1. Dectin-1 Fc targeting of aspergillus fumigatus beta-glucans augments innate defense against invasive pulmonary aspergillosis.
- Author
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Mattila PE, Metz AE, Rapaka RR, Bauer LD, and Steele C
- Subjects
- Animals, Aspergillosis immunology, Aspergillosis microbiology, Aspergillosis mortality, Aspergillus fumigatus metabolism, Immunity, Innate, Immunoglobulin Fc Fragments chemistry, Immunoglobulin Fc Fragments immunology, Lectins, C-Type, Lung Diseases, Fungal immunology, Lung Diseases, Fungal microbiology, Lung Diseases, Fungal mortality, Macrophages, Alveolar immunology, Male, Membrane Proteins chemistry, Membrane Proteins immunology, Mice, Mice, Inbred C57BL, Nerve Tissue Proteins chemistry, Nerve Tissue Proteins immunology, Aspergillosis therapy, Aspergillus fumigatus immunology, Immunoglobulin Fc Fragments therapeutic use, Lung Diseases, Fungal therapy, Membrane Proteins therapeutic use, Nerve Tissue Proteins therapeutic use, beta-Glucans immunology
- Abstract
Invasive pulmonary aspergillosis (IPA) has significantly increased over the last decade. Here, a fusion protein consisting of the Dectin-1 extracellular domain linked to the Fc portion of murine immunoglobulin G1 augmented alveolar macrophage killing of Aspergillus fumigatus and shifted mortality associated with IPA via attenuation of A. fumigatus growth in the lung.
- Published
- 2008
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