1. Functional regulatory roles of microRNAs in atherosclerosis.
- Author
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Gao, Ya, Peng, Juan, Ren, Zhong, He, Ni-ya, Li, Qing, Zhao, Xue-shan, Wang, Mei-mei, Wen, Hong-yan, Tang, Zhi-han, Jiang, Zhi-sheng, Wang, Gui-xue, and Liu, Lu-shan
- Subjects
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MICRORNA , *ATHEROSCLEROSIS treatment , *ENDOTHELIAL cells , *CELL proliferation , *VASCULAR smooth muscle , *THERAPEUTICS - Abstract
MicroRNAs are a group of endogenously small non-coding RNA molecules that downregulate gene expression at the post-transcriptional level through binding to the 3′UTR of target mRNAs. Recent findings have revealed a key role for microRNAs in the pathophysiological processes of atherosclerosis. As a complex disease, atherosclerosis is influenced by a combination of multiple genes and environmental factors. Both of them play a role in atherogenesis by affecting different types of cells (such as endothelial cell, vascular smooth muscle cell and monocyte/macrophage) function. MicroRNAs control the senescence and dysfunction of endothelial cells, proliferation and migration of vascular smooth muscle cells, and macrophage-driven cytokine production and polarization. By these effects, microRNAs can influence the processes of atherosclerosis and may represent new molecular targets for therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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