1. SIGNALING PATHWAYS REGULATED BY
- Author
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Abdulrahman L, Al-Malki, Elie K, Barbour, Huwait, Ea, Said S, Moselhy, Anas Hassan Saeed, ALZahrani, and Taha A, Kumosani
- Subjects
Glycation End Products, Advanced ,Male ,Camelus ,Interleukin-6 ,Plant Extracts ,Tumor Necrosis Factor-alpha ,neurodegeneration ,Brain ,Neurodegenerative Diseases ,Antioxidants ,Article ,Rats ,Random Allocation ,Whey Proteins ,Cadmium Chloride ,Brassicaceae extract ,Brassicaceae ,Cyclic AMP ,Whey protein ,Animals ,Drug Therapy, Combination ,Signal Transduction - Abstract
Background: The goal of this study was identification signaling molecules mediated the formation of AGEs in brain of rats injected with CdCl2 and the role of camel whey proteins and Brassicaceae extract on formation of AGEs in brain. Methods: Ninety male rats were randomly grouped into five groups; Normal control (GpI) and the other rats (groups II-V) were received a single dose of cadmium chloride i.p (5 μg/kg/b.w) for induction of neurodegeneration. Rats in groups III-V were treated daily with whey protein (1g/kg b.w) or Brassicaceae extract (1mg/kg b.w) or combined respectively for 12 weeks. Results: It was found that whey protein combined with Brassicaceae extract prevented the formation of AGEs and enhance the antioxidant activity compared with untreated group (p
- Published
- 2017