Search

BACKGROUND: Exosomes have become one of the frontiers of biomedical research in recent years because of their promising applications in clinical diagnosis and therapy. OBJECTIVE: To reveal the basic research and technology development trend of exosomes at home and abroad, and provide suggestions for related scientific and technological research and development in China. METHODS: This paper presented a quantitative analysis of the overall research and development situation, the frontier hotspots and future development trends in this research area by means of bibliometric methods and tools. RESULTS AND CONCLUSION: The research and development hotspots in this area have entered a high growth phase with the application of new tools and methods. Many new technologies and products are facing clinical applications and markets with the development of a large number of clinical translation experiments. Comparative analysis at home and abroad reveals that China has made more remarkable achievements in basic research in this field, but there are still weaknesses in the possession of independent intellectual property rights, clinical technology translation, and regulatory system standardization and management, which need to be further strengthened in the future. [ABSTRACT FROM AUTHOR]

BACKGROUND: Gastric cancer stem cells are a hot research topic in the medical field in recent years. Gastric cancer stem cells can interfere with the occurrence, metastasis, recurrence and drug resistance of gastric cancer. In theory, gastric cancer stem cells are the most promising candidate targets for the treatment of gastric cancer in the future. Therefore, studying the action mechanism of gastric cancer stem cells can not only elucidate the occurrence and development of gastric cancer, but also help to find new effective molecular targets, and has broad application prospects. OBJECTIVE: To summarize the hot spots and development trends of gastric cancer stem cells and to provide a reference for scientific researchers in related fields based on bibliometric and visualized analysis. METHODS: CiteSpace was employed to conduct the visualized analysis of annual publications, authors, countries, journals, citations and keywords of the related papers from 2011 to 2021 in the Web of Science Core Collection. RESULTS AND CONCLUSION: A total of 2 832 papers were included for analysis after screening. The annual publications increased rapidly, and the United States and China were the top contributors. Although the total number of papers published by Chinese researchers ranked the first in the world, the papers had low centrality and citation frequency, which indicated low quality and weak academic influence. Oncotarget was the journal with the largest number of articles published, and Oncology Letters was the journal with the largest number of articles published by Chinese researchers. Gastric cancer stem cells presented the trend of interdisciplinary development. The current studies about gastric cancer stem cells mainly focused on epithelial-mesenchymal transition; effect on biological function of gastric cancer cells and self-renewal. The plasticity of gastric cancer stem cells, the relationship with fatty acid oxidation and vascular endothelial growth factor, and the regulation of non-coding RNA on gastric cancer stem cells may be the focus of current and future research. The research of gastric cancer stem cells is currently in a rapid rise stage. In recent years, the action mechanism of gastric cancer stem cells is gradually clear. The treatment of gastric cancer stem cells will be a new targeted therapy strategy for gastric cancer patients in the future. [ABSTRACT FROM AUTHOR]

BACKGROUND: Femoroacetabular impingement syndrome is one of the main causes of hip pain, and there is a lack of research in the field of rehabilitation for femoroacetabular impingement syndrome in China. OBJECTIVE: To present the research trends and research hotspots in the field of femoroacetabular impingement syndrome rehabilitation based on the Web of Science and Citespace software in the form of scientific data combined with atlas and to analyze research prospects and propose future research directions. METHODS: Keywords regarding femoroacetabular impingement syndrome rehabilitation from 2012 to 2021 were searched in the Web of Science Core Collection, and the results were bibliometrically analyzed. Citespace software was then used to conduct visually analyze countries, institutions, authors, journals, keywords and co-cited references. Finally, research trends and hotspots in the past 10 years were summarized. RESULTS AND CONCLUSION: Femoroacetabular impingement syndrome rehabilitation has gradually attracted the attention of scholars and the number of publications and citations has increased yearly, with the United States taking the lead. Chinese scholars have published fewer papers in this field and only have cooperative relations with Australian and American scholars. China’s influence in this field needs to be improved. Keyword and literature co-citation burst analyses indicate that the research trends are gait function in patients with femoroacetabular impingement syndrome, clinical efficacy of non-surgical treatment/conservative treatment/physiotherapy for femoroacetabular impingement syndrome, and the efficacy of hip arthroscopy vs. non-surgical treatment. The high-frequency co-citations, high centrality and cluster analyses indicate that the research hotspots in this field are exploring the diagnosis of pain due to femoroacetabular impingement syndrome, the short-, medium-, and long-term clinical effects of non-surgical treatment vs. hip arthroscopy, the rehabilitation effect of physiotherapy, the applicability of self-report scales, the rehabilitation scheme of femoroacetabular impingement syndrome with cartilage injury or glenoid lip injury and paying attention to their rehabilitation process, preventing femoroacetabular impingement syndrome from progressing to osteoarthritis. Based on the analysis of relevant literature in the past 10 years, this review details the future research directions in this field, including explorations on the clinical efficacy of non-surgical/surgical treatment, the middle- and long-term efficacy of non-surgical treatment vs. surgical treatment, the concurrent loss of femoroacetabular impingement syndrome, and randomized controlled trials on the prognosis and rehabilitation of femoroacetabular impingement syndrome. [ABSTRACT FROM AUTHOR]

