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Start Over Author "Shojaeian, Ali" Journal cancer investigation
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1. Inhibitory Effects of Bilirubin on Colonization and Migration of A431 and SK-MEL-3 Skin Cancer Cells Compared with Human Dermal Fibroblasts (HDF).

Author

Saffari-Chaleshtori, Javad, Shojaeian, Ali, Heidarian, Esfandiar, and Shafiee, Sayed Mohammad

Subjects
*HOST-bacteria relationships, *STATISTICS, *FIBROBLASTS, *ANALYSIS of variance, *MICRORNA, *SKIN tumors, *CELL motility, *GENE expression, *DESCRIPTIVE statistics, *CELL lines, *DATA analysis software, *DATA analysis, *POLYMERASE chain reaction, *BIOLOGICAL assay, *MOLECULAR structure, *BILIRUBIN, *CHEMICAL inhibitors
Abstract

This study evaluated the inhibitory effects of bilirubin on colony formation and cell migration of melanoma and non-melanoma skin cancer cell lines SK-MEL-3 and A431, compared with normal human dermal fibroblasts (HDF). The IC50 obtained from the MTT assay was 125, 100, and 75 μM bilirubin for HDF, A431, and SK-MEL-3 cells, respectively. The colony formation and cell migration of cancer cells, treated with 100 μM bilirubin, were reduced significantly (p < 0.05). Bilirubin decreased cell adhesion and inhibited cell colonization via inducing apoptosis and cell death. Also by interaction with migration main factors, bilirubin caused inhibition the cell migration. [ABSTRACT FROM AUTHOR]

Published
2021
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