Search

Your search keyword '"Kulkarni, Sarang"' showing total 3 results
Start Over Author "Kulkarni, Sarang" Journal cell
3 results on '"Kulkarni, Sarang"'

1. A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells

Author

Wells, Clark D., Fawcett, James P., Traweger, Andreas, Elder, Kelly; Colwill, Karen, Kulkarni, Sarang, Starostine, Andrei, Yamanaka, Yojiro, Virag, Cristina; Pawson, Tony, and Goudreault, Marilyn; Lim, Caesar

Subjects
Epithelial cells -- Research, Genetic research, Biological sciences
Abstract

A network of protein interactions that centre around the Cdc42 RhoGAP Rich1 and organize apical polarity in MDCK epithelial cells is identified. Rich1 and Amot maintain tight junctions (TJ) integrity by the coordinate regulation of Cdc42 and by linking specific components of the TJ to intracellular protein trafficking.

Published
2006

2. UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans

Author

Steven, Robert, Kubiseski, Terrance J., Zheng Hong, Kulkarni, Sarang, Mancillas, Jorge, Morales, Alberto Ruiz, Hogue, Chris W.V., Pawson, Tony, and Culotti, Joe

Subjects
Caenorhabditis elegans -- Genetic aspects, Cell physiology -- Research, Peptides -- Research, Biological sciences
Abstract

Research was conducted to characterize the unc-73 gene product from Caenorhabditis elegans as it relates to guided cell and growth cone migrations. Results showed that unc-73 affected several cell migrations in C. elegans and influenced pioneer and non-pioneer growth cone and cell migrations. They also indicated that the unc-73 peptide was capable of activating Rac and inducing actin reorganization characteristic of membrane ruffling.

Published
1998

Catalog

Books, media, physical & digital resources
See catalog results