1. Efficacy of single-dose azithromycin in treatment of acute otitis media in children after a baseline tympanocentesis
- Author
-
Judy A. Krogstad, Jean Chow, Chandra Khurana, P. Fernández, Richard H. Schwartz, Mary M. Aspin, Michael W. Dunne, Adib Rodriguez, Sergio L. Vargas, Paz Emparanza, Irmeli Roine, Adriano Arguedas Mohs, John K. Podgore, Samuel Mclinn, Jeffrey L. Blumer, Antonio Arrieta, Mark M. Blatter, Garth D. Ehrlich, and Willis M. Gooch
- Subjects
Male ,Cure rate ,medicine.medical_specialty ,Acute otitis media ,Azithromycin ,Clinical Therapeutics ,Body weight ,medicine.disease_cause ,Haemophilus influenzae ,Internal medicine ,Streptococcus pneumoniae ,Tympanocentesis ,Medicine ,Humans ,Pharmacology (medical) ,Pharmacology ,business.industry ,Dosing regimen ,Infant ,Combined Modality Therapy ,Surgery ,Anti-Bacterial Agents ,Otitis Media ,Infectious Diseases ,Child, Preschool ,Drainage ,Female ,business ,medicine.drug - Abstract
Children with acute otitis media underwent tympanocentesis and were given a single dose of 30 mg of azithromycin/kg of body weight. At day 28, the overall clinical cure rate was 206 of 242 (85%). Clinical cure rates for patients infected with Streptococcus pneumoniae (67 of 76; 88%) and Haemophilus influenzae (28 of 44; 64%) were consistent with historical rates for the 5-day dosing regimen.
- Published
- 2003