1. The Dynamical Mechanisms of the Cell Cycle Size Checkpoint.
- Author
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FENG Shi-Fu, YAN Jie, LIU Zeng-Rong, and YANG Ling
- Subjects
CELL size ,CELL cycle ,MATHEMATICAL models ,CELL growth ,CELLULAR mechanics ,XENOPUS laevis ,BIFURCATION theory - Abstract
Cell division must be tightly coupled to cell growth in order to maintain cell size, whereas the mechanisms of how initialization of mitosis is regulated by cell size remain to be elucidated. We develop a mathematical model of the cell cycle, which incorporates cell growth to investigate the dynamical properties of the size checkpoint in embryos of Xenopus laevis. We show that the size checkpoint is naturally raised from a saddle-node bifurcation, and in a mutant case, the cell loses its size control ability due to the loss of this saddle-node point. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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