1. Urinary YKL-40 as a Candidate Biomarker for Febrile Urinary Tract Infection in Young Children
- Author
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Juyoung Lee, Jin Soon Suh, Kyoung Soon Cho, Joong Hyun Bin, Hyun Hee Kim, and Mi Hae Chung
- Subjects
Male ,Clinical Biochemistry ,030232 urology & nephrology ,Urine ,Gastroenterology ,General Laboratory Medicine ,chemistry.chemical_compound ,0302 clinical medicine ,Medicine ,030212 general & internal medicine ,Pyuria ,Children ,Urinary tract infection ,medicine.diagnostic_test ,biology ,General Medicine ,Klebsiella pneumoniae ,C-Reactive Protein ,Area Under Curve ,Creatinine ,Urinary Tract Infections ,Biomarker (medicine) ,Original Article ,Female ,medicine.symptom ,Glomerular Filtration Rate ,musculoskeletal diseases ,medicine.medical_specialty ,YKL-40 ,Fever ,Urinalysis ,Urinary system ,Urology ,Renal function ,03 medical and health sciences ,Internal medicine ,Escherichia coli ,Humans ,Chitinase-3-Like Protein 1 ,business.industry ,Biochemistry (medical) ,C-reactive protein ,Infant ,Biomarker ,ROC Curve ,chemistry ,biology.protein ,business ,Biomarkers - Abstract
Background Given that YKL-40 is a known marker of inflammation, we sought to determine its association with urinary tract infection (UTI) in febrile children. Methods In total, 44 children aged 0 to 24 months with febrile UTI and 35 age- and sex-matched controls with fever from other causes were enrolled in the study. ELISA was performed to determine the level of YKL-40 in urine collected from each child. Results The ratio of urinary YKL-40 to creatinine (Cr) was higher in the children with a UTI than in the controls (P
- Published
- 2018