1. CyclicPepedia: a knowledge base of natural and synthetic cyclic peptides.
- Author
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Liu, Lei, Yang, Liu, Cao, Suqi, Gao, Zhigang, Yang, Bin, Zhang, Guoqing, Zhu, Ruixin, and Wu, Dingfeng
- Subjects
CYCLIC peptides ,PEPTIDOMIMETICS ,KNOWLEDGE base ,DRUG patents ,PATENT applications - Abstract
Cyclic peptides offer a range of notable advantages, including potent antibacterial properties, high binding affinity and specificity to target molecules, and minimal toxicity, making them highly promising candidates for drug development. However, a comprehensive database that consolidates both synthetically derived and naturally occurring cyclic peptides is conspicuously absent. To address this void, we introduce CyclicPepedia (https://www.biosino.org/iMAC/cyclicpepedia/), a pioneering database that encompasses 8744 known cyclic peptides. This repository, structured as a composite knowledge network, offers a wealth of information encompassing various aspects of cyclic peptides, such as cyclic peptides' sources, categorizations, structural characteristics, pharmacokinetic profiles, physicochemical properties, patented drug applications, and a collection of crucial publications. Supported by a user-friendly knowledge retrieval system and calculation tools specifically designed for cyclic peptides, CyclicPepedia will be able to facilitate advancements in cyclic peptide drug development. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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