4 results on '"Troshina, Ekaterina"'
Search Results
2. Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial
- Author
-
Garvey, W Timothy, Frias, Juan P, Jastreboff, Ania M, le Roux, Carel W, Sattar, Naveed, Aizenberg, Diego, Mao, Huzhang, Zhang, Shuyu, Ahmad, Nadia N, Bunck, Mathijs C, Benabbad, Imane, Zhang, Xiaotian M, Abalos, Franklin H., Manghi, Federico C.P., Zaidman, Cesar J., Vico, Marisa L., Aizenberg, Diego, Costanzo, Pablo R., Serra, Leonardo P., MacKinnon, Ignacio J., Hissa, Miguel N., Vidotti, Maria H., Kerr Saraiva, Jose F., Alves, Breno B., Franco, Denise R., Moratto, Otavio, Murthy, Sreenivasa, Goyal, Ghanshyam, Yamasaki, Yoshimitsu, Sato, Nobuyuki, Inoue, Satoshi, Asakura, Taro, Shestakova, Marina, Khaykina, Elena, Troshina, Ekaterina, Vorokhobina, Natalia, Ametov, Alexander, Tu, Shih-Te, Yang, Chwen-Yi, Lee, I-Te, Huang, Chien-Ning, Ou, Horng-Yih, Freeman, George, Machineni, Sriram, Klein, Klara, Sultan, Senan, Parsa, Alan, Otero-Martinez, Juan, Gonzalez, Alex, Bhargava, Anuj, Brian, Susan, Ince, Carlos, Plantholt, Stephen, Cole, Jeremy, Lacour, Audrey, Vega, Damaris, de Souza, Jose, Rohlf, Jane L., St. John, Roy C., Horowitz, Barry, Audish, Hanid, Galindo, Rodolfo, Umpiperrez, Guillermo, Ard, Jamy, Curtis, Brian, Garvey, William T., Fraser, Neil J., Mandry, Jose, Mohseni, Rizwana, Mayfield, Ronald, Powell, Talessa, Vance, Carl, Ong, Stephen, Lewy-Alterbaum, Ana L., Murray, Alexander, Al-Karadsheh, Amer, Yacoub, Tamer, Roberts, Kevin, Fried, David L., Rosenstock, Julio, Pulla, Bharathi, Bode, Bruce, Frias, Juan, Klaff, Leslie, Brazg, Ronald, Van, Joanna, Tan, Anjanette, Briskin, Toby, Rhee, Margaret, Chaicha-Brom, Tira, Hartley, Paul A., Nunez, Lazaro, Cortes-Maisonet, Gregorio, Soucie, Gary, Hsia, Stanley, and Jones, Thomas
- Abstract
Weight reduction is essential for improving health outcomes in people with obesity and type 2 diabetes. We assessed the efficacy and safety of tirzepatide, a glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, versus placebo, for weight management in people living with obesity and type 2 diabetes.
- Published
- 2023
- Full Text
- View/download PDF
3. 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial
- Author
-
le Roux, Carel W, Astrup, Arne, Fujioka, Ken, Greenway, Frank, Lau, David C W, Van Gaal, Luc, Ortiz, Rafael Violante, Wilding, John P H, Skjøth, Trine V, Manning, Linda Shapiro, Pi-Sunyer, Xavier, Hamann, Andreas, Barakat, Alain, Blüher, Matthias, Linn, Thomas, Mölle, Andrea, Segner, Alexander, Stübler, Petra, Tosch-Sisting, Regina, Pacini, Furio, Santini, Ferruccio, Marchesini, Giulio, Rotella, Carlo Maria, Invitti, Cecilia, Vettor, Roberto, Buscemi, Silvio, Raya, Pedro Mezquita, Freijoo, Felipe Casanueva, de Barbará, Ramón Gomis, Carraro, Raffaele, Bobillo, Enrique Romero, de la Cuesta, Carmen, Farsang, Csaba, Csaszar, Albert, Zahorska-Markiewicz, Barbara, Pupek-Musialik, Danuta, Franek, Edward, Ostrowska, Lucyna, Olszanecka-Glinianowicz, Magdalena, Lalic, Nebojsa, Micic, Dragan, Ludvik, Bernhard, Paulweber, Bernhard, Prager, Rudolf, Scheen, André, Van Gaal, Luc, Astrup, Arne Vernon, Hermansen, Kjeld, Madsbad, Sten, Rissanen, Aila, Nieminen, Sakari, Savolainen, Markku, Krempf, Michel, Romon, Monique, Laville, Martine, Marre, Michel, Mira, Reginald, Finucane, Francis, Veenendaal, Aletha, van Berkum, Frank, Johannsson-Vidarsdóttir, Solrun, Van de Walle, Vivienne, Meesters, Eelco, Hjelmesæth, Jøran, Klemsdal, Tor Ole, Kulseng, Bård, Bach-Kliegel, Birgit, Laederach, Kurt, Villiger, Lukas, Golay, Alain, Bilz, Stefan, Sathyapalan, Thozhukat, Bain, Stephen, Kumar, Sudesh, Le Roux, Carel Wynard, Lean, Michael E.J., McGowan, Barbara, Rehman, Tariq, Wilding, John, Wittert, Gary, Caterson, Ian, Proietto, Joeseph, Prins, John, Neto, Bruno Geloneze, Gross, Jorge Luiz, Chacra, Antonio Roberto, Halpern, Alfredo, de Almeida Suplicy, Henrique, Chow, Francis Chun Chung, Thacker, Hemant P, Chadha, Manoj, Chandalia, Hemaraj, Unnikrishnan, Ambika, Kalra, Sanjay, Deshpande, Neeta, Shunmugavelu, Minakshi, Deshmukh, Vaishali Chetan, Maislos, Maximo, Lieberman, Gabriella Segal, Shimon, Ilan, Stern, Naftali, Nabriski, Dan, Karnieli, Eddy, Shehadeh, Naim, Gonzalez-Galvez, Guillermo, del Rosario Arechavaleta-Granell, Maria, Ortiz, Rafael Margarito Violante, Franco, Guadalupe Morales, Gurieva, Irina, Suplotova, Lyudmila