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Sarglanoids A–F, six new sesquiterpenoids belonging to eudesmane ( 1 – 5 ) and eremophilane ( 6 ) types, were isolated from the leaves of Sarcandra glabra, a famous traditional Chinese medicine (TCM). Their structures including absolute configurations were elucidated through extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Thereinto, compounds 1 – 2 were rare N-containing eudesmane-type sesquiterpenoids. Compound 3 exhibited inhibitory activity against nitric oxide (NO) production in lipopolysaccharides (LPS)-induced RAW 264.7 cells with IC50 values at 20.00 ± 1.30 μM. This research provides scientific basis for sesquiterpenoids as the medicinal material foundation of S. glabra.