BACKGROUND: Mesenchymal stem cells have the characteristics of self-renewal and multi-directional differentiation, and have great potential and application prospects in the treatment of intervertebral disc diseases. OBJECTIVE: To analyze the literature of mesenchymal stem cells in the treatment of intervertebral disc degenerative diseases using bibliometric analysis, and to understand the research trends and hotspots in this field, and to provide basis and suggestions for its follow-up development. METHODS: With the theme of mesenchymal stem cell therapy for intervertebral disc degeneration, we searched the relevant literature included in the Web of Science database from 2000 to 2019, analyzed the annual number of paper published, and scientific research funding. Citespace5.5.R2 software was used to analyze the cooperation relationship of authors, countries and research institutions, the co-citation of journals or literatures. Finally, cluster analysis, burst analysis and time zone graph analysis were performed on keywords. RESULTS AND CONCLUSION: (1) A total of 648 papers were included, with journal articles as the main type of literature. (2) Most of the funding were sponsored by China and USA (more than 50%). (3) A total of 206 authors were included, out of whom 70 authors published more than 3 papers, and the principal researchers were Daisuke Sakai (Japan) focusing on mesenchymal stem cells transplantation for intervertebral disc degeneration, Judith A Hoyland (Great Britain) focusing on regulation of myeloid cell phenotype by mesenchymal stem cells, and Makarand V Risbud (US) focusing on induction of mesenchymal stem cell differentiation. (4) 125 countries and institutions were included: China and USA were the two main countries. (5) 154 journals were included, as SPINE was the journal with the most published articles. (6) The keyword analysis showed that the research in this field can be divided into three phases: phase 1 from 2005 to 2012, mainly investigating gene expression differences, chondrogenic differentiation of mesenchymal stem cells, and extracellular matrix changes in the intervertebral disc; phase 2 from 2012 to 2017, mainly investigating mesenchymal stem cell injection therapy and changes in the microenvironment of the intervertebral disc; phase 3 from 2017 to 2019, the main study is cell therapy and disc regeneration promoted by mesenchymal stem cells. (7) The probably research direction was to extract mesenchymal stem cells and induce their differentiation to nucleus pulposus, paracrine secretion of mesenchymal stem cells on the function of disc cells and mesenchymal stem cells combined with tissue engineering technology to promote intervertebral disc regeneration. [ABSTRACT FROM AUTHOR]

BACKGROUND: The treatment of stem cells in intervertebral disc degeneration has always been a research hotspot. It is possible to predict and analyze the research status and development trend of this field to a certain extent, applying bibliometric analysis software to perform co-occurrence and co-citation analysis of numerous literature data in this field. OBJECTIVE: To analyze research status and development trend of stem cells in the treatment of intervertebral disc degeneration by bibliometric visualization analysis. METHODS: The authors retrieved the literature on stem cells in the treatment of intervertebral disc degeneration from 1999 to 2020 through the core collection of Web of Science, and used bibliometrics methods to conduct statistical analysis on the literature data, combined with Citespace 5.6.R5 and VOSviewer 1.6.15 software to transform the visualization atlas, analyze the research status and development trend of stem cells in the treatment of intervertebral disc. RESULTS AND CONCLUSION: (1) A total of 613 articles were included. The number of publications of stem cells in intervertebral disc treatment research is increasing year by year. Among them, China and the United States rank first and second with 232 and 174 publications respectively. (2) The United States has a total citation frequency (5 522), h index (42), and betweenness centrality (0.75) ranks first, both higher than the second place in China (3 169, 28, 0.16). (3) The top ten cited references introduced the research on the treatment of intervertebral disc degeneration with microscopic mesenchymal stem cells from various aspects, and seven of them were related to nucleus pulposus like differentiation of bone marrow mesenchymal stem cells. Two papers are related to the best cell source and cell carrier generation in the treatment of intervertebral disc regeneration. One is related to the clinical trial study of the treatment of degenerative disc regeneration. (4) The timeline chart of reference co-citation shows that the most references are published in clusters of “Mesenchymal Stem Cells”, “Notochord Cells”, “End Plates”, and “Adipose derived Mesenchymal Stem Cells”. From a year of publication perspective, the clustering “notochord cells”, “notochord”, and “injection” published in the latest year. (5) Clustering keywords “intervertebral disc degeneration”, “migration”, “notochord cells”, “genipin” and “hydrogel” correspond exactly to the above. It was confirmed that the keywords suddenly appeared and found that present research hotspots are: mesenchymal stem cell nucleus pulposus-like differentiation, the best cell source in the treatment of intervertebral disc regeneration and the clinical effectiveness and biosafety of cell carrier construction and intervertebral disc regeneration treatment. (6) There are five new keywords from 2017 to 2019, namely “injection”, “intervertebral disc degeneration”, “inflammation”, “apoptosis”, and “puncture”, mainly focusing on cell apoptosis, inflammatory reaction, intervertebral disc regression, and cell transplantation methodology. (7) The above-mentioned global trend analysis suggests that as the amount of stem cells published in the treatment of intervertebral disc degeneration continues to increase, related research is also constantly deepening. The current research focuses on the nucleus pulposus-like differentiation of mesenchymal stem cells, the best cell source and cell carrier integration in the treatment of intervertebral disc regeneration, and the clinical effectiveness and biological safety of integration of intervertebral disc regeneration treatment. In-depth exploration of the mechanism of intervertebral disc degeneration and inflammatory response and improvement of cell transplantation methodology are the focus of future research. [ABSTRACT FROM AUTHOR]