1. Type 2 diabetes mellitus is associated with faster degeneration of bioprosthetic valve: results from a propensity score-matched Italian multicenter study
- Author
-
Roberto, Lorusso, Sandro, Gelsomino, Fabiana, Lucà, Giuseppe, De Cicco, Giuseppe, Billè, Rocco, Carella, Emmanuel, Villa, Emanuel, Villa, Gianni, Troise, Mario, Viganò, Carlo, Banfi, Carmine, Gazzaruso, Pier, Gagliardotto, Lorenzo, Menicanti, Francesco, Formica, Giovanni, Paolini, Stefano, Benussi, Ottavio, Alfieri, Matteo, Pastore, Sandro, Ferrarese, Giovanni, Mariscalco, Germano, Di Credico, Cristian, Leva, Claudio, Russo, Aldo, Cannata, Roberto, Trevisan, Ugolino, Livi, Roberto, Scrofani, Carlo, Antona, Andrea, Sala, Gian Franco, Gensini, Jos, Maessen, Andrea, Giustina, Lorusso, R, Gelsomino, S, Lucà, F, De Cicco, G, Billè, G, Carella, R, Villa, E, Troise, G, Viganò, M, Banfi, C, Gazzaruso, C, Gagliardotto, P, Menicanti, L, Formica, F, Paolini, G, Benussi, S, Alfieri, O, Pastore, M, Ferrarese, S, Mariscalco, G, Di Credico, G, Leva, C, Russo, C, Cannata, A, Trevisan, R, Livi, U, Scrofani, R, Antona, C, Sala, A, Gensini, G, Maessen, J, Giustina, A, Luca', F, Bille', G, Vigano', M, Alfieri, Ottavio, Gensini, Gf, Giustina, Andrea, RS: CARIM - R2.12 - Surgical intervention, CTC, and MUMC+: MA Cardiothoracale Chirurgie (3)
- Subjects
Male ,medicine.medical_specialty ,Glycated Hemoglobin A ,type 2 diabetes mellitus ,Heart Valve Diseases ,Diabetes, aortic valve replacement, bioprosthetic valve ,Type 2 diabetes ,Bioprosthesis Diabetes Mellitus Follow-Up Studies Hyperglycemia Prosthesis Failure Risk Factors ,Postoperative Complications ,Predictive Value of Tests ,Risk Factors ,Physiology (medical) ,Internal medicine ,Diabetes mellitus ,Diabetes Mellitus ,Medicine ,Humans ,Aged ,Bioprosthesis ,Diabetes Mellitus, Type 2 ,Female ,Follow-Up Studies ,Heart Valve Prosthesis ,Hyperglycemia ,Incidence ,Intensive Care Units ,Italy ,Multivariate Analysis ,Prosthesis Failure ,Glycated Hemoglobin ,business.industry ,Mortality rate ,Incidence (epidemiology) ,Type 2 Diabetes Mellitus ,medicine.disease ,Confidence interval ,Surgery ,MED/23 - CHIRURGIA CARDIACA ,Predictive value of tests ,heart valve surgery ,Propensity score matching ,Cardiology and Cardiovascular Medicine ,business ,prosthetic heart valves ,Type 2 - Abstract
Background— The present study was aimed at determining the impact of type 2 diabetes mellitus (DM) on postoperative bioprosthetic structural valve degeneration. Methods and Results— Twelve Italian centers participated in the study. Patient data refer to bioprosthetic implantations performed from November 1988 to December 2009, which resulted in 6184 patients (mean age 71.3±5.4 years, 60.1% male) being enrolled. Of these patients, 1731 (27.9%) had type 2 DM. The propensity score–matching algorithm successfully matched 1113 patients with type 2 DM with the same number of no-DM patients. The postmatching standard differences were less than 0.1 for each of the covariates, and 64.2% of DM patients were matched. The early (30 days) mortality rate was 7.8% (n=87) versus 2.9% (n=33) in patients with or without type 2 DM ( P P Conclusions— Patients with type 2 DM undergoing bioprosthetic valve implantation are at high risk of early and long-term mortality, as well as of structural valve degeneration.
- Published
- 2011