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Your search keyword '"NISHIMURA, Masaharu"' showing total 18 results
Start Over Author "NISHIMURA, Masaharu" Journal allergology international
18 results on '"NISHIMURA, Masaharu"'

8. Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation

Author

Oguma, Akira, primary, Shimizu, Kaoruko, additional, Kimura, Hirokazu, additional, Tanabe, Naoya, additional, Sato, Susumu, additional, Yokota, Isao, additional, Takimoto-Sato, Michiko, additional, Matsumoto-Sasaki, Machiko, additional, Abe, Yuki, additional, Takei, Nozomu, additional, Goudarzi, Houman, additional, Suzuki, Masaru, additional, Makita, Hironi, additional, Hirai, Toyohiro, additional, Nishimura, Masaharu, additional, and Konno, Satoshi, additional

Published
2022
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10. Association of abdominal visceral adiposity with sputum IL-5 levels in asthma

Author

Goudarzi, Houman, primary, Kimura, Hirokazu, additional, Makita, Hironi, additional, Abe, Yuki, additional, Oguma, Akira, additional, Sato, Michiko, additional, Matsumoto, Munehiro, additional, Takei, Nozomu, additional, Kimura, Hiroki, additional, Shimizu, Kaoruko, additional, Suzuki, Masaru, additional, Ito, Yoichi M., additional, Nishimura, Masaharu, additional, and Konno, Satoshi, additional

Published
2021
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12. Prevalence and clinical impact of asthma-COPD overlap in severe asthma

Author

Wakazono, Miho, Kimura, Hirokazu, Tsujino, Ichizo, Wakazono, Nobuyasu, Takimoto-Sato, Michiko, Matsumoto, Munehiro, Shimizu, Kaoruko, Goudarzi, Houman, Makita, Hironi, Nishimura, Masaharu, and Konno, Satoshi

Abstract

Patients with asthma-COPD overlap (ACO) have a greater symptom burden, worse respiratory function, and more frequent exacerbations than those with asthma alone. However, only a few studies have investigated the prevalence and clinical course of ACO in severe asthma. This study aimed to examine the comorbid rate of ACO and its clinical impact on severe asthma.

Published
2024
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14. A Distinct Sensitization Pattern Associated with Asthma and the Thymic Stromal Lymphopoietin (TSLP) Genotype

Author

Iijima, Hiroaki, primary, Kaneko, Yoshiko, additional, Yamada, Hideyasu, additional, Yatagai, Yohei, additional, Masuko, Hironori, additional, Sakamoto, Tohru, additional, Naito, Takashi, additional, Hirota, Tomomitsu, additional, Tamari, Mayumi, additional, Konno, Satoshi, additional, Nishimura, Masaharu, additional, Noguchi, Emiko, additional, and Hizawa, Nobuyuki, additional

Published
2013
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15. Genetic association of the functional CDHR3genotype with early-onset adult asthma in Japanese populations

Author

Kanazawa, Jun, Masuko, Hironori, Yatagai, Yohei, Sakamoto, Tohru, Yamada, Hideyasu, Kaneko, Yoshiko, Kitazawa, Haruna, Iijima, Hiroaki, Naito, Takashi, Saito, Takefumi, Noguchi, Emiko, Konno, Satoshi, Nishimura, Masaharu, Hirota, Tomomitsu, Tamari, Mayumi, and Hizawa, Nobuyuki

Abstract

Recent studies have demonstrated that a coding SNP (rs6967330, Cys529→Tyr) in cadherin-related family member 3 (CDHR3), which was previously associated with wheezing illness and hospitalizations in infancy, could support efficient human rhinovirus C (RV-C) entry and replication. Here, we sought to examine the genetic contribution of this variant to the development of adult asthma.

Published
2017
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17. Genetic Impact of a Butyrophilin-like 2 (BTNL2) Gene Variation on Specific IgE Responsiveness to Dermatophagoides farinae(Der f) in Japanese

Author

Konno, Satoshi, Takahashi, Daisuke, Hizawa, Nobuyuki, Hattori, Takeshi, Takahashi, Ayumu, Isada, Akira, Maeda, Yukiko, Huang, Shau-Ku, and Nishimura, Masaharu

Abstract

Background:Dermatophagoides farinae(Derf) is one of the most frequently implicated allergens in several allergic diseases. Several genome-wide screens have identified a linkage between chromosome 6p21 and mite-specific IgE responsiveness. Butyrophilin-like 2 (BTNL2) is a member of the immunoglobulin superfamily and, on the basis of its homology to B7-1, has been implicated as a costimulatory molecule involved in T-cell activation. BTNL2 resides in the HLA region on chromosome 6p21, and significant associations between BTNL2 gene polymorphisms and several inflammatory diseases have been reported.

Published
2009
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18. Asthma Phenotypes in Japanese Adults - Their Associations with the CCL5 and ADRB2 Genotypes.

Author

Kaneko, Yoshiko, Masuko, Hironori, Sakamoto, Tohru, Iijima, Hiroaki, Naito, Takashi, Yatagai, Yohei, Yamada, Hideyasu, Konno, Satoshi, Nishimura, Masaharu, Noguchi, Emiko, and Hizawa, Nobuyuki

Subjects
*GENETICS of asthma, *PHENOTYPES, *JAPANESE people, *GENOTYPE-environment interaction, *GENETIC polymorphism research, *DISEASES
Abstract

Background: Cluster analyses were previously performed to identify asthma phenotypes underlying asthma syndrome. Although a large number of patients with asthma develop the disease later in life, these previous cluster analyses focused mainly patients with younger-onset asthma. Methods: Cluster analysis examined the existence of distinct phenotypes of late-onset asthma in Japanese patients with adult asthma. We then associated genotypes at the CCL5, TSLP, IL4, and ADRB2 genes with the clusters of asthma identified. Results: Using the 8 variables of age, sex, age at onset of the disease, smoking status, total serum IgE, %FEVi, FEVi/FVC, and specific IgE responsiveness to common inhaled allergens, two-step cluster analysis of 880 Japanese adult asthma patients identified 6 phenotypes: cluster A (n = 155): older age at onset, no airflow obstruction; cluster B (n = 170): childhood onset, normal-to-mild airflow obstruction; cluster C (n = 119): childhood onset, the longest disease duration, and moderate-to-severe airflow obstruction; cluster D {n = 108): older age at onset, severe airflow obstruction; cluster E (n = 130): middle-age at onset, no airflow obstruction; and cluster F {n = 198): older age at onset, mild-to-moderate airflow obstruction. The CC/_5-28C>G genotype was significantly associated with clusters A, B and D (OR 1.65, p = 0.0021; 1.67, 0.018; and 1.74, 0.01, respectively). The ADRB2 Arg16Gly genotype was also associated with clusters B and D (OR 0.47, p = 0.0004; and 0.63, 0.034, respectively). Conclusions: The current cluster analysis identified meaningful adult asthma phenotypes linked to the functional CCL5 and ADRB2 genotypes. Genetic and phenotypic data have the potential to elucidate the pheno-typic heterogeneity and pathophysiology of asthma. [ABSTRACT FROM AUTHOR]

Published
2013
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