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1. DABCO-catalyzed one-pot three component synthesis of dihydropyrano[3,2-c]chromene substituted quinazolines and their evaluation towards anticancer activity.

Author

Vodnala S, Bhavani AK, Kamutam R, Naidu VG, Promila, and Prabhakar Ch

Subjects
Antineoplastic Agents metabolism, Antineoplastic Agents toxicity, Binding Sites, Catalysis, Catalytic Domain, Cell Line, Tumor, Cell Survival drug effects, Estrogen Receptor alpha chemistry, Estrogen Receptor alpha metabolism, Humans, Hydrogen Bonding, Molecular Docking Simulation, Thermodynamics, Antineoplastic Agents chemical synthesis, Benzopyrans chemistry, Piperazines chemistry, Quinazolines chemistry
Abstract

A facile DABCO promoted one-pot three component synthesis of a new series of C-C linked bis-heterocycle containing dihydropyrano[c]chromene as highly fused oxa-heteryl group at C-2 position of quinazoline was developed. Quinazoline-2-carbaldehyde, substituted 4-hydroxycoumarin and ethyl cyanoacetate were used as key components in the Knoevenagel-Michael addition reaction to get the titled compounds. These compounds were screened for anti-cancer activity against the breast cancer cell lines of MDA-MB 231, and MDA-MB 453., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

Published
2016
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