1. PRP Treatment Efficacy for Tendinopathy: A Review of Basic Science Studies
- Author
-
Zhou, Yiqin and Wang, James H-C.
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Basic science ,animal diseases ,lcsh:Medicine ,Review Article ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Intensive care medicine ,Inflammation ,030222 orthopedics ,General Immunology and Microbiology ,Platelet-Rich Plasma ,business.industry ,lcsh:R ,General Medicine ,medicine.disease ,Treatment efficacy ,nervous system diseases ,3. Good health ,Clinical trial ,030104 developmental biology ,Platelet-rich plasma ,Tendinopathy ,Orthopedic surgery ,Physical therapy ,business - Abstract
Platelet-Rich Plasma (PRP) has been widely used in orthopaedic surgery and sport medicine to treat tendon injuries. However, the efficacy of PRP treatment for tendinopathy is controversial. This paper focuses on reviewing the basic science studies on PRP performed under well-controlled conditions. Bothin vitroandin vivostudies describe PRP’s anabolic and anti-inflammatory effects on tendons. While some clinical trials support these findings, others refute them. In this review, we discuss the effectiveness of PRP to treat tendon injuries with evidence presented in basic science studies and the potential reasons for the controversial results in clinical trials. Finally, we comment on the approaches that may be required to improve the efficacy of PRP treatment for tendinopathy.
- Published
- 2016