1. Oncogene HER-2 in Canine Mammary Gland Carcinomas
- Author
-
Yolanda Millán, S. Ramón y Cajal, J. Ordás, J. Martín de las Mulas, and V. Fernández-Soria
- Subjects
Canine Mammary Carcinoma ,Cancer Research ,Oncogene ,Mammary gland ,Chromogenic in situ hybridization ,Biology ,medicine.disease ,Breast cancer ,medicine.anatomical_structure ,Oncology ,medicine ,Carcinoma ,Cancer research ,Immunohistochemistry ,CISH - Abstract
Immunohistochemical (IHC) HER-2/neu protein overexpression was found in 17.6% of canine mammary gland carcinomas, a percentage similar to that observed in human breast carcinoma, but there was no gene amplification by chromogenic in situ hybridization (CISH). Canine mammary carcinoma would be a suitable natural model of that subset of human breast carcinomas with HER-2 protein overexpression without gene amplification.
- Published
- 2003
- Full Text
- View/download PDF