, G, Memo, G, Konstantinidis, D, Mpampatzeva Vagena, I, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Hristova, K, Marinov, R, Stamenov, G, Mihova, M, Persenska, S, Racheva, A, Plaskota, KJ, Trojnarska, O, Bartczak, A, Grajek, S, Ramush Bejiqi, RA, Retkoceri, R, Bejiqi, H, Beha, A, Surdulli, SH, Seya, M, Sasaoka, T, Hirasawa, K, Yoshikawa, S, Maejima, Y, Ashikaga, T, Hirao, K, Isobe, M, none, Dreyfus, J, Durand-Viel, G, Cimadevilla, C, Brochet, E, Vahanian, A, Messika-Zeitoun, D, Jin, CN, Fang, F, Meng, FX, Kam, K, Sun, JP, Tsui, GK, Wong, KK, Wan, S, Yu, CM, Lee, AP, Cho, I J, Chung, HM, Heo, R, Ha, SJ, Hong, GR, Shim, CY, Chang, HJ, Ha, JW, Chung, N, Moral, S, Gruosso, D, Galuppo, V, Teixido, G, Rodriguez-Palomares, JF, Gutierrez, L, Evangelista, A, Moral, S, Gruosso, D, Galuppo, V, Teixido, G, Rodriguez-Palomares, JF, Gutierrez, L, Evangelista, A, Moral, S, Gruosso, D, Galuppo, V, Teixido, G, Rodriguez-Palomares, JF, Gutierrez, L, Evangelista, A, Alexopoulos, Alexan, Dawson, David, Nihoyannopoulos, Petros, Zainal Abidin, H A, Ismail, JOHAN, Arshad, KAMAL, Ibrahim, ZUBIN, Lim, CW, Abd Rahman, E, Kasim, SAZZLI, Peteiro, J, Barrio, A, Escudero, A, Bouzas-Mosquera, A, Yanez, J, Martinez, D, Castro-Beiras, A, Scali, MC, Simioniuc, A, Mandoli, GE, Lombardo, A, Massaro, F, Di Bello, V, Marzilli, M, Dini, FL, Adachi, H, Tomono, J, Oshima, S, Merchan Ortega, G, Bravo Bustos, D, Lazaro Garcia, R, Sanchez Espino, AD, Macancela Quinones, JJ, Ikuta, I, Ruiz Lopez, MF, Valencia Serrano, FM, Bonaque Gonzalez, JC, Gomez Recio, M, Romano, G, D'ancona, G, Pilato, G, Di Gesaro, G, Clemenza, F, Raffa, G, Scardulla, C, Sciacca, S, Lancellotti, P, Pilato, M, Addetia, K, Takeuchi, M, Maffessanti, F, Weinert, L, Hamilton, J, Mor-Avi, V, Lang, RM, Sugano, A, Seo, Y, Watabe, H, Kakefuda, Y, Aihara, H, Nishina, H, Ishizu, T, Fumikura, Y, Noguchi, Y, Aonuma, K, Luo, XX, Fang, F, Lee, APW, Shang, Q, Yu, CM, Sammut, E C, Chabinok, R, Jackson, T, Siarkos, M, Lee, L, Carr-White, G, Rajani, R, Kapetanakis, S, Byrne, D, Walsh, JP, Ellis, L, Mckiernan, S, Norris, S, King, G, Murphy, RT, Hristova, K, Katova, TZ, Simova, I, Kostova, V, Shuie, I, Ferferieva, V, Bogdanova, V, Castelon, X, Nemes, A, Sasi, V, Domsik, P, Kalapos, A, Lengyel, C, Orosz, A, Forster, T, Grapsa, J, Demir, O, Dawson, D, Sharma, R, Senior, R, Nihoyannopoulos, P, Pilichowska, E, Zaborska, B, Baran, J, Stec, S, Kulakowski, P, Budaj, A, Herrera, J E, Palacios, I F, Mendoza, I, Marquez, J A, Herrera, J A, Octavio, J A, Dempaire, G, Rotolo, M, Kosmala, W, Kaye, G, Saito, M, Negishi, K, Marwick, TH, Maceira Gonzalez, A M, Ripoll, C, Cosin-Sales, J, Igual, B, Salazar, J, Belloch, V, Dulai, R S, Taylor, A, and Gupta, S

