1. The Course of Disease in Major Depressive Disorder Is Associated With Altered Activity of the Limbic System During Negative Emotion Processing
- Author
-
Ronny Redlich, Katharina Dohm, Tim Hahn, Udo Dannlowski, Stefanie Probst, Axel Krug, Elisabeth J. Leehr, Igor Nenadic, Lena Waltemate, Tina Meller, Dominik Grotegerd, Kai Ringwald, Simon Schmitt, Jonathan Repple, Fabian Breuer, Katharina Brosch, Frederike Stein, Carina Hülsmann, Tilo Kircher, Julia-Katharina Pfarr, Susanne Meinert, Katharina Thiel, Andreas Jansen, Janik Goltermann, Nils Opel, Melissa Klug, Antonia Warneke, Hannah Lemke, Verena Enneking, and Alexandra Winter
- Subjects
Male ,medicine.medical_specialty ,Cognitive Neuroscience ,Emotions ,Hippocampus ,Audiology ,behavioral disciplines and activities ,Amygdala ,050105 experimental psychology ,Disease course ,03 medical and health sciences ,0302 clinical medicine ,Limbic system ,mental disorders ,Limbic System ,medicine ,Humans ,0501 psychology and cognitive sciences ,Radiology, Nuclear Medicine and imaging ,Biological Psychiatry ,Depression (differential diagnoses) ,Depressive Disorder, Major ,medicine.diagnostic_test ,business.industry ,05 social sciences ,medicine.disease ,Magnetic Resonance Imaging ,Cross-Sectional Studies ,medicine.anatomical_structure ,nervous system ,Major depressive disorder ,Female ,Neurology (clinical) ,Functional magnetic resonance imaging ,business ,Insula ,030217 neurology & neurosurgery - Abstract
Background Brain functional alterations during emotion processing in patients with major depressive disorder (MDD) compared with healthy control subjects (HCs) are frequently reported. However, evidence for functional correlates of emotion processing with regard to MDD trajectories is scarce. This study investigates the role of lifetime disease course for limbic brain activation during negative emotional face processing in patients with MDD. Methods In a large sample of patients with MDD (n = 333; 58.55% female) and HCs (n = 333; 60.06% female), brain activation was investigated during a negative emotional face-processing task within a cross-sectional design. Differences between HC and MDD groups were analyzed. Previous disease course, characterized by 2 components, namely hospitalization and duration of illness, was regressed on brain activation of the amygdala, (para-)hippocampus, and insula in patients with MDD. Results Patients with MDD showed increased activation in the amygdala, insula, and hippocampus compared with HCs (all p values corrected for familywise error [pFWE] .057). Conclusions This study investigated negative emotion processing in a large sample of patients with MDD and HCs. Our results confirm limbic hyperactivation in patients with MDD during negative emotion processing; however, this hyperactivation may resolve with a more severe lifetime disease course in the insula and (para-)hippocampus—brain regions involved in emotion processing and regulation. These findings need further replication in longitudinal studies.
- Published
- 2022