Aleksandrovna, Troshina, Ekaterina, Ruyatkina, Ludmila Aleksandrovna, Voychik, Emma Anatolievna, Martsevich, Sergey, Startseva, Maria A, Seeber, Mary Elizabeth, Badat, Aysha, Ellis, Graham, Altuntas, Yuksel, Guler, Serdar, Ulgen, Ender, Delibasi, Tuncay, Chetty, Tony, Hart, Randy, Janzen, Jeannette, Labonte, Isabelle, Lau, David, Liutkus, Joanne, O'Keefe, Dennis, Padwal, Raj, Ransom, Thomas P.P., Tytus, Richard, Weisnagel, Stanley John, Adler, Jay, Aqua, Keith, Aronoff, Stephen L, Bedel, Gary W., Blevins, Thomas Craig, Blumenau, Joe, Brockmyre, Andrew Peter, Call, Robert S, Canadas, Rafael, Chaykin, Louis B, Cohen, Kenneth, Conrow, Jeffrey Keith, Davis, Matthew G, Downey, H Jackson, Drosman, Steven Richard, Duckor, Steven, Farmer, H. Frank, Farrell, James, Fehnel, Stephen, Finneran, Matthew Patrick, Forbes, Ray, Forker, Alan, Fredrick, Mark, Fujioka, Ken, Geller, Steven Andrew, Gill, Santosh, Glaser, Linda, Greco, Susan Neims, Greenway, Frank Lyons, Harper, Wayne, Herman, Lee, Hoekstra, John, Ingebretsen, Richard, Ison, Rodney, Jain, Rajeev K, Kaplan, Roy, Kaster, Steven Richard, Haase, Gregory A, Kerzner, Boris, Kirstein, Judith Lee, Koltun, William, Krieger, Diane R, Lewis, Cora Elizabeth, Madder, Robert, Marple, Richard N, McDermott, Edward J, Mello, Curtis John, Miller, Alan B., Mullen, Julie, Nardandrea, John, O'Neil, Patrick, Pi-Sunyer, F. Xavier, Pucillo, Ronald M, Rhee, Chanhaeng, Redrick, Scott, Pardini, Aaron, Rothman, Jeffrey, Rubino, Domenica Marie, Sellers, Gladstone, Smith, Timothy, Byars, William David, Soufer, Joseph, Sussman, Allen Michael, Patrick, Kyle, Schramm, Erich Lloyd, Van Cleeff, Martin, Berg, Saul Reuel, Wyatt, Holly Roxanna, and Simon, James Alan
- Abstract
Liraglutide 3·0 mg was shown to reduce bodyweight and improve glucose metabolism after the 56-week period of this trial, one of four trials in the SCALE programme. In the 3-year assessment of the SCALE Obesity and Prediabetes trial we aimed to evaluate the proportion of individuals with prediabetes who were diagnosed with type 2 diabetes.
- Published
- 2017
- Full Text
- View/download PDF
4. Diagnostic performance of late-night salivary cortisol measured by automated electrochemiluminescence immunoassay in obese and overweight patients referred to exclude Cushing’s syndrome
- Author
-
Belaya, Zhanna, Iljin, Alexander, Melnichenko, Galina, Rozhinskaya, Liudmila, Dragunova, Natalia, Dzeranova, Larisa, Butrova, Svetlana, Troshina, Ekaterina, and Dedov, Ivan
- Abstract
Abstract: This study estimates diagnostic performance of late-night salivary cortisol (LNSC) as measured by automated electrochemiluminescence immunoassay (ECLIA), evaluates the clinical implication of two consecutive LNSC measurements, and compares its accuracy with enzyme-linked immunosorbent assay (ELISA) and serum cortisol after low-dose dexamethasone suppression test (DST) in obese and overweight patients referred for suspected Cushing’s syndrome (CS). One hundred twenty three consecutive obese and overweight referred patients and 98 healthy volunteers provided two saliva samples collected at 23:00 using a Salivette (Sarstedt, Germany), assayed by ECLIA (Cobas e601) and ELISA. The patients underwent DST and were further evaluated until CS was pathologically confirmed (n = 45) or excluded. Diagnostic performance of LNSC was evaluated by receiver operating characteristic (ROC) analysis. The total areas under the curve (AUC) were calculated to compare the different tests. We found that a cut-off value of 9.4 nmol/l can differentiate CS among obese and overweight patients with sensitivity of 84.4 % (95% CI 71.2–92.2), specificity of 92.3 % (95% CI 84.2–96.4), and diagnostic odds ratio of 65.1 (95% CI 20.4–207.6). No difference was found between AUCs from the first, second, and the mean from the two LNSC measurements (ECLIA), LNSC (ELISA), or DST. The single LNSC (ECLIA) and DST improved the sensitivity and specificity for concordant results up to 100 and 97.4 %, respectively. In conclusion, due to its automation and its comparable diagnostic performance, ECLIA is preferable as a first-line LNSC screening test for CS. The initial use of single LNSC followed by DST provides better diagnostic performance for concordant results.
- Published
- 2012
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.