Abstract

Purpose: We have previously demonstrated that multi-line transmit (MLT) beam forming can provide high quality full field-of-view (90° sector) B-mode images at very high frame rates, i.e. up to 500 fps. The purpose of this study was to test the feasibility of this technique in imaging the mechanical intraventricular waves such as the one associated with activation of the left ventricle. Methods: A dedicated pulse sequence using MLT was implemented on the ULA-OP research scanner equipped with a 2.0 MHz phased array to obtain 90° sector images at a frame rate of 436 fps. The left ventricle of a healthy volunteer was imaged from the apical 4 chamber view and the RF data was acquired. Subsequently, the strain rate was extracted from the RF data using a normalized cross-correlation method. Results: As expected, during the early filling phase, myocardium lengthening (positive strain rate) was observed propagating from the base of the septum to the apex and back (Figure a). A similar wave was detected in the lateral wall, although a brief shortening (negative strain rate) was detected in the mid-wall which could be the result of reverberations (Figure b). During isovolumetric contraction, the septal wall shortened before the lateral wall (as expected) - moreover - there seemed to be an intra-wall base-apex shortening gradient (Figure c and d). Conclusions: Our preliminary results show that visualization of the cardiac mechanical activation could be feasible using MLT based high frame rate imaging. Further research is required to examine this in depth, which is the topic of on-going work. Figure Curved M-mode of strain rate

Published
2014
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14. MODERATED POSTER SESSION: Deformation and multimodality imaging in congenital heart: Thursday 4 December 2014, 08:30-18:00 * Location: Moderated Poster area

Author

West, C, Garcia-Aranda Dominguez, B, Alonso-Gonzalez, R, Li, W, Uebing, A, Cruz, C, Lebreiro, A, Pinho, T, Dias, C, Silva Cardoso, J, Julia Maciel, M, Pirat, B, Varan, B, Erdogan, I, Sade, LE, Muderrisoglu, H, Cruz, C, Lebreiro, A, Pinho, T, Dias, C, Silva Cardoso, J, Julia Maciel, M, Mateescu, A, Enache, R, Nastase, O, Botezatu, D, Popescu, BA, Ginghina, C, Di Salvo, G, D'aiello, AF, Del Gaizo, F, Rea, A, Capogrosso, C, Russo, MG, Capotosto, L, D'angeli, I, Placanica, A, Ashurov, R, Placanica, G, Tanzilli, G, Mangieri, E, Vitarelli, A, Grosse-Wortmann, L, Compton, G, Dragulescu, A, Nield, L, Ierano, P, Esposito, R, Santoro, C, De Stefano, F, Muscariello, R, Buonauro, A, Tufano, A, Galderisi, M, Cantinotti, M, Assanta, N, Crocetti, M, Marotta, M, Scalese, M, Molinaro, S, Murzi, B, De Lucia, V, Spadoni, I, Iervasi, G, Gaisenok, O, Martsevich, S YU, and Deev, A D

Abstract

Aim: There is wealth of data on the echocardiographic evaluation of prosthetic valves in the aortic or mitral position. Similar data are missing for the Melody percutaneous pulmonary valve system (MPPV). We aimed to correlate the anatomic appearance of the MPPV with the haemodynamic result on invasive and echocardiographic assessment. Patients and Methods: All 45 patients who underwent MPPV implantation at our institution between 2007-2013 were studied (median age 30 [range 11-61] years). All patients had complex congenital heart disease. The narrowest dimensions of the MPPV system were taken from the final biplane orthogonal fluoroscopic images to calculate the effective valve opening area (EOA). The post implantation invasive peak-to-peak gradient (ΔPp-p) and the maximal and mean Doppler gradient (ΔPmax and ΔPmean) on the pre-discharge echocardiogram (within 72 hours of implantation) were also obtained. Results: ΔPp-p after valve implantation was low (11.5±5.2 [range 2-20] mmHg) and there was no significant residual pulmonary regurgitation. The peak and mean gradient across the valve by Doppler assessment were significantly higher than ΔPp-p (ΔPmean: 19.3±6.5, ΔPmax: 33.3±8.2 mmHg; P<0.0001 for both vs. ΔPp-p). Both Doppler gradients correlated significantly with the invasive peak gradient (ΔPp-p vs. ΔPmean: r=0.37, P=0.03; ΔPp-p vs. ΔPmax: r=0.39, P=0.02) The EOA of the valve system indexed to body surface area was 132±30 mm2/m2. There were only weak relationships between the indexed EOA and the invasive and Doppler gradients (correlations with EOA: ΔPp-p: r=-0.32, P=0.06; ΔPpeak: r=-0.33, P=0.045; ΔPmean: r=-0.23; P=0.16). Conclusion: Doppler assessment of the percutaneous Melody valve early after implantation consistently overestimates the invasive peak-to-peak gradient. Simple estimates of valve size do not allow prediction of central haemodynamics. These results reflect the complex and variable anatomy of the right ventricular outflow tract/ main pulmonary artery in this group of patients.

