1. Determination of endocrine-disrupting chemicals in human milk by dispersive liquid-liquid microextraction
- Author
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L.M. Iribarne-Durán, F. Vela-Soria, Laura Serrano-López, José Ramón Ortega Pérez, Juan P. Arrebola, Nicolás Olea, I. Jiménez-Díaz, Caridad Díaz, and Mariana F. Fernández
- Subjects
Liquid Phase Microextraction ,Clinical Biochemistry ,Parabens ,Food Contamination ,010501 environmental sciences ,Endocrine Disruptors ,01 natural sciences ,Analytical Chemistry ,chemistry.chemical_compound ,Benzophenones ,Phenols ,Limit of Detection ,Tandem Mass Spectrometry ,Biomonitoring ,Liquid liquid ,Humans ,General Pharmacology, Toxicology and Pharmaceutics ,Benzhydryl Compounds ,Chromatography, High Pressure Liquid ,0105 earth and related environmental sciences ,Chromatography ,Milk, Human ,Chemistry ,010401 analytical chemistry ,General Medicine ,0104 chemical sciences ,Medical Laboratory Technology ,Environmental chemistry ,Xenobiotic - Abstract
Aim: Human populations are widely exposed to numerous so-called endocrine-disrupting chemicals, exogenous compounds able to interfere with the endocrine system. This exposure has been associated with several health disorders. New analytical procedures are needed for biomonitoring these xenobiotics in human matrices. A quick and inexpensive methodological procedure, based on sample treatment by dispersive liquid–liquid microextraction, is proposed for the determination of bisphenols, parabens and benzophenones in samples. Results: LOQs ranged from 0.4 to 0.7 ng ml-1 and RSDs from 4.3 to 14.8%. Conclusion: This methodology was satisfactorily applied in the simultaneous determination of a wide range of endocrine-disrupting chemicals in human milk samples and is suitable for application in biomonitoring studies.
- Published
- 2016