1. "Sandwich" Diimine‐Copper Catalysts for C−H Functionalization by Carbene Insertion.
- Author
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Klimovica, Kristine, Heidlas, Julius X., Romero, Irvin, Le, Thanh V., and Daugulis, Olafs
- Subjects
CATALYSTS ,DIAZO compounds ,DIAZOMETHANE ,ETHERS ,IMINES - Abstract
We report here "sandwich" diimine‐copper(I) catalysts for C(sp3)−H bond functionalization. Reactions of alkanes and ethers with trimethylsilyldiazomethane, ethyl diazoacetate, and trifluoromethyl‐diazomethane have been demonstrated. We also report C(sp3)−H bond methylation, benzylation, and diphenylmethylation by diazomethane, aryldiazomethanes, and diphenyldiazomethane. These reactions are rare examples of base‐metal catalyzed, intermolecular C(sp3)−H functionalizations by employing unactivated diazo compounds. Electrophilicity and unique steric environment of "sandwich"‐copper catalysts are likely reasons for their catalytic efficiency. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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