1. Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection.
- Author
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Chang J, Schul W, Yip A, Xu X, Guo JT, and Block TM
- Subjects
- Animals, Dengue mortality, Dengue pathology, Mice, Survival Analysis, Treatment Outcome, Antiviral Agents administration & dosage, Dengue drug therapy, Dengue prevention & control, Enzyme Inhibitors administration & dosage, Glycoside Hydrolase Inhibitors
- Abstract
Dengue virus infection causes diseases in people, ranging from the acute febrile illness dengue fever, to life-threatening dengue hemorrhagic fever/dengue shock syndrome. We previously reported that a host cellular α-glucosidases I and II inhibitor, imino sugar CM-10-18, potently inhibited dengue virus replication in cultured cells, and significantly reduced viremia in dengue virus infected AG129 mice. In this report we show that CM-10-18 also significantly protects mice from death and/or disease progress in two mouse models of lethal dengue virus infection. Our results thus provide a strong support for the development of CM-10-18 or its derivatives as antiviral agents to treat servere dengue virus infections., (Copyright © 2011 Elsevier B.V. All rights reserved.)
- Published
- 2011
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