1. Effects Of Amitryptilin Administration on Rat Sera and Brain Beta-endorphins
- Author
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Radivoj Jadrić, Sabaheta Hasić, Emina Kiseljaković, Jovan Radovanović, Emina Ićindić-Nakaš, and Mira Winterhalter-Jadrić
- Subjects
amitryptilin ,beta-endorphins ,rat ,sera ,brain ,Biology (General) ,QH301-705.5 - Abstract
The aim of our study was to establish the influence of antidepressive drugs on serum and brain beta-endorphins in experimental animals. Experiment was performed on albino Wistar rats. Antidepressant amitryptiline was used, and for quantification of sera and brain beta-endorphins RIA technique. Our results showed difference between sera and brain beta-endorphins concentration in amitryptiline pretreated animals, vs. those in serum and brain of control group treated with 0.95% NaCl. This study shows that use of psychoactive drugs have influence on sera and brain beta-endorphins concentration. Beta-endorphins could be of great importance, used as markers for evaluation of antidepressant drug effects.
- Published
- 2006
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