1. Hydroxylamine‐Mediated C(sp2)−H Trifluoromethylation of Terminal Alkenes.
- Author
-
Zhao, Xiao, Zhong, Bing, Dong, Likun, Zhang, Yu‐Shan, Luo, Hai‐Tian, Yang, Jin‐Dong, and Cheng, Jin‐Pei
- Subjects
ALKENES ,RADICALS (Chemistry) ,FUNCTIONAL groups ,ORGANIC compounds - Abstract
Introduction of the trifluoromethyl (CF3) group into organic compounds has garnered substantial interest because of its significant role in pharmaceuticals and agrochemicals. Here, we report a hydroxylamine‐mediated radical process for C(sp2)−H trifluoromethylation of terminal alkenes. The reaction shows good reactivity, impressive E/Z selectivity (up to >20 : 1), and broad functional group compatibility. Expansion of this approach to perfluoroalkylation and late‐stage trifluoromethylation of bioactive molecules demonstrates its promising application potential. Mechanistic studies suggest that the reaction follows a radical addition and subsequent elimination pathway. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF