1. The combination of strong expression of ZNF143 and high MIB-1 labelling index independently predicts shorter disease-specific survival in lung adenocarcinoma
- Author
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Yuichiro Kawatsu, Li Zhi, Seichi Horie, Sohsuke Yamada, Fumihiro Tanaka, Yasuyuki Sasaguri, Hiroto Izumi, Kimitoshi Kohno, Toru Takeda, Shohei Kitada, Hidetaka Uramoto, and Tomoko Kimura
- Subjects
Adult ,Male ,Cancer Research ,Pathology ,medicine.medical_specialty ,Mitotic index ,Lung Neoplasms ,Molecular Sequence Data ,Biology ,Adenocarcinoma ,Immunoenzyme Techniques ,Labelling ,medicine ,Mitotic Index ,cell growth ,Humans ,Neoplasm Invasiveness ,Amino Acid Sequence ,neoplasms ,Molecular Diagnostics ,Survival analysis ,Aged ,Retrospective Studies ,Aged, 80 and over ,Lung ,Disease specific survival ,Cell Differentiation ,Middle Aged ,medicine.disease ,lung adenocarcinoma ,MIB-1 ,Prognosis ,Survival Analysis ,digestive system diseases ,Peptide Fragments ,Neoplasm Proteins ,ZNF143 ,medicine.anatomical_structure ,Ki-67 Antigen ,Treatment Outcome ,Oncology ,Immunoenzyme techniques ,Cancer research ,Trans-Activators ,Female ,Neoplasm Grading ,Cell Division - Abstract
Background: The transcription factor, zinc finger protein 143 (ZNF143), positively regulates many cell-cycle-related genes. The ZNF143 would show high expression of multiple solid tumours related closely to cancer cell growth, similar to the widely accepted Ki67 (MIB-1) protein, but the underlying mechanisms for ZNF143 remain unclear. We investigated the association of ZNF143 expression with clinicopathological features and prognoses of patients with lung adenocarcinoma. Methods: Expressions of ZNF143 and MIB-1 were immunohistochemically analysed in 183 paraffin-embedded tumour samples of patients with lung adenocarcinoma. The ZNF143 expression was considered to be strong when >30% of the cancer cells demonstrated positive staining. Results: Strong ZNF143+ expression showed a significantly close relationship to pathologically moderate to poor differentiation and highly invasive characteristics. The ZNF143 positivity potentially induced cell growth of lung adenocarcinoma, correlated significantly with high MIB-1 labelling index (⩾10%). Univariate and multivariate analyses demonstrated that both strong ZNF143+ and the high MIB-1 index group have only and significantly worse survival rates. Conclusions: The combination of strong ZNF143 expression and high MIB-1 index potentially predicts high proliferating activity and poor prognosis in patients with lung adenocarcinoma, and may offer a therapeutic target against ZNF143.
- Published
- 2014