1. Overview of recent developments of pyrazole derivatives as an anticancer agent in different cell line.
- Author
-
Bennani FE, Doudach L, Cherrah Y, Ramli Y, Karrouchi K, Ansar M, and Faouzi MEA
- Subjects
- Animals, Antineoplastic Agents chemical synthesis, Cell Line, Tumor, Chemistry Techniques, Synthetic, Drug Design, Drug Discovery, Drug Screening Assays, Antitumor, Humans, Neoplasms pathology, Pyrazoles chemical synthesis, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Neoplasms drug therapy, Pyrazoles chemistry, Pyrazoles pharmacology
- Abstract
Pyrazole is a five-membered aromatic heterocyclic ring with two adjacent nitrogen atoms C
3 H3 N2 H.The presence of this nucleus in pharmacological agents of various therapeutic categories gifts a broad spectrum of biological activities and pharmaceuticals that contain pyrazole like celecoxib (anti-inflammatory), CDPPB (antipsychotic), Rimonabant (anti-obesity), Difenamizole, (Analgesic), Betazole (H2 receptor agonist), Fezolamide (Antidepressant), etc… The pharmacological potential of the pyrazole fraction is proved in many publication where they synthesized and evaluated pyrazoles against several biological agents. The aim of this article review is to survey recent works linking pyrazole structures to anticancer activities corresponding to 9 different type of cancer., (Copyright © 2019 Elsevier Inc. All rights reserved.)- Published
- 2020
- Full Text
- View/download PDF