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Your search keyword '"Xu, Xiaodong"' showing total 2 results
Start Over Author "Xu, Xiaodong" Topic antiviral agents Journal antiviral research
2 results on '"Xu, Xiaodong"'

1. Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses.

Author

Chang, Jinhong, Warren, Travis K., Zhao, Xuesen, Gill, Tina, Guo, Fang, Wang, Lijuan, Comunale, Mary Ann, Du, Yanming, Alonzi, Dominic S., Yu, Wenquan, Ye, Hong, Liu, Fei, Guo, Ju-Tao, Mehta, Anand, Cuconati, Andrea, Butters, Terry D., Bavari, Sina, Xu, Xiaodong, and Block, Timothy M.

Subjects
*BETA-glucosidase, *ENZYME inhibitors, *HEMORRHAGIC fever, *ANTIVIRAL agents, *STRUCTURE-activity relationship in pharmacology, *IN vitro studies
Abstract

Highlights: [•] Three imino sugars (IHVR11029, 17028 and 19029), were identified through SAR study of 120 derivatives. [•] These three imino sugars demonstrated broad antiviral activities against HFVs in vitro, and in vivo. [•] All three compounds inhibited ER α-glucosidases in vitro and in vivo. [Copyright &y& Elsevier]

Published
2013
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2. Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection

Author

Chang, Jinhong, Schul, Wouter, Yip, Andy, Xu, Xiaodong, Guo, Ju-Tao, and Block, Timothy M.

Subjects
*GLUCOSIDASES, *DENGUE, *HOST-virus relationships, *DENGUE viruses, *VIREMIA, *ANTIVIRAL agents, *IMINOSUGARS, *LABORATORY mice
Abstract

Abstract: Dengue virus infection causes diseases in people, ranging from the acute febrile illness dengue fever, to life-threatening dengue hemorrhagic fever/dengue shock syndrome. We previously reported that a host cellular α-glucosidases I and II inhibitor, imino sugar CM-10–18, potently inhibited dengue virus replication in cultured cells, and significantly reduced viremia in dengue virus infected AG129 mice. In this report we show that CM-10–18 also significantly protects mice from death and/or disease progress in two mouse models of lethal dengue virus infection. Our results thus provide a strong support for the development of CM-10–18 or its derivatives as antiviral agents to treat servere dengue virus infections. [Copyright &y& Elsevier]

Published
2011
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