1. TTF-1 and surfactant-B as co-adjuvants in the diagnosis of lung adenocarcinoma and pleural mesothelioma.
- Author
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Bakir K, Koçer NE, Deniz H, and Güldür ME
- Subjects
- Adenocarcinoma metabolism, Biomarkers, Tumor metabolism, Diagnosis, Differential, Humans, Lung Neoplasms metabolism, Mesothelioma metabolism, Pleural Neoplasms metabolism, Reproducibility of Results, Retrospective Studies, Thyroid Nuclear Factor 1, Adenocarcinoma diagnosis, Lung Neoplasms diagnosis, Mesothelioma diagnosis, Nuclear Proteins metabolism, Pleural Neoplasms diagnosis, Pulmonary Surfactant-Associated Protein B metabolism, Transcription Factors metabolism
- Abstract
Primary lung adenocarcinomas and metastatic adenocarcinomas may show a great morphologic resemblance to malignant mesothelioma. There are numerous immunohistochemical markers being used, but none of them were proved to be effective enough to reach a certain diagnosis. The current study was performed to evaluate the utility of thyroid transcription factor-1 (TTF-1) and surfactant protein-B (SP-B) expression in the differential diagnosis between lung adenocarcinomas and pleural mesotheliomas. In this retrospective study, TTF-1 and SP-B were applied to 30 cases with adenocarcinoma and 15 cases with pleural mesothelioma, immunohistochemically, using an avidin-biotin detection system. Twenty percent of adenocarcinomas and 13.3% of pleural mesothelioma stained positive for SP-B. TTF-1 stained 24 of the 30 adenocarcinomas (80%) and none of the 15 mesotheliomas (0%). TTF-1 positivity in adenocarcinomas was found to be statistically significant, while SP-B had no important practical value either used alone or in combination with TTF-1. There was no statistically significant correlation between the differentiation level of adenocarcinomas and TTF-1 staining pattern. In conclusion, we believe that TTF-1 may be helpful in distinguishing lung adenocarcinoma from pleural mesothelioma.
- Published
- 2004
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