1. Protective effect and mechanism of low P50 haemoglobin oxygen carrier on isolated rat heart.
- Author
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Zhou, Wentao, Li, Shen, Hao, Shasha, Zhang, Honghui, Li, Tao, Li, Wanjing, Liu, Jiaxin, Wang, Hong, and Yang, Chengmin
- Subjects
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MYOCARDIAL reperfusion , *OXYGEN carriers , *MYOCARDIAL infarction , *HEMOGLOBINS , *MYOCARDIAL ischemia , *PATHOLOGICAL physiology , *HEART - Abstract
The protection of the isolated heart is very important in heart transplantation surgery, meanwhile, the ischaemia/reperfusion (I/R) of the isolated heart is the main cause of its damage. A timely supply of oxygen can significantly improve the prevention of myocardial ischaemia, however, the cardioprotective solution does not have an oxygen supply function. Haemoglobin Based on Oxygen Carriers (HBOCs) is a kind of nano-oxygen drug, which can effectively and timely supply oxygen to hypoxic organs and tissues. However, the oxygen-carrying and releasing capacity (P50) is different with different HBOCs. The aim of our study was to investigate whether STS (a kind of cardioprotective solution, St Thomas Solution) +different P50 HBOCs provide superior myocardial protection and decrease myocardial injury compared to only STS in rats Langendorff isolated heart perfusion model. The results showed that STS + HBOCs can improve cardiac function at 37 °C for 35 min and 120 min, and reduce myocardial infarctions, pathological changes, and apoptosis of cardiomyocytes, and the STS + low P50 HBOCs is more effective than the other two higher P50 HBOCs. We further demonstrated the outstanding protective effect of STS + low P50 HBOCs on cardiac function, reducing myocardial infarctions and apoptosis of cardiomyocytes in rat Langendorff isolated heart perfusion model. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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