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1. A chiral trimethyl lock based on the vicinal disubstituent effect: prolonged release of camptothecin into cancer cells.

Author

Venturi, Silvia, Chiaradonna, Ferdinando, Gatti, Francesco G., La Ferla, Barbara, Palorini, Roberta, and Zerbato, Barbara

Subjects
*CAMPTOTHECIN, *CANCER cells, *HYDROLASES, *TUMOR microenvironment, *PANCREATIC cancer, *ANTINEOPLASTIC agents
Abstract

Synthesis and in vitro testing of a prodrug designed for the controlled delivery of the anticancer drug camptothecin within pancreatic cancer cells are reported. Our study reveals a non-conventional pharmacokinetic release characterized by an exponential pattern before reaching the half-life (t1/2) and a linear pattern thereafter. The release mechanism was triggered either by hydrolytic enzymes and/or by the acid microenvironment of cancer cells. [ABSTRACT FROM AUTHOR]

Published
2024
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