1. Amphotericin B Tamed by Salicylic Acid
- Author
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Yuming Yu, Peng Chen, Ming Gao, Wei Lan, Shijun Sun, Ziwei Ma, Rome Sultani, Yincang Cui, Muhammad Naveed Umar, Sher Wali Khan, Xiaodong Cai, Zhenjiang Liang, and Hui Tan
- Subjects
General Chemical Engineering ,General Chemistry - Abstract
Although Amphotericin B (AmB) is considered as the "gold standard" treatment for deep fungal infections, owing to its excellent antifungal effect, it often causes severe hemolytic toxicity and nephrotoxicity, which limits its clinical use. We designed and synthesized AmB derivatives by attaching salicylic acid (SA) to the carboxyl group and confirmed their structures using
- Published
- 2021