1. Tumor stromal desmoplasia and inflammatory response uniquely predict survival with and without stratification for HPV tumor infection in OPSCC patients.
- Author
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Haave H, Gulati S, Brekke J, Lybak S, Vintermyr OK, and Aarstad HJ
- Subjects
- Adult, Aged, Biopsy, Needle, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell therapy, Cohort Studies, Combined Modality Therapy, Disease-Free Survival, Female, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Male, Middle Aged, Mouth Neoplasms mortality, Mouth Neoplasms pathology, Mouth Neoplasms therapy, Mouth Neoplasms virology, Norway, Oropharyngeal Neoplasms pathology, Oropharyngeal Neoplasms therapy, Papillomavirus Infections mortality, Papillomavirus Infections therapy, Prognosis, Retrospective Studies, Statistics, Nonparametric, Survival Analysis, Tumor Virus Infections mortality, Tumor Virus Infections therapy, Carcinoma, Squamous Cell mortality, Oropharyngeal Neoplasms mortality, Oropharyngeal Neoplasms virology, Papillomavirus Infections prevention & control, Tumor Virus Infections pathology
- Abstract
Background: Oropharyngeal squamous cell carcinoma (OPSCC) positive for human papillomavirus (HPV) increases wolrd wide., Aims/objectives: The objective for this study has been to evaluate tumor phenotypes and tumor host responses with respect to five-year disease-specific survival (DSS) in HPV(+) and HPV(-) patients., Material and Methods: Two hundred patients with OPSCC have been treated between 1992 and 2010. Histopathology slides from these patients have been morphologically evaluated in formalin-fixed, paraffin-embedded (FFPE) stained with hematoxylin-eosin (HE). From HE-stained sections tumor phenotype (keratinization, fraction of mature cancer cells and pattern of invasion) and tumor host responses (inflammation and stromal desmoplasia) were evaluated with respect to five years DSS., Results: High tumor inflammatory response and low stromal desmoplasia had an independent effect predicting better five-year DSS among all patients and when analyzed separately in the HPV(-) and HPV(+) cohort of patients using a Cox regression survival analysis that also included standard clinical prognostic variables among OPSCC patients., Conclusion: Tumor host responses, inflammation and stromal desmoplasia may become part of routine work-up in OPSCC patients due to prognostic value., Significance: We present a method, accessible in most clinical locations and would give important additional information about prognosis in OPSCC patients.
- Published
- 2018
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