1. N,N-Dimethylsphingosine−Coumarin: Synthesis, Chemical Characterization, and Biological Evaluation
- Author
-
David Farquhar, Sukhen C. Ghosh, Jim Klostergaard, and Edmond Auzenne
- Subjects
Membrane Potential, Mitochondrial ,Pharmacology ,Membrane potential ,Chemistry ,Stereochemistry ,Organic Chemistry ,Biomedical Engineering ,Pharmaceutical Science ,Bioengineering ,Tumor cells ,Coumarin ,Coumarin synthesis ,Sphingolipid ,Mitochondria ,chemistry.chemical_compound ,Microscopy, Fluorescence ,Biochemistry ,Coumarins ,Sphingosine ,Cell Line, Tumor ,Humans ,Mitochondrial localization ,Cytotoxicity ,Biotechnology ,Biological evaluation - Abstract
Coumarin derivatives of N,N-dimethylsphingosine (DMSP) were prepared and chemically characterized. They were apparently biologically equivalent to DMSP in terms of tumor cell cytotoxicity and were used to establish the rapid mitochondrial localization of this sphingolipid in tumor cells, followed closely by its marked reduction of mitochondrial membrane potential.
- Published
- 2007
- Full Text
- View/download PDF