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Start Over Descriptor "Axonal transport -- Physiological aspects" Journal american journal of human genetics
1 results on '"Axonal transport -- Physiological aspects"'

1. Novel locus for autosomal dominant hereditary spastic paraplegia, on chromosome 8q

Subjects
Genetic disorders -- Research, Chromosome mapping -- Usage, Spasticity -- Genetic aspects, Paraplegia -- Genetic aspects, Nervous system -- Degeneration, Mitochondria -- Physiological aspects, Axonal transport -- Physiological aspects, Biological sciences
Abstract

Autosomal dominant hereditary spastic paraplegia (HSP) has been shown, through analysis of a Caucasian kindred, to have a novel locus on chromosome 8q23-24. The locus takes in 6.2 cM between D8S1804 and D8S1774, and several potential candidate genes exist. Genetic loci exist on chromosomes 2p, 14q and 15q, but those loci are not a fit in 45% of autosomal dominant HSP kindreds.

Published
1999

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