1. Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors
- Author
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Ki Ho Lee, Jae Du Ha, Sang-Hyeup Lee, Seung Jun Kim, Sung-Soo Kim, Dae Gwin Jeong, Hwan Mook Kim, Chang Woo Lee, Woul Seong Park, Suk-Kyeong Jung, Joong-Kwon Choi, Song Kyu Park, Sung Yun Cho, Seong Eon Ryu, Seung Kyu Kang, and Jin Hee Ahn
- Subjects
Rhodanine ,Clinical Biochemistry ,Pharmaceutical Science ,Naphthalenes ,Biochemistry ,Chemical synthesis ,Mice ,Structure-Activity Relationship ,chemistry.chemical_compound ,Cell Line, Tumor ,Drug Discovery ,Animals ,Humans ,Structure–activity relationship ,Enzyme Inhibitors ,Molecular Biology ,IC50 ,chemistry.chemical_classification ,Aldehydes ,Molecular Structure ,biology ,Organic Chemistry ,Biological activity ,In vitro ,Enzyme ,chemistry ,Enzyme inhibitor ,biology.protein ,Molecular Medicine ,Protein Tyrosine Phosphatases ,Protein Binding - Abstract
A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 microM in vitro and showed a reduced invasion in cell-based assay.
- Published
- 2006