1. Biological Activity of Agaricinic Acid Nanoparticles against Human Hepatoma HepG2 Cells.
- Author
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Gudkova OI, Demchenko AG, Shvets AV, Kuryakov VN, Sedyakina NE, Lyundup AV, Feldman NB, Gromovykh TI, and Lutsenko SV
- Subjects
- Alkanes isolation & purification, Antineoplastic Agents isolation & purification, Cell Survival drug effects, Dose-Response Relationship, Drug, Fruiting Bodies, Fungal chemistry, Hep G2 Cells, Humans, Particle Size, Tricarboxylic Acids isolation & purification, Alkanes pharmacology, Antineoplastic Agents pharmacology, Coriolaceae chemistry, Nanoparticles chemistry, Tricarboxylic Acids pharmacology
- Abstract
A stable preparation of agaricinic acid nanoparticles was obtained. The mean hydrodynamic size of nanoparticles according to photon correlation spectroscopy was 200 nm and zeta potential was -57 mV. Cytotoxic activity of agaricinic acid nanoparticles against human HepG2 hepatoma cells was evaluated. Nanoparticles with a low concentration of agaricinic acid stimulated and with high concentration - suppressed metabolic activity and viability of hepatoma cells. The EC
50 for the stimulating effect was 32.8 μg/ml, and the IC50 =602.1 mg/ml. The preparation of agaricinic acid nanoparticles can be used in medicine as a potential antitumor agent.- Published
- 2020
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