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1. PD-L1 and CD58 co-regulated by CMTM6 play yin and yang to shape anti-tumor immunity.

Author

Yamaguchi, Hirohito and Hung, Mien-Chie

Subjects
*PROGRAMMED death-ligand 1, *CELLULAR immunity, *IMMUNITY, *CANCER cells, *T cells
Abstract

The CD58-CD2 axis regulates T cell-mediated cancer immunity, but little is known about the regulation of CD58. In two recent papers pubished in Cancer Cell , Miao et al. and Ho et al. define a mechanism of CD58 regulation by CMTM6 and show an unexpected yin-yang link between PD-L1 and CD58. The CD58-CD2 axis regulates T cell-mediated cancer immunity, but little is known about the regulation of CD58. In two recent papers published in Cancer Cell , Miao et al. and Ho et al. define a mechanism of CD58 regulation by CMTM6 and show an unexpected yin-yang link between PD-L1 and CD58. [ABSTRACT FROM AUTHOR]

Published
2023
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