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The study was aimed to evaluate the inhibitory activity towards angiotensin converting enzyme I (ACE-I), antioxidant capacity and phenolics of Alchemilla vulgaris (lady’s mantle) naturally grows in Turkey. Aqueous extracts of lady’s mantle were used for enzyme inhibition assay on angiotensin converting enzyme I purified from sheep lungs. Trolox equivalent antioxidant capacity (TEAC) and DPPH assays were also used for monitoring of antioxidant profile of methanolic and aqueous extracts. Total phenolics of the extracts from lady’s mantle were also analyzed. Our research results indicated that lady’s mantle could have important anti-hypertensive effects due to their potent inhibitory activity towards angiotensin converting enzyme I.

SARS-CoV-2 is a novel coronavirus with a major outbreak of unusual viral epidemic in Wuhan, China. To date, some certain vaccines have been approved by FDA so that spelling the end of pandemic globally but COVID-19 is still a global leading cause of death, with a descending rates. The existence of antiviral properties of ribosome inactivating proteins towards many human, animal and plant viruses are well-known for so many years. Ribosome inactivating proteins are naturally occurring substances and toxic N-glycosidase enzymes which depurinate both eukaryotic and prokaryotic rRNAs, hence arresting protein synthesis in the coarse of translation. Interestingly, some ribosome inactivating proteins can also remove the purine nucleotides from non-ribosomal RNAs. Undoubtly, removing the rRNA purine nucleotides effects the protein synthesis and therefore, triggers ribotoxic stress response that commences apoptosis. These proteins might similarly hamper specifically the viral circles in one and/or more points in their lifecycle. In present study, we have focused on naturally occurring ribosome inactivating proteins as promising agents for struggle against Covid-19 disease.