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Your search keyword '"Shahida Shujaat"' showing total 2 results
Start Over Author "Shahida Shujaat" Journal chemical and pharmaceutical bulletin
2 results on '"Shahida Shujaat"'

1. BETA.-N-Cyanoethyl Acyl Hydrazide Derivatives: A New Class of .BETA.-Glucuronidase Inhibitors

Author

Khalid Mohammed Khan, Atta-ur-Rahman, Safdar Hayat, Shagufta Rahat, Shahida Shujaat, and Muhammad Iqbal Choudhary

Subjects
chemistry.chemical_classification, biology, Nitrile, Stereochemistry, Chemistry, General Chemistry, General Medicine, Hydrazide, Chemical synthesis, humanities, Glucuronidase, chemistry.chemical_compound, Hydrazines, Non-competitive inhibition, Enzyme, Enzyme inhibitor, Drug Discovery, biology.protein, Animals, Cattle, Uncompetitive inhibitor, Glycoproteins
Abstract

Eight new beta-N-substituted acyl hydrazides along with their corresponding acyl derivatives were synthesized and screened for in vitro beta-glucuronidase inhibition and found to be active against the enzyme. All of these compounds were found to be noncompetitive inhibitors except for N'-(2-cyanoethyl)-4-hydroxy benzohydrazide (10), which was found to be an uncompetitive inhibitor. Structure-activity relationship studies indicated that the benzyloxy group present in compounds 12 and 13 is responsible for the beta-glucuronidase inhibition activity.

Published
2002
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2. A Novel .BETA.-Glucuronidase Inhibiting Triterpenoid from Paeonia emodi

Author

Hafiz Rub Nawaz, Shahida Shujaat, Pir Muhammad Khan, Abdul Malik, and Atta-ur Rahman

Subjects
Asia, Spectrophotometry, Infrared, Stereochemistry, Ethyl gallate, Spectrometry, Mass, Fast Atom Bombardment, Methylation, Paeonia emodi, chemistry.chemical_compound, Triterpenoid, Triterpene, Betulinic acid, Drug Discovery, Enzyme Inhibitors, Oleanolic acid, Glucuronidase, chemistry.chemical_classification, Plants, Medicinal, Chloroform, biology, Chemistry, Acetylation, General Chemistry, General Medicine, biology.organism_classification, Triterpenes
Abstract

A novel beta-glucuronidase inhibiting triterpene (1) has been isolated from the chloroform fraction of Paeonia emodi beta-glucuronidase inhibit established ase chloroform fraction of Pa 11,beta,5alpha,23,24-pentahydroxy-30-norolean-12,20(29)-d ien-28-oic acid on the basis of spectroscopic analysis, including high resolution mass spectroscopy, one and two-dimensional NMR techniques. Oleanolic acid, betulinic acid, ethyl gallate, methyl grevillate and 1,5-dihydroxy-3-methylanthraquinone are also reported for the first time from Paeonia emodi.

Published
2000
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