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Racemic 2-carbethoxy-2-cyclopenten-1-ol [(±)- 3a ] and racemic 2-carbethoxy-2-cyclohexen-1-ol [(±)- 3b ] afforded the corresponding ( R -acetates [( R )- 4a and ( R )- 4b ] leaving the corresponding ( S )-alcohols [( S )- 3a and ( S )- 3b ] unchanged upon treatment with vinyl acetate in tert -butyl methyl ether in the presence of lipase PS, respectively, while the racemic acetates [(±)- 4a and (±)- 4b ], derived from racemic precursors, (±)- 3a and (±)- 3b , on suspension with lipase in a phosphate buffer solution afforded the corresponding ( R )-alcohols [( R )- 3a and ( R )- 3b ] leaving the corresponding ( S )-acetates [( S )- 4a and ( S )- 4b ] unchanged, respectively.

A series of new tetracyclic indenothiazoles is designed and synthesized with the aid of structure-based drug design (14 examples).