Search

Your search keyword '"Liu, Rui"' showing total 1 results
Start Over Author "Liu, Rui" Topic cellular signal transduction Topic gene expression Journal biochemical & biophysical research communications
1 results on '"Liu, Rui"'

1. AG490 inhibits NFATc1 expression and STAT3 activation during RANKL induced osteoclastogenesis.

Author

Li, Chang-hong, Zhao, Jin-xia, Sun, Lin, Yao, Zhong-qiang, Deng, Xiao-li, Liu, Rui, and Liu, Xiang-yuan

Subjects
*GENE expression, *ENZYME inhibitors, *ENZYME activation, *CELL proliferation, *CELL cycle, *CELLULAR signal transduction
Abstract

Highlights: [•] AG490 inhibits RANKL-induced osteoclastogenesis in RAW264.7 cells. [•] AG490 affects cell proliferation and cell cycle distribution. [•] AG490 reduces NFATc1 expression during RANKL-induced osteoclastogenesis. [•] AG490 disrupts the activation of RANKL-mediated JAK2/STAT3 signaling pathway. [•] STAT3 depletion partly mimics the effect of AG490 on RANKL-induced osteoclastogenesis. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results