1. Unprecedented sugar bridged bisindoles selective inhibiting glioma stem cells.
- Author
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Wei, Xin, Dai, Zhi, Yang, Jing, Khan, Afsar, Yu, Hao-Fei, Zhao, Yun-Li, Wang, Yi-Fen, Liu, Ya-Ping, Yang, Zi-Feng, Huang, Wan-Yi, Wang, Xin-Hua, Zhao, Xu-Dong, and Luo, Xiao-Dong
- Subjects
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GLIOMAS , *CANCER stem cells , *CELL-mediated cytotoxicity , *TUMOR necrosis factors , *GENE expression , *APOPTOSIS - Abstract
Unlike reported bisindoles linked by single bond directly, alstoniasidines A ( 1 ) and B ( 2 ), from Alstonia scholaris featuring unprecedented skeleton with two indole moieties bridged by a sugar, represented a novel bisindole type having strictosamide-glucopyranose-picraline scaffold. Both compounds exhibited selective cytotoxicity against human glioma stem cells (GSCs) and induced caspase-3 dependent extrinsic apoptosis by increasing the expression of interleukin 1 (IL-1), tumor necrosis factor (TNF-α), and the cleaved caspase-3, while damaged the unlimited proliferation and self-renewal capacity of GSCs. This finding might provide new type of leads for the selective killing of human glioma stem cells. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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