Published
2014
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15. MODERATED POSTER SESSION: Imaging in interventional cardiology: Wednesday 3 December 2014, 09:00-16:00 * Location: Moderated Poster area

Author

Wang, YS, Gong, X, Su, YG, Cui, J, Shu, XH, Perge, P, Kovacs, A, Liptai, C, Apor, A, Nagy, KV, Geller, L, Szeplaki, G, Merkely, B, Goebel, B, Hamadanchi, A, Schmidt-Winter, C, Otto, S, Jung, C, Figulla, HR, Poerner, TC, Rotzak, R, Aharonovich, A, Geva, Y, Rozenman, Y, Capotosto, L, D'angeli, I, Azzano, A, Placanica, A, Mukred, K, Rinaldi, E, Ashurov, R, Tanzilli, G, Mangieri, E, Vitarelli, A, Lesevic, H, Karl, M, Rosner, S, Ott, I, Sonne, C, Borges, I P, Peixoto, ECS, Peixoto, RTS, Peixoto, RTS, Marcolla, VF, Citro, R, Baldi, C, Provenza, G, Di Maio, M, Silverio, A, Prota, C, Di Muro, M R, Bossone, E, Giudice, P, Piscione, F, Muratori, M, Fusini, L, Gripari, P, Tamborini, G, Ghulam Ali, S, Salvi, L, Bartorelli, AL, Agrifoglio, M, Alamanni, F, Pepi, M, Fusini, L, Tamborini, G, Muratori, M, Cefalu', C, Bottari, VE, Gripari, P, Ghulam Ali, S, Andreini, D, Pontone, G, and Pepi, M

Abstract

Objective: To assess left ventricular (LV) twist by three-dimensional speckle tracking imaging (3D-STI) in a pacing induced heart failure canine model with left bundle-branch block (LBBB) undergoing cardiac resynchronization therapy (CRT). Methods: After induction of left bundle branch block by radiofrequency ablation, rapid right ventricular pacing (RVP) at 200 beats/min was utilized in 22 adult beagle dogs for 6 weeks to induce heart failure. Then 15 dogs received CRT for 4 weeks and others were treated as control. Apical full-volume acquisition of the LV was obtained in conscious animals at baseline, the end of 6-week RVP and the end of 4-week CRT. Peak LV systolic twist (Ptw) and torsion (Ptor) along with peak apical and basal rotation were automatically calculated by Tom-Tec 4D LV Analysis 3.0 software to identify the ideal parameter in predicting treatment response of CRT. Results: After 4 weeks of CRT, LVEF increased [(31.97 ± 1.47) vs. (37.47 ± 3.60)%, p=0.002] and LVESV decreased [(24.13 ± 3.72) vs. (21.87 ± 3.15)ml, p=0.007] significantly in dogs with heart failure. By shortening the delay of basal rotation [(23.73 ± 9.98) vs. (17.87 ± 5.94)ms, p=0.009], CRT improved peak LV systolic twist [(6.88 ± 0.99) vs. (8.03 ± 0.63)°, p=0.008] and torsion [(1.21 ± 0.36) vs. (1.98 ± 0.39)°/cm, p=0.010] instead of peak apical [(5.97 ± 0.57) vs. (6.13 ± 0.61)°, p=0.103] and basal rotation [(2.08 ± 0.45) vs. (2.13 ± 0.46)°, p=0.469]. CRT treatment response, defined as improvement of LVESV≥15%, was observed in 9 dogs. Significant difference was found in Ptw [(7.43 ± 0.61) vs. (6.06 ± 0.89)°, p=0.016] and Ptor [(1.43 ± 0.45) vs. (0.67 ± 0.36)°/cm, p=0.042] between responders and nonresponders. The cut-off values derived from receiver-operating characteristic curve analysis were 6.73° for Ptw and 1.00°/cm for Ptor with satisfying sensitivity as 89% and 85%, specificity as 83% and 84%, respectively. Conclusions: CRT improved LV systolic twist and reversed LV remodeling by reconciling basal with apical rotation. Peak twist and torsion evaluated by 3D-STI demonstrated potential prediction value for treatment response of CRT.

Published
2014
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