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Your search keyword '"Bunker, Jeffrey J."' showing total 2 results
Start Over Author "Bunker, Jeffrey J." Journal bioorganic & medicinal chemistry letters
2 results on '"Bunker, Jeffrey J."'

2. N 5-Phosphonoacetyl-l-ornithine (PALO): A convenient synthesis and investigation of influence on regulation of amino acid biosynthetic genes in Saccharomyces cerevisiae

Author

Johnson, Brad, Steadman, Rachel, Patefield, Krista D., Bunker, Jeffrey J., Atkin, Audrey L., and Dussault, Patrick

Subjects
*SACCHAROMYCES cerevisiae, *AMINO acid synthesis, *GENETIC regulation, *BIOSYNTHESIS, *ARGININE, *ORNITHINE carbamoyltransferase, *ENZYME inhibitors, *GENE expression
Abstract

Abstract: A scalable four-step synthesis of the ornithine transcarbamylase inhibitor N 5-phosphonoacetyl-l-ornithine (PALO) is achieved through boroxazolidinone protection of ornithine. Investigations in the model organism Saccharomyces cerevisiae found that, in contrast to a previous report, PALO did not influence growth rate or expression of genes involved in arginine metabolism. [Copyright &y& Elsevier]

Published
